Results 131 to 140 of about 87,391 (262)

Nonsense-mediated mRNA decay inhibition reshapes the cancer immunopeptidome. [PDF]

Immunity
Vendramin R, Fu H, Fernandez Patel S, Zhao Y, Qian D, Ligammari L, Bartok O, Greenberg P, Levy R, Castro A, Thakkar K, Murai J, Lu WT, Sng CCT, Weller C, Beattie G, Bhamra A, Farriol-Duran R, Karagianni D, Augustine M, Dijkstra KK, Pinder CL, Simpson BS, Cheung GW, TRACERx Consortium, Galvez-Cancino F, Vlckova P, Surinova S, Rodriguez-Justo M, Shah M, McGranahan N, Carlton JG, Grönroos E, Reading JL, Samuels Y, Swanton C, Quezada SA, Litchfield K.   +37 more
europepmc   +1 more source

NIR‐II‐Trackable LYTACs Phyto‐Nanotheranostics for Source‐Microenvironment Dual‐Track ROS Regulation in Acute Gouty Arthritis

Advanced Science, EarlyView.
The TPR‐LYTACs nanomaterial offers a dual‐pathway strategy for precise gouty arthritis treatment by targeting and degrading the ROS‐producing enzyme NOX2 inside macrophages while its antioxidant core clears accumulated ROS outside. This “source inhibition and microenvironment scavenging” approach, guided by NIR‐II imaging, effectively controls local ...
Jian Zhang, Yingying Wang, Lujie Yu, Chunmei Jiang, Haoyu Liu, Yaohua Chen, Shutong Wu, Qin Liu, Lingling Wei, Xiaochun Zheng, Huifang Hao, Mengting Gao, Weiwei Kang, Rong Dai, Ziliang Zheng, Ruiping Zhang   +15 more
wiley   +1 more source

Nonsense-mediated mRNA decay safeguards telomeres in pluripotent stem cells. [PDF]

Nat Cell Biol
Markiewicz-Potoczny M, Lee SY, Chatterjee S, Mabin JW, Zinsser A, Sandhu R, Tricola G, Hogg JR, Lazzerini Denchi E.   +8 more
europepmc   +1 more source

Leonurine Ameliorates Doxorubicin‐Induced Cardiotoxicity via STING/NF‐κB/NLRP3 Inflammasome Signaling Pathway

Advanced Science, EarlyView.
ABSTRACT Doxorubicin‐induced cardiomyopathy (DIC) remains a dose‐limiting clinical challenge. This study reveals that cardiac vascular endothelial cells (CVECs) act as initial sensors of doxorubicin cardiotoxicity: circulating doxorubicin activates the cGAS‑STING pathway in CVECs, triggering NLRP3 inflammasome‑mediated pyroptosis and release of ...
Wang Jun, Chen Xiaoyang, Xu Jianglin, Yang Zhi, Tao Meijiao, He Jiale, Zhao Jiangfeng, Hei Xuanding, Xu Xuegong, Wang Wei, Li Chun   +10 more
wiley   +1 more source

5PSeq Explorer: interactive analysis of co-translational mRNA decay and ribosome dynamics. [PDF]

RNA Biol
Stevens I, Pelechano V.
europepmc   +1 more source

CCT2 Promotes Prostate Cancer Progression Through EIF3F‐Dependent Stabilization of FASN

Advanced Science, EarlyView.
ABSTRACT Prostate cancer (PCa) is increasingly recognized to be driven by dysregulated lipid metabolism. Although fatty acid synthase (FASN) is highly expressed in PCa, the mechanisms governing FASN protein stability and its functional integration into oncogenic lipid metabolism remain poorly defined.
Shun Xu, Yifan Zhang, Haolin Li, Shengyu Zhao, Xiaoran Dai, Qili Xu, Mintian Fei, Chun Li, Zhihui Zou, Baojun Wang, Li Zhang, Hui Wang, Ligang Zhang, Chaozhao Liang   +13 more
wiley   +1 more source

DDX24 modulates angiogenesis by promoting CCR4-NOT complex-dependent mRNA decay. [PDF]

Nucleic Acids Res
He S, Li B, Chen F, Huang J, Dong Y, Liu S, Liu C, Zhang Q, Wang L, Shan H, Gong Y, Yang J, He H.   +12 more
europepmc   +1 more source

Regulation of mRNA Decay [PDF]

Molecular Cell, 2004
openaire   +1 more source

Stem Cell Differentiation Disperses Transcriptional Clusters via a Conserved Surface‐Condensate Trajectory

Advanced Science, EarlyView.
Stem cell differentiation follows a conserved surface condensate trajectory: H3K27ac super enhancers nucleate large RNA polymerase II clusters that grow and unfold before transcriptional activity disperses them. This work reveals how biophysical forces at enhancer surfaces dynamically build and dismantle stem cell transcription hubs, reshaping cell ...
Tim Klingberg, Irina Wachter, Agnieszka Pancholi, Matthias Akyel, Yomna Gohar, Priya Kumar, Ana Miguel Fernandes, Yuzhi Bao, Alica Schmidt‐Heydt, Marcel Piepers, Alicia Günthel, Marcel Sobucki, Elisa Kämmer, Süheyla Eroğlu‐Kayıkçı, Stephan Allgeier, Sylvia Erhardt, Vasily Zaburdaev, Carmelo Ferrai, Lennart Hilbert   +18 more
wiley   +1 more source

Alternative splicing-triggered mRNA decay informs splice-switching targets for neurodevelopmental disorders. [PDF]

J Clin Invest
Hu K, Yang R, Qiu J, Feng X, LaPre KJ, Tanouye J, Yang Y, Zhang X.   +7 more
europepmc   +1 more source