Results 161 to 170 of about 2,344,135 (339)

mRNA archaeology

, 2018
Different theories concerning the origin of mRNA point to the concatenation and expansion of proto- tRNA motifs or proto-tRNA-like structures bound to an amino-acid. We have used different biochemical and biophysical factors to search for motifs with a specific structure in the mRNA of the hepatitis C virus and other phylogenetically related ...
Gómez-Castilla, Jordi, Ariza-Mateos, Ascensión   +1 more
openaire   +1 more source

Comparing self‐reported race and genetic ancestry for identifying potential differentially methylated sites in endometrial cancer: insights from African ancestry proportions using machine learning models

Molecular Oncology, EarlyView.
Integrating ancestry, differential methylation analysis, and machine learning, we identified robust epigenetic signature genes (ESGs) and Core‐ESGs in Black and White women with endometrial cancer. Core‐ESGs (namely APOBEC1 and PLEKHG5) methylation levels were significantly associated with survival, with tumors from high African ancestry (THA) showing ...
Huma Asif, J. Julie Kim
wiley   +1 more source

Development of RT-qPCR assay for assessing the expression of ACTB and SDHA housekeeping genes in the cell cultures of mammalian hosts of zoonotic infections

Acta Biomedica Scientifica
Background. The molecular mechanisms behind the maintenance of zoonotic pathogens in nature can be better understood by examining the gene expression in host cells in response to the infection.
N. A. Liapunova, M. A. Khasnatinov, G. A. Danchinova, I. S. Solovarov   +3 more
doaj   +1 more source

Structural gene identification and mapping by DNA-mRNA hybrid-arrested cell-free translation. [PDF]

, 1977
Brett M. Paterson, Bryan E. Roberts, Edward L. Kuff   +2 more
openalex   +1 more source

Multidimensional OMICs reveal ARID1A orchestrated control of DNA damage, splicing, and cell cycle in normal‐like and malignant urothelial cells

Molecular Oncology, EarlyView.
Loss of the frequently mutated chromatin remodeler ARID1A, a subunit of the SWI/SNF cBAF complex, results in less open chromatin, alternative splicing, and the failure to stop cells from progressing through the cell cycle after DNA damage in bladder (cancer) cells. Created in BioRender. Epigenetic regulators, such as the SWI/SNF complex, with important
Rebecca M. Schlösser, Florian Krumbach, Eyleen Corrales, Geoffroy Andrieux, Christian Preisinger, Franziska Liss, Alexandra Golzmann, Melanie Boerries, Kerstin Becker, Ruth Knüchel, Stefan Garczyk, Bernhard Lüscher   +11 more
wiley   +1 more source

Features of influenza virus hemagglutinin genes and their recoding possibilities

Инфекция и иммунитет
The world has already entered the stage of increasing odds for a new pandemic, which prompts to seek out for new flu vaccines, because existing vaccines demonstrate only suboptimal effectiveness.
Eugene P. Kharchenko
doaj   +1 more source

Escape from TGF‐β‐induced senescence promotes aggressive hallmarks in epithelial hepatocellular carcinoma cells

Molecular Oncology, EarlyView.
Chronic TGF‐β exposure drives epithelial HCC cells from a senescent state to a TGF‐β resistant mesenchymal phenotype. This transition is characterized by the loss of Smad3‐mediated signaling, escape from senescence, enhanced invasiveness and metastatic potential, and upregulation of key resistance modulators such as MARK1 and GRM8, ultimately promoting
Minenur Kalyoncu, Dilara Demirci, Sude Eris, Bengisu Dayanc, Ece Cakiroglu, Merve Basol, Merve Uysal, Gulcin Cakan‐Akdogan, Fang Liu, Mehmet Ozturk, Gökhan Karakülah, Serif Senturk   +11 more
wiley   +1 more source

The intervening sequence of a mouse beta-globin gene is transcribed within the 15S beta-globin mRNA precursor. [PDF]

, 1978
S M Tilghman, Peter J. Curtis, David C. Tiemeier, Philip Leder, Charles Weissmann   +4 more
openalex   +1 more source

ShcD adaptor protein drives invasion of triple negative breast cancer cells by aberrant activation of EGFR signaling

Molecular Oncology, EarlyView.
We identified adaptor protein ShcD as upregulated in triple‐negative breast cancer and found its expression to be correlated with reduced patient survival and increased invasion in cell models. Using a proteomic screen, we identified novel ShcD binding partners involved in EGFR signaling pathways.
Hayley R. Lau, Hayley S. Smith, Begüm Alural, Claire E. Martin, Laura A. New, Manali Tilak, Sara L. Banerjee, Hannah N. Robeson, Nicolas Bisson, Anne‐Claude Gingras, Jasmin Lalonde, Nina Jones   +11 more
wiley   +1 more source

Sequence analysis of 5′[³²P labeled mRNA and tRNA using polyacrylamide gel electrophoresis [PDF]

, 1978
Raymond E. Lockard, Birgit Alzner-Deweerd, Joyce E. Heckman, Joseph MacGee, M. Wilson Tabor, Uttam L. RajBhandary   +5 more
openalex   +1 more source