Results 121 to 130 of about 3,391,200 (390)

Highways for mRNA Transport [PDF]

Cell, 2008
Two new studies reveal the role of microtubule polarity in the asymmetric localization of mRNAs. In this issue of Cell, Zimyanin et al. (2008) show that the asymmetric localization of oskar mRNA in fruit fly oocytes results from a slight bias in the direction of its transport. Meanwhile, Messitt et al.
openaire   +3 more sources

Peripheral blood proteome biomarkers distinguish immunosuppressive features of cancer progression

Molecular Oncology, EarlyView.
Immune status significantly influences cancer progression. This study used plasma proteomics to analyze benign 67NR and malignant 4T1 breast tumor models at early and late tumor stages. Immune‐related proteins–osteopontin (Spp1), lactotransferrin (Ltf), calreticulin (Calr) and peroxiredoxin 2 (Prdx2)–were associated with systemic myeloid‐derived ...
Yeon Ji Park, Jae Won Oh, Hyewon Chung, Jung Won Kwon, Yi Rang Na, Kwang Pyo Kim, Seung Hyeok Seok   +6 more
wiley   +1 more source

Evading innate immunity in nonviral mRNA delivery : don't shoot the messenger [PDF]

, 2016
In de field of non-viral gene therapy, in vitro transcribed (IVT) mRNA has emerged as a promising tool for the delivery of genetic information. Over the past few years it has become widely known the introduction of IVT mRNA into mammalian cells elicits ...
Akira, Akira, Akira, Alexopoulou, Allen, Anderson, Anderson, Andries, Angel, Auphan, Awe, Baba, Balachandran, Ballas, Banchereau, Bhattacharyya, Bonehill, Borden, Carroll, Chauhan, Clark, Coller, Conry, Courreges, Dewitte, Dewitte, Diebold, Diebold, Diken, Drews, El-Sayed, Fotin-Mleczek, Gallie, Garcia, George, Goubau, Grudzien-Nogalska, Gupta, Hacker, Halpern, Harii, Hartner, He, Heil, Heleen Dewitte, Heufler, Hoerr, Hornung, Hu, Ikeda, Ingrand, Israel, Jammi, Jha, Jha, Jirikowski, Joke Devoldere, Kallen, Kambara, Kanneganti, Kariko, Kariko, Kariko, Kariko, Kariko, Kariko, Katrien Remaut, Kawai, Kettle, Komuro, Kormann, Koski, Kreiter, Krieg, Krieg, Kumar, Kumar, Kuznik, Lee, Leonhardt, Li, Liniger, Loiarro, Lonez, Lorenz, Mandal, Mantovani, Martin, Martinon, Mays, Myskiw, Nallagatla, Nallagatla, Nekhai, Okumura, Pardi, Pascolo, Pascolo, Pathak, Pfaller, Pichlmair, Pichlmair, Pichlmair, Plews, Pollard, Qiu, Quintas-Cardama, Quintas-Cardama, Rajsbaum, Rejman, Rettig, Rothenfusser, Rowland, Sabbah, Sadler, Sahin, Samuel, Satoh, Scheel, Scheinman, Schlee, Schmidt, Schmolke, Schwartz, Sen, Silverman, Smith, Stefaan C. De Smedt, Sugiyama, Takahashi, Tang, Tavernier, Tavernier, Toshchakov, Tros de Ilarduya, Van Lint, Wang, Wang, Warren, Warren, Wells, Wolff, Xiang, Yakubov, Yamamoto, Yang, Yoneyama, Yoneyama, Yoshioka, Zangi, Zhu, Zhu, Zust   +152 more
core   +1 more source

Ionizable Lipid Nanoparticle Mediated mRNA Delivery for Human CAR T Cell Engineering.

Nano letters (Print), 2020
CAR T cell therapy relies on the ex vivo manipulation of patient T cells to create a potent, cancer-targeting therapy, shown to be capable of inducing remission in patients with acute lymphoblastic leukemia and large B cell lymphoma. However, current CAR
Margaret M. Billingsley, Nathan Singh, Pranali Ravikumar, Rui Zhang, C. June, M. J. Mitchell   +5 more
semanticscholar   +1 more source

Transcriptome‐wide analysis of circRNA and RBP profiles and their molecular relevance for GBM

Molecular Oncology, EarlyView.
CircRNAs are differentially expressed in glioblastoma primary tumors and might serve as therapeutic targets and diagnostic markers. The investigation of circRNA and RNA‐binding proteins (RBPs) interactions shows that distinct RBPs play a role in circRNA biogenesis and function.
Julia Latowska‐Łysiak, Żaneta Zarębska, Marcin P. Sajek, Adriana Grabowska, Alessia Buratin, Paweł Głodowicz, Julia O. Misiorek, Konrad Kuczyński, Stefania Bortoluzzi, Marek Żywicki, Jan G. Kosiński, Agnieszka Rybak‐Wolf, Rafał Piestrzeniewicz, Anna M. Barciszewska, Katarzyna Rolle   +14 more
wiley   +1 more source

Versican splice variant messenger RNA expression in normal human Achilles tendon and tendinopathies [PDF]

, 2004
Versican is the principal large proteoglycan expressed in mid-tendon, but its role in tendon pathology is unknown. Our objective was to define the expression of versican isoform splice variant messenger ribonucleic acid (mRNA) in normal Achilles tendons,
Corps, AN, Costa, ML, Hazleman, BL, Ireland, DC, Movin, T, Riley, GP, Robinson, AHN   +6 more
core   +2 more sources

Ontogenic Profile of Gluconeogenic Key Enzyme Gene Expressions in Embryonic Chicken Liver and Muscle

The Journal of Poultry Science, 2013
To elucidate biochemical mechanisms underlining high plasma glucose in chicken embryo, gene expression profile of gluconeogenic key enzymes were characterized.
Tushar K. Roy, Atsushi Iwasawa, Yasutake Shimizu, Koji Kageyama, Norio Yoshizaki   +4 more
doaj   +1 more source

Differential expression and methylation of integrin subunit alpha 11 and thrombospondin in the amnion of preterm birth [PDF]

Obstetrics & Gynecology Science, 2018
ObjectiveThis study aimed to investigate the association between preterm birth and epigenetic mechanisms in the amnion.MethodsWe examined the association between differentially methylated regions (DMRs) and differentially expressed genes (DEG) using a ...
Jae Young Yoo, Young-Ah You, Eun Jin Kwon, Mi Hye Park, Sunah Shim, Young Ju Kim   +5 more
doaj   +1 more source

The promise of mRNA vaccines: a biotech and industrial perspective

npj Vaccines, 2020
mRNA technologies have the potential to transform areas of medicine, including the prophylaxis of infectious diseases. The advantages for vaccines range from the acceleration of immunogen discovery to rapid response and multiple disease target ...
Nicholas A. C. Jackson, K. Kester, D. Casimiro, S. Gurunathan, F. Derosa   +4 more
semanticscholar   +1 more source

Degradation of mRNA in eukaryotes

Cell, 1995
Based on the above mechanisms of mRNA degradation, an integrated model of mRNA turnover can be proposed (Figure 1). In this model, all polyadenylated mRNAs would be degraded by the deadenylation-dependent pathway at some rate. In addition to this default pathway, another layer of complexity would come from degradation mechanisms specific to individual ...
Roy Parker, Roy Parker, Clare A. Beelman
openaire   +3 more sources