Results 91 to 100 of about 29,486 (214)

Engineering Lipid Nanoparticles for Precision RNA Delivery: Design Principles, Targeting Strategies, and Clinical Prospects

Cancer Nexus, Volume 2, Issue 2, April 2026.
ABSTRACT Lipid nanoparticles (LNPs) represent the most clinically advanced platform for RNA delivery and have enabled major breakthroughs in vaccines and gene therapies. However, their broader application is still limited by inefficient extrahepatic delivery, immunogenicity, and insufficient control over tissue‐ and cell‐specific targeting. This review
Yu Han, Ying Wang, Xintao Gao, Yan Lei, Yantao Li, Zhiyong Tang   +5 more
wiley   +1 more source

A review of the immunogenicity and safety of booster doses of omicron variant-containing mRNA-1273 COVID-19 vaccines in adults and children

Expert Review of Vaccines
Introduction Vaccination against SARS-CoV-2 is an integral pillar of the public health approach to COVID-19. With the emergence of variants of concern that increase transmissibility and escape from vaccine- or infection-induced protection, vaccines have ...
Frances Priddy, Spyros Chalkias, Brandon Essink, Jordan Whatley, Adam Brosz, Ivan T. Lee, Jing Feng, LaRee Tracy, Weiping Deng, Wen Zhou, Honghong Zhou, Avika Dixit, Sabine Schnyder Ghamloush, Bethany Girard, Elizabeth de Windt, Anne Yeakey, Jacqueline Miller, Rituparna Das, Barbara J. Kuter   +18 more
doaj   +1 more source

From Immunization to Autoimmunity: A Deep Dive Into Post‐COVID‐19 Vaccine Reactions—A Narrative Review

Health Science Reports, Volume 9, Issue 4, April 2026.
ABSTRACT Background and Aims Coronavirus disease‐2019 (COVID‐19) emerged in 2019 from Wuhan, China, leading to the accelerated development of vaccines, which have proven instrumental in controlling the spread of the virus. While vaccination ceased the increasing trend of the viral infection, rare adverse autoimmune events emerged as important ...
Mohammad Javad Yousefi‐Hashemabad, Saeed Hashemi, Kiarash Saleki, Seyed Mohamad Kazem Nourbakhsh, Andia Saleki, Zahra Hassanzadeh, Abbas Azadmehr   +6 more
wiley   +1 more source

Time and cost of administering COVID-19 mRNA vaccines in the United States

Human Vaccines & Immunotherapeutics, 2021
In early 2020, the World Health Organization (WHO) declared the coronavirus disease 2019 (COVID-19) outbreak a global pandemic. In response, two novel messenger RNA (mRNA)-based vaccines: mRNA-1273 (Moderna) and BNT162b2 (Pfizer-BioNTech) were rapidly ...
Benjamin Yarnoff, Steven Bodhaine, Ed Cohen, Philip O. Buck   +3 more
doaj   +1 more source

Premixed Lidocaine With Fospropofol Disodium for Safety and Clinical Evaluation Regarding Paresthesia Upon Fospropofol Disodium Injection: A Preclinical Experimental Study and a Randomized Controlled Trial

MedComm, Volume 7, Issue 4, April 2026.
This study explored the effect of lidocaine premixing on fospropofol‐induced paresthesia. While the mixture of fospropofol (FP) and lidocaine (LD) proved chemically stable and safe in preclinical tests, clinical results from randomized controlled trial showed no reduction in paresthesia in FP+LD group compared with FP+NS group.
Bo Jiao, Xiaolin Xu, Ying Cui, Caiyi Yan, Liyun Deng, Dequan Zhong, Qing Yang, Jiqian Xu, Yi Liu, Xiaohui Sun, Mengqian Xu, Tao Liu, Hui Xu, Xuejiao Tang, Xiaoqin Luo, Peng Liang, Jin Liu, Chan Chen   +17 more
wiley   +1 more source

Comparative mRNA booster effectiveness against death or hospitalization with COVID-19 pneumonia across at-risk US Veteran populations

Nature Communications, 2023
Studies of comparative mRNA booster effectiveness among high-risk populations can inform mRNA booster-specific guidelines. The study emulated a target trial of COVID-19 vaccinated U.S.
J. Daniel Kelly, Samuel Leonard, W. John Boscardin, Katherine J. Hoggatt, Emily N. Lum, Charles C. Austin, Amy Byers, Phyllis C. Tien, Peter C. Austin, Dawn M. Bravata, Salomeh Keyhani   +10 more
doaj   +1 more source

Factors Associated With Self‐Medication to Mitigate Vaccine Reactions After COVID‐19 Vaccination: A Prospective Cohort Study

Pharmacoepidemiology and Drug Safety, Volume 35, Issue 4, April 2026.
ABSTRACT Objective Management of vaccine reactions with analgesics/antipyretics can enhance acceptance and adherence to future vaccinations. However, inappropriate self‐medication may pose health risks, particularly for individuals with chronic conditions.
Maximilian Blattner, Ingmar Schäfer, Yvonne Nestoriuc, Christian Büchel, Martin Scherer, Jan Hendrik Oltrogge‐Abiry   +5 more
wiley   +1 more source

Moderna (mRNA-1273) Covid-19 Vaccine, “A Systematic Review” [PDF]

, 2021
A Global pandemic, declared by WHO, caused due to a deadly virus known as a “SARS-Cov-2”, has resulted in 4.3 million deaths. Its RNA based genome and lack of proofreading ability has made this virus more prone to get the frequent mutations and results ...
Abid, Sidra, Imam, Meisha, Rehan, Hafiz Muhammad, Zahid, Rohama   +3 more
core   +1 more source

Bone Morphogenetic Protein (BMP) 9 Outperforms BMP2 in Osteogenesis and Osseointegration: In Vitro and In Vivo

Clinical Implant Dentistry and Related Research, Volume 28, Issue 2, April 2026.
ABSTRACT Objectives This study compared the osteogenic mechanisms and preclinical efficacy of bone morphogenetic protein 9 (BMP9) and BMP2 in vitro and in a beagle peri‐implant defect model in vivo. Materials and Methods In vitro, MC3T3‐E1 preosteoblasts were treated with BMP2 or BMP9 to assess osteogenic gene expression (Col1, Runx2, Alp, Ocn) by real‐
Hee‐seung Han, Dong Woo Lee, Yu‐Bin Kim, Sanghui Seok, Jeong Yeon Park, Sungtae Kim, Jue Yeon Lee, Yoon Jeong Park, Chong Pyung Chung, Young‐Dan Cho   +9 more
wiley   +1 more source

mRNA-1273 vaccination protects against SARS-CoV-2 elicited lung inflammation in non-human primates [PDF]

, 2021
Adam T. Waickman, Kaitlin Victor, Krista L. Newell, Tao Li, Heather Friberg, Kathy Foulds, Mario Roederer, Diane L. Bolton, Jeffrey R. Currier, Robert A. Seder   +9 more
openalex   +1 more source