Results 81 to 90 of about 424,058 (165)

Immunosenescence and Vaccine Efficacy in Aging: Dynamic Interplay of Gut Microbiota and mTOR Signaling Pathways

Aging Cell, Volume 25, Issue 6, June 2026.
Aging impairs vaccine efficacy through gut microbiota dysbiosis and mTOR hyperactivation, which together drive inflammaging and weaken immune memory. This review highlights the bidirectional microbiota–mTOR axis and proposes that combining mTOR inhibitors with microbiota modulation offers a promising strategy to enhance vaccine responses in older ...
Jiaxuan Li, Yuhong Zhang, Daijun Yu, Jianhua Li, Keda Chen, Lisheng Chu   +5 more
wiley   +1 more source

mRNA or ChAd0x1 COVID-19 vaccination of adolescents induces robust antibody and cellular responses with continued recognition of omicron following mRNA-1273

, 2022
Children and adolescents generally experience mild COVID-19. However, those with underlying physical health conditions are at a significantly increased risk of severe disease.
E Linley (21491957), S Ahmad (5575955), M Lim (9947426), M Ayodele (21491936), J Gunn (7338521), A Collins (7952654), J Poh (13650478), S Scott (7202651), F Baawuah (21491948), F Davis (13471717), ME Ramsay (21491906), M White (9887555), C Davis (7706315), J Zuo (9851051), G Ireland (13670413), I Okike (21491945), AJ Brent (7657916), J Wright (7728401), J Cohen (7751054), N Logan (14557460), R Azad (19229983), P Moss (7787393), E Jinks (21491939), B Brent (21491954), SN Ladhani (21491891), E Spalkova (14579618), D Waiblinger (21491960), J Beckmann (13279284), P Sylla (14579612), SM Nicol (21491942), AA Powell (21491933), G Amirthalingam (16342536), BJ Willett (14557457), K Brown (7679720), AC Dowell (21491930), R Bruton (14579627), J Garstang (21491951), J Kenny (13514788)   +37 more
core  

Delayed skin reaction after mRNA-1273 vaccine against SARS-CoV-2: a rare clinical reaction

, 2021
BACKGROUND: The coronavirus disease 2019 (COVID-19) is associated with a wide clinical spectrum of skin manifestations, including urticarial, vesicular, vasculitic and chilblain-like lesions.
Rezazadeh, Amir, Albrecht G. Schmidt, Tom Luedde, Julia Reifenberger, Bölke, Edwin, Freise, Noemi F, Buhren, Bettina Alexandra, Stefan Salzmann, Martijn van Griensven, Meller, Stephan, Schneider, Marion, Torsten Feldt, Tamaskovics, Balint, Alessia Pedoto, Knoefel, Wolfram Trudo, Hoff, Norman-Philipp, Maas, Kitti, Schmidt, Albrecht G, Jensen, Björn Erik Ole, Homey, Bernhard, Schmidt, Livia, Fischer, Johannes C, Peter Arne Gerber, Pedoto, Alessia, Braun, Stephan A, Reifenberger, Julia, Wolfram Trudo Knoefel, Feldt, Torsten, Salzmann, Stefan, Braun, Stephan A., Matuschek, Christiane, Edwin Bölke, Livia Schmidt, Balint Tamaskovics, Firouzi-Memarpuri, Parnian, Grebe, Olaf, Kitti Maas, Verena Keitel, Johannes C. Fischer, Schmidt, Albrecht G., Boelke, Edwin, Noemi F. Freise, Budach, Wilfried, Fischer, Johannes C., van Griensven, Martijn; id_orcid, Christiane Matuschek, Haussmann, Jan, Häussinger, Dieter, Norman-Philipp Hoff, Freise, Noemi F., Björn Erik Ole Jensen, Marion Schneider, Stephan Meller, van Griensven, Martijn, Dieter Häussinger, Gerber, Peter Arne, Olaf Grebe, Jan Haussmann, Keitel, Verena, Wilfried Budach, Stephan A. Braun, Luedde, Tom, Parnian Firouzi-Memarpuri, Bernhard Homey, Amir Rezazadeh, Bettina Alexandra Buhren   +65 more
core   +1 more source

mRNA Lipid Nanoparticles for Cell Engineering in Vivo and in Vitro: Current Applications and Future Directions

MedComm, Volume 7, Issue 5, May 2026.
Schematic diagram of mRNA‐lipid nanoparticles (mRNA‐LNP) and its functional mechanisms, applications, and challenges in cell engineering. This figure details the structural composition of mRNA‐LNPs and the delivery strategy, highlighting three core challenges.
Lina Li, Menglan Wang, Xiuhan Ye, Zhiyan Liu, Yijing Duan, Xiaoming Chen, Yue Ouyang, Qibiao Wu, Mengjuan Sun, Tian Xie   +9 more
wiley   +1 more source

SARS‐CoV‐2 Variants and Immune Evasion: Mapping the Future of Vaccine Design

Reviews in Medical Virology, Volume 36, Issue 3, May 2026.
ABSTRACT The evolutionary trajectory of Severe Acute Respiratory Syndrome Coronavirus 2 (SARS‐CoV‐2) has progressed through several distinct phases since its zoonotic emergence, transitioning from initial human adaptation to an era of rapid antigenic drift and complex immune evasion. As of early 2026, the global landscape is dominated by highly evolved
Fatih Uzer, Fulya Erendor, Salih Sanlioglu   +2 more
wiley   +1 more source

DataSheet_1_Profiling antibody epitopes induced by mRNA-1273 vaccination and boosters.pdf

BackgroundCharacterizing the antibody epitope profiles of messenger RNA (mRNA)-based vaccines against SARS-CoV-2 can aid in elucidating the mechanisms underlying the antibody-mediated immune responses elicited by these vaccines.MethodsThis study ...
Michael Jhatro (18175222), John Shon (11306175), Spyros Chalkias (4789221), Darin K. Edwards (18175228), Thomas W. Campbell (18175210), Jack Coupart (18175213), Brian Martinez (8766183), Elisabeth Baum-Jones (14320527), Rebecca L. Best (18175207), Minlu Zhang (148373), Bethany Girard (18175204), Abhilash Dhal (18175219), Robert Paris (190952), Rolando Pajon (166045), Kyla Dangerfield (18175216), Jack Reifert (18175225), Maha Maglinao (2171449), Rebecca Waitz (11414165)   +17 more
core   +1 more source

Polymer library for mRNA delivery

, 2022
1
KIM, WON JONG
core  

Extrahepatic Gene Editing In Vivo Using Organic Solvent‐Free Lipid Nanoparticles

Small, Volume 22, Issue 27, 14 May 2026.
This article highlights a novel, organic solvent‐free lipid nanoparticle (LNP) formulation that avoids cholesterol, thereby reducing hepatic accumulation and immune activation. These BLNPs enable potent, flexible, and scalable gene delivery, supporting personalized medicine and diverse nucleic acid applications.
Michael Streiber, Na Liu, Laurianne Simon, Franziska Adermann, Vivien Bachmann, Lucas Gath, Stephanie Hoeppener, Stephanie Schubert, Oliver Werz, Vincent Lapinte, Marie Morille, Michael Bauer, Adrian T. Press, Ulrich S. Schubert, Anja Traeger   +14 more
wiley   +1 more source

Myocarditis after BNT162b2 and mRNA-1273 COVID-19 vaccination: A report of 7 cases

, 2022
This is a multi-center case series study. In this study, we present 7 patients diagnosed with myocarditis following BNT162b2 and mRNA-1273 COVID-19 vaccination on March 7, 2021, and March 3 ...
Sirwan Khalid Ahmed
core   +1 more source

Investigating Low‐Temperature Stress Responses in Crustacea Aquatic Species Through Comparative Transcriptomics

Evolutionary Applications, Volume 19, Issue 5, May 2026.
ABSTRACT Crustaceans, such as shrimp and crabs, are pivotal to global aquaculture, yet their productivity is severely impacted by low‐temperature stress. This study employs comparative transcriptomic and genomic analyses to elucidate the molecular mechanisms underlying crustacean responses to cold stress across five economically significant species ...
Ying Chen, Weihua Yan, Tong Xu, Shengyu Xu, Qifan Zeng, Zhe Qu, Zhenmin Bao, Hao Wang   +7 more
wiley   +1 more source