Importin 7 mediates the nuclear import of HIV‐1 integrase via a specific interacting interface
FEBS Open Bio, EarlyView.HIV‐1 integrase enables viral DNA integration into the host genome. By binding to the core domain of the host protein Importin 7 via its C‐terminal domain, the integrase is transported across the nuclear membrane into the nucleus, where integration of the viral genome into host DNA takes place. This translocation is a critical step for subsequent viral
Juana Bana +5 more
wiley +1 more source
32 Chapter 3 Selection of RNA-Binding Peptides
, 2014 We are interested in the discovery of novel RNA binding peptides using in vitro selection. To do this, we use mRNA-protein fusions, peptides covalently attached to their encoding mRNA. Here, we report selection protocols developed using the arginine-rich
Using Mrna-peptide Fusions
core
Malformin A1–mediated cytotoxicity in ovarian cancer cells occurs through pyroptosis and autophagy
FEBS Open Bio, EarlyView.This study investigated the effects of the natural compound Malformin A1 (MA1) on the cytoskeleton that regulates cell proliferation and migration. Disruption of the cytoskeleton can impair these processes and promote cancer cell death. MA1 disrupted cytoskeletal organization, induced DNA damage, inflammation, activated autophagy, and pyroptosis ...
Nada Abdullah Hassan +11 more
wiley +1 more source
IFN-γ-Mediated Innate Immunity in Females Is Less Efficient than That in Males in Restricting Cerebral Proliferation of <i>Toxoplasma</i> Tachyzoites During Reactivation of Chronic Infection with the Parasite. [PDF]
CellsMani R, Ochiai E, Sa Q, Suzuki Y.
europepmc +1 more source
Ionomycin suppresses cancer cell growth by disrupting mitochondrial transcription
FEBS Open Bio, EarlyView.In this study, we identify a new function for the selective Ca2+ ionophore, ionomycin, as an inhibitor of mitochondrial transcription. Both total and nascent RNA analyses revealed that ionomycin treatment reduces the transcription of mitochondrial genes.
Lishen Wang +10 more
wiley +1 more source
Ire1-Mediated Unfolded Protein Response and Other Biological Phenomena in <i>Ascomycota</i> Yeasts and Filamentous Fungi. [PDF]
CellsIkhrami MA, Kimata Y.
europepmc +1 more source
FEBS Open Bio, EarlyView.Lactoferrin promotes wound healing by activating MAPK, PI3K/Akt, and extracellular matrix pathways, enhancing fibroblast remodeling, proliferation, and re‐epithelialization. These mechanisms highlight its therapeutic potential in inflammation control, tissue repair, and remodeling.
Morgana Lüdtke Azevedo +4 more
wiley +1 more source
Trump and mRNA technologies: global health risks and opportunities in vaccine manufacturing diversification. [PDF]
Cad Saude PublicaMenezes HZ, Shadlen KC.
europepmc +1 more source
Evaluating the effect of γ‐oryzanol on MASLD pathology using a medaka fish model
FEBS Open Bio, EarlyView.This study explores a liver disease called MASLD, which is increasing worldwide and can lead to serious damage. Researchers used medaka fish instead of rodents to test a food compound, γ‐oryzanol. Fish fed this compound had less liver fat and healthier gut bacteria.
Yukako Ito +7 more
wiley +1 more source
Development of mRNA vaccines against herpes zoster. [PDF]
Hum Vaccin ImmunotherLi D +9 more
europepmc +1 more source