Results 191 to 200 of about 1,519,200 (263)

Remodelling of miRNA Regulatory Landscape During West Nile Virus (WNV) Infection. [PDF]

Epigenomes
De Hayr L, Khromykh AA, Slonchak A.
europepmc   +1 more source

Bacteria‐Responsive Nanostructured Drug Delivery Systems for Targeted Antimicrobial Therapy

Advanced Materials, EarlyView.
Bacteria‐responsive nanocarriers are designed to release antimicrobials only in the presence of infection‐specific cues. This selective activation ensures drug release precisely at the site of infection, avoiding premature or indiscriminate release, and enhancing efficacy.
Guillermo Landa, Gracia Mendoza, Silvia Irusta, Manuel Arruebo   +3 more
wiley   +1 more source

CD39 mRNA therapy attenuates localized acute inflammation: A novel anti-inflammatory strategy using cationic nanoliposomes. [PDF]

Mol Ther Nucleic Acids
Philosof NR, Walsh APG, Xu B, Watson AMD, Ren S, Hann L, Nathaniel B, Nguyen A, Liu H, Shi P, Bongcaron V, Nguyen H, Noonan J, Avci-Adali M, Peter K, Vidallon MLP, Wang X.   +16 more
europepmc   +1 more source

Lipid Nanoparticle Co‐Delivery of mRNA and a Small Molecule Drug for Oral Cancer Chemoimmunotherapy

Advanced Materials, EarlyView.
Co‐encapsulation of p53 mRNA and the small molecule ciclopirox within a lipid nanoparticle yields an all‐in‐one chemoimmunotherapy for oral squamous cell carcinoma. The platform engages caspase‐driven apoptosis in cancer cells while repolarizing tumor‐associated macrophages, achieving tumor reduction in both p53‐susceptible and p53‐resistant models and
Marshall S. Padilla, Jacqueline J. Li, Qunzhou Zhang, Korey Patwari, Shihong Shi, Hannah M. Yamagata, Ryann A. Joseph, Briyanna N. Hymms, Sridatta V. Teerdhala, Emily Fitzgerald, Ori Z. Chalom, Kushol Gupta, Mohamad‐Gabriel Alameh, Drew Weissman, Anh D. Le, Michael J. Mitchell   +15 more
wiley   +1 more source

Quantitative RNA pseudouridine landscape reveals dynamic modification patterns and evolutionary conservation across bacterial species. [PDF]

Elife
Xu L, Shen S, Zhang Y, Guo Z, Lu B, Huang J, Li R, Shen Y, Zhang LS, Deng X.   +9 more
europepmc   +1 more source

Mechanism‐Driven Nanoformulations for Cognitive Impairment Induced by Intermittent Hypoxia and Periodontitis

Advanced Materials, EarlyView.
Clinically, intermittent hypoxia (IH) is often accompanied by periodontitis, which accelerates cognitive impairment induced by IH. Novel Janus mesoporous gold‐silica nanoformulations (RVG‐Au&mSiO2‐TPP‐VB) enable intranasal delivery, achieve hierarchical targeting to neuronal mitochondria, effectively scavenge reactive oxygen species, inhibit the HIF‐1α/
Kai‐Run Zhang, Tianbao Zhu, An‐Qi Liu, Jia‐Jia Deng, Ya‐Li Han, Sheng‐Cai Qi, Xue Liu, Tian‐Yi Jiang, Ming‐Rui Zhai, Yu‐Ying He, Xiu‐Juan Li, Hong‐Ting Da, Rui Xu, Xiaomin Li, Jun Gao, Yue‐Hua Liu   +15 more
wiley   +1 more source

Post-transcriptional regulation of mRNA stability in pancreatic ductal adenocarcinoma. [PDF]

Front Immunol
Wang H, Liu P, Yamasaki J, Harada T, Sakaguchi T, Takimoto T, Saya H, Nagano O, Fukumura K.   +8 more
europepmc   +1 more source

An Ion‐Based Strategy Toward Synergistic Surface Functionalization Combining the Osteogenic Properties and NIR‐Mediated Antibacterial Activity of PEEK

Advanced Materials, EarlyView.
A multifunctional bioactive PEEK‐based implant (Mn@p/MBG‐SPEEK) is engineered to combat implant‐associated infections while promoting osteogenesis. The hybrid surface activates PI3K/Akt/mTOR and AP‐1 signaling pathways for osteogenic differentiation, while Mn coordination induces electronic coupling that narrows the HOMO‐LUMO energy gap and enhances ...
Zhiyan Xu, Ondřej Adam, Marek Doubrava, Ana M. Beltrán, Ivo Dlouhý, Xin Liu, Baiyan Sui, Aldo R. Boccaccini   +7 more
wiley   +1 more source

Spatiotemporal distribution of SARS-CoV-2 vaccines and vaccine-related proteins in mice and humans. [PDF]

Sci Rep
Heinrich F, Lücke J, Zhang S, Sabihi M, Bernreuther C, Giersch K, Allweiss L, Hartmann K, Thies E, Lange P, Matschke J, Kühl AA, Mothes R, Radbruch H, Schröder AS, Heinemann A, Dandri M, Aepfelbacher M, Huber S, Giannou A, Glatzel M, Ondruschka B, Lütgehetmann M, Krasemann S.   +23 more
europepmc   +1 more source