Results 221 to 230 of about 2,706,783 (351)

Multi‐omics and low‐input proteomics profiling reveals dynamic regulation driving pluripotency initiation in early mouse embryos

FEBS Open Bio, EarlyView.
Mouse pre‐implantation development involves a transition from totipotency to pluripotency. Integrating transcriptomics, epigenetic profiling, low‐input proteomics and functional assays, we show that eight‐cell embryos retain residual totipotency features, whereas cytoskeletal remodeling regulated by the ubiquitin‐proteasome system drives progression ...
Wanqiong Li, Xi Xiao, Lingbin Qi, Chanyi Li, Sirui Song, Jiaying Qin, Zhigang Xue, Jinfeng Xue, Huaifang Li   +8 more
wiley   +1 more source

A symphony of immunity: How HPV mRNA-LNP vaccination orchestrates systemic anti-tumor responses. [PDF]

Mol Ther Nucleic Acids
Elia U, Peer D.
europepmc   +1 more source

Comprehensive analysis of mRNA–microRNA–lncRNA expression profiles in post-traumatic elbow heterotopic ossification using RNA sequencing and experimental validation

Limin Wang, Fanxiao Liu, Lianxin Li, Nan Liu, Jinlei Dong   +4 more
openalex   +1 more source

565. CCR5-Uco-TALEN – A Novel Transcription Activator-Like Effector Nuclease That Mediates High-Efficiency Knockout of HIV Co-Receptor CCR5 in Primary T Cells After mRNA Transfection [PDF]

, 2015
Ulrike Mock, Rafał Machowicz, Ilona Hauber, Stefan Horn, Pierre Abramowski, Belinda Berdien, Joachim Hauber, Boris Fehse   +7 more
openalex   +1 more source

Dihydroorotate dehydrogenase (DHODH) regulates trophoblast syncytialization through organelle stress–induced cellular senescence

FEBS Open Bio, EarlyView.
The inhibition of mitochondrial dihydroorotate dehydrogenase (DHODH) impairs syncytialization and induces cellular senescence via mitochondrial and endoplasmic reticulum stress in human trophoblast stem cells, elevating sFlt1/PlGF levels, a hallmark of placental dysfunction in hypertensive disorders of pregnancy.
Kanoko Yoshida, Kazuya Kusama, Ayaka Horiuchi, Yu Kawaguchi, Atsuya Tsuru, Mikihiro Yoshie, Kazuhiro Tamura   +6 more
wiley   +1 more source

Pattern of Detections Across Multiple Environmental Messenger RNAs (e-mRNAs) in Stressor-Exposed Zebrafish (<i>Danio rerio</i>). [PDF]

Ecol Evol
Lindsay DL, Mylroie JE, Gust KA, Cowan EM, Lance RF.   +4 more
europepmc   +1 more source

The Response Regulator SprE (RssB) Modulates Polyadenylation and mRNA Stability inEscherichia coli

, 2009
Valerie J. Carabetta, Bijoy K. Mohanty, Sidney R. Kushner, Thomas J. Silhavy   +3 more
openalex   +1 more source

Meta‐analysis fails to show any correlation between protein abundance and ubiquitination changes

FEBS Open Bio, EarlyView.
We analyzed over 50 published proteomics datasets to explore the relationship between protein levels and ubiquitination changes across multiple experimental conditions and biological systems. Although ubiquitination is often associated with protein degradation, our analysis shows that changes in ubiquitination do not globally correlate with changes in ...
Nerea Osinalde, Unai Alduntzin, Gorka Prieto, Ugo Mayor   +3 more
wiley   +1 more source

A lipid nanoparticle encapsulated CPA-CTD mRNA vaccine provides protection against <i>Clostridium perfringens</i>-driven diseases. [PDF]

Front Immunol
Jia Q, Xiang H, Le T, Wang J, Chang J, Wang F, Sun C, Tai W, Jiang Z, Yin X.   +9 more
europepmc   +1 more source

Erythropoietin modulates hepatic inflammation, glucose homeostasis, and soluble epoxide hydrolase and epoxides in high‐fat diet‐induced obese mice

FEBS Open Bio, EarlyView.
Erythropoietin administration suppresses hepatic soluble epoxide hydrolase (sEH) expression, leading to increased CYP‐derived epoxides. This is associated with a shift in hepatic macrophage polarization characterized by reduced M1 markers and increased M2 markers, along with reduced hepatic inflammation, suppressed hepatic lipogenesis, and attenuated ...
Takeshi Goda, Satoru Sugimoto, Chiharu Cho, Madoka Konishi, Nozomi Inoue, Satoshi Miyagaki, Yasuhiro Kawabe, Takuro Okamura, Masahide Hamaguchi, Hisakazu Nakajima, Michiaki Fukui, Masakazu Shinohara, Tomoko Iehara   +12 more
wiley   +1 more source