Results 151 to 160 of about 3,421,970 (401)

Chemoresistome mapping in individual breast cancer patients unravels diversity in dynamic transcriptional adaptation

Molecular Oncology, EarlyView.
This study used longitudinal transcriptomics and gene‐pattern classification to uncover patient‐specific mechanisms of chemotherapy resistance in breast cancer. Findings reveal preexisting drug‐tolerant states in primary tumors and diverse gene rewiring patterns across patients, converging on a few dysregulated functional modules. Despite receiving the
Maya Dadiani, Gilgi Friedlander, Gili Perry, Nora Balint‐Lahat, Shlomit Gilad, Dana Morzaev‐Sulzbach, Anjana Shenoy, Noa Bossel Ben‐Moshe, Anya Pavlovsky, Rinat Bernstein‐Molho, Eytan Domany, Iris Barshack, Tamar Geiger, Bella Kaufman, Einav Nili Gal‐Yam   +14 more
wiley   +1 more source

Tonic signaling of the B‐cell antigen‐specific receptor is a common functional hallmark in chronic lymphocytic leukemia cell phosphoproteomes at early disease stages

Molecular Oncology, EarlyView.
B‐cell chronic lymphocytic leukemia (B‐CLL) and monoclonal B‐cell lymphocytosis (MBL) show altered proteomes and phosphoproteomes, analyzed using mass spectrometry, protein microarrays, and western blotting. Identifying 2970 proteins and 316 phosphoproteins, including 55 novel phosphopeptides, we reveal BCR and NF‐kβ/STAT3 signaling in disease ...
Paula Díez, Pablo Juanes‐Velasco, Marina L. García‐Vaquero, Conrad Droste, Alicia Landeira‐Viñuela, Miguel Alcoceba, Helena Fidalgo‐Gómez, Sara Misiego‐Herrero, Almudena Navarro‐Bailón, Mónica Baile, José M. Bastida, Jose Manuel Sanchez‐Santos, Rafael Góngora, Julia Almeida, Marcos Gonzalez‐Diaz, Alberto Orfao, Javier De Las Rivas, Manuel Fuentes   +17 more
wiley   +1 more source

CRYPTOBACTERIUM CURTUM: A NOVEL BACTERIA WITH A POSSIBLE SIGNIFICANT INVOLVEMENT IN PERIODONTAL DISEASE. A REVIEW.

Romanian Journal of Oral Rehabilitation, 2023
Periodontal disease is considered to be connected with some very well-known anaerobic etiological agents. Many studies are analysing the associations between Porphyromonas gingivalis, Aggregatibacter actinomycetemcomitans and Tannerella forsythia with ...
Oana Bejan, Giorgio Nichitean, Oana Butnaru, Monica Tatarciuc, Maria-Alexandra Martu, Gabriel Rotundu, Iris-Malina Maftei, Costin Damian, Ramona Ursu, Ionuț Luchian   +9 more
doaj  

Synopsis: Special Issue on “Disruption of signaling homeostasis induced crosstalk in the carcinogenesis paradigm Epistemology of the origin of cancer”

4 open, 2019
It is increasingly evident that carcinogenesis, in the vast majority of cancers, cannot be explained simply through an accumulation of somatic mutations, or epigenetics, the stem cell theory, or the Warburg effect.
Brücher Björn L.D.M., Jamall Ijaz S.
doaj   +1 more source

mRNA vaccine-elicited antibodies to SARS-CoV-2 and circulating variants

Nature, 2021
Zijun Wang, F. Schmidt, Y. Weisblum, F. Muecksch, C. Barnes, Shlomo Finkin, Dennis J. Schaefer-Babajew, M. Cipolla, C. Gaebler, J. Lieberman, Thiago Y. Oliveira, Zhi Yang, M. Abernathy, Kathryn E Huey-Tubman, A. Hurley, Martina Turroja, K. West, Kristie M Gordon, Katrina G. Millard, Victor Ramos, Justin Da Silva, Jianliang Xu, R. Colbert, R. Patel, Juan P Dizon, Cecille Unson-O’Brien, I. Shimeliovich, A. Gazumyan, M. Caskey, P. Bjorkman, R. Casellas, T. Hatziioannou, P. Bieniasz, M. Nussenzweig   +33 more
semanticscholar   +1 more source

Expression and DNA methylation of 20S proteasome subunits as prognostic and resistance markers in cancer

Molecular Oncology, EarlyView.
Comprehensive analysis of genomic mutations, gene expression, DNA methylation, and pathway analysis of TCGA data was carried out to define cancer types in which proteasome subunits expression is associated with worse survival. Albeit the effect of specific proteasome subunits on cellular function, the main role of the proteasome is better evaluated ...
Ruba Al‐Abdulla, Simone Venz, Ruslan Al‐Ali, Martin Wendlandt, Mandy Radefeldt, Elke Krüger   +5 more
wiley   +1 more source

cis-acting sequences and trans-acting factors in the localization of mRNA for mitochondrial ribosomal proteins [PDF]

, 2008
mRNA localization is a conserved post-transcriptional process crucial for a variety of systems. Although several mechanisms have been identified, emerging evidence suggests that most transcripts reach the protein functional site by moving along ...
AMORESANO, ANGELA, C. Cirulli, PIETROPAOLO, CONCETTA, PUCCI, PIETRO, RUSSO, ANNAPINA, RUSSO, GIULIA   +5 more
core   +1 more source

mRNA-leksjon [PDF]

Tidsskrift for Den norske legeforening, 2021
openaire   +3 more sources

Early metastasis is characterized by Gr1+ cell dysregulation and is inhibited by immunomodulatory nanoparticles

Molecular Oncology, EarlyView.
Breast cancer metastasis is associated with myeloid cell dysregulation and the lung‐specific accumulation of tumor‐supportive Gr1+ cells. Gr1+ cells support metastasis, in part, through a CHI3L1‐mediated mechanism, which can be targeted and inhibited with cargo‐free, polymeric nanoparticles.
Jeffrey A. Ma, Sophia M. Orbach, Kate V. Griffin, Kathryn Kang, Yining Zhang, Rebecca S. Pereles, Ian A. Schrack, Guillermo Escalona, Jacqueline S. Jeruss, Lonnie D. Shea   +9 more
wiley   +1 more source

Integrated Bioinformatics Analysis for the Identification of Key lncRNAs, mRNAs, and Potential Drugs in Clear Cell Renal Cell Carcinomas

International Journal of General Medicine, 2023
Sheng Liu,1,* Guanyun Shi,1 Zhengbo Pan,1 Weisong Cheng,1 Linfei Xu,1 Xingzhang Lin,1 Yongfeng Lin,1 Liming Zhang,1 Guanghua Ji,1 Xin Lv,1 Dongguo Wang2,* 1Department of Urinary Surgery, Taizhou Municipal Hospital Affiliated with Taizhou ...
Liu S, Shi G, Pan Z, Cheng W, Xu L, Lin X, Lin Y, Zhang L, Ji G, Lv X, Wang D   +10 more
doaj