Results 151 to 160 of about 8,866,660 (204)

Multilevel mortality risk factors among pediatric hematology‐oncology patients with deterioration

open access: yesCancer, Volume 131, Issue 8, 15 April 2025.
Abstract Background Hospitalized pediatric hematology‐oncology patients have frequent clinical deterioration events (CDEs) requiring intensive care unit (ICU) interventions and resulting in high mortality, particularly in resource‐limited settings. This study identifies independent risk factors for CDE mortality in hospitals providing childhood cancer ...
Asya Agulnik   +47 more
wiley   +1 more source

Multi‐omics profiling reveals key factors involved in Ewing sarcoma metastasis

open access: yesMolecular Oncology, Volume 19, Issue 4, Page 1002-1028, April 2025.
Using a mouse model that recapitulates the spread of tumor cells within the body, we have profiled paired tumors and metastasis samples using a multiomics approach combining different layers of biological information. We identified key genes that drive metastasis in Ewing sarcoma.
Mariona Chicón‐Bosch   +11 more
wiley   +1 more source

Body contour adaptation for weight‐loss and bolus for head and neck radiotherapy on Ethos version 2.0 and HyperSight: Synthetic CT versus direct calculation

open access: yesJournal of Applied Clinical Medical Physics, Volume 26, Issue 4, April 2025.
Abstract Purpose In radiotherapy, body contour inaccuracies may compromise the delineation of adjacent structures and affect calculated dose. Here, we evaluate the un‐editable body contours auto‐generated by Ethos versions 1.0 (v1) and 2.0 (v2) treatment planning softwares for two simulated cases: weight‐loss and bolus application, particularly ...
Abby Yashayaeva   +2 more
wiley   +1 more source

Optoelectronically Innervated Suction Cup Inspired by the Octopus

open access: yesAdvanced Intelligent Systems, Volume 7, Issue 4, April 2025.
This work presents an octopus‐inspired suction cup capable of high‐resolution estimation of the orientation of the suction cup with respect to an object surface. A camera captures the displacement of markers that are integrated in the suction cup using an automated design and manufacturing process.
Stein van Veggel   +5 more
wiley   +1 more source

FlexMol: A Flexible Toolkit for Benchmarking Molecular Relational Learning [PDF]

open access: yesarXiv
Molecular relational learning (MRL) is crucial for understanding the interaction behaviors between molecular pairs, a critical aspect of drug discovery and development. However, the large feasible model space of MRL poses significant challenges to benchmarking, and existing MRL frameworks face limitations in flexibility and scope.
arxiv  

Amyloid precursor protein and presenilin‐1 knock‐in immunodeficient mice exhibit intraneuronal Aβ pathology, microgliosis, and extensive neuronal loss

open access: yesAlzheimer's &Dementia, Volume 21, Issue 4, April 2025.
Abstract INTRODUCTION Transgenic mice overexpressing familial Alzheimer's disease (AD) mutations (FAD) show non‐physiological traits, and their immunocompetent backgrounds limit their use in AD immunotherapy research. Preclinical models that reflect human immune responses in AD are needed. METHODS Using CRISPR‐Cas9, we developed single (NA) and double (
Pravin Yeapuri   +13 more
wiley   +1 more source

3D Interaction Geometric Pre-training for Molecular Relational Learning [PDF]

open access: yesarXiv
Molecular Relational Learning (MRL) is a rapidly growing field that focuses on understanding the interaction dynamics between molecules, which is crucial for applications ranging from catalyst engineering to drug discovery. Despite recent progress, earlier MRL approaches are limited to using only the 2D topological structure of molecules, as obtaining ...
arxiv  

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