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FHIT mRNA expression in thymoma
European Journal of Surgical Oncology (EJSO), 2003The FHIT gene is located at 3p14.2 a region frequently lost in multiple tumour types. Loss of FHIT expression has been found to occur frequently in multiple tumour types. We wished to investigate that FHIT mRNA levels in a series of thymomas.Expression of FHIT messenger ribonucleic acid (RNA) was evaluated by reverse transcription-polymerase chain ...
H, Sasaki +5 more
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TNF-α mRNA Expression Correlates with TGF-β mRNA Expression In Vivo
Inflammation, 2010TNF-α is postulated to play a significant role in regulating TGF-β(1) expression. In lung fibroblasts, for example, TNF-α is supposed to induce TGF-β(1) via AP-1 activation. TNF-α receptor, knock-out mice are resistant to induced fibrosis and over-expression of TNF-α causes increased TGF-β(1) production in mice. Therefore, we investigated whether TNF-α
Simone, Helmig +3 more
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Endothelial Cell Expression of Testican mRNA
Endothelium, 1997By screening random cDNAs from a continuous vascular endothelial cell line, EA.hy926, we identified a 5 kb mRNA that is expressed at high levels by this human cell line and by an early passage umbilical vein endothelial cell line. It is detected at lower levels in certain stromal cell lines, but it is not detected in most other cell lines tested ...
H S, Marr, M A, Basalamah, C J, Edgell
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Developmental expression of cannabinoid receptor mRNA
Developmental Brain Research, 1993Cloning of the cannabinoid receptor affords the opportunity to examine its developmental expression. Other G-protein-coupled receptor systems, those for the opioids for example, exhibit distinct ontogenies. For the initial study, therefore, cannabinoid receptor mRNA expression was assessed in rat pups postnatal days 3, 5, 8, 10, 12, 15, 18 and 21.
C R, McLaughlin, M E, Abood
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Unsupervised clustering in mRNA expression profiles
Computers in Biology and Medicine, 2006The development of microarray technologies gives scientists the ability to examine, discover and monitor the mRNA transcript levels of thousands of genes in a single experiment. Nonetheless, the tremendous amount of data that can be obtained from microarray studies presents a challenge for data analysis.
D K, Tasoulis +2 more
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Patterns of cerebral cortex mRNA expression
Journal of Neuroscience Research, 1990AbstractA pool of 163 clones, isolated by screening 60,000 members of a Macaca fascicularis cerebral cortex cDNA library with a cortex‐minus‐cerebellum subtracted probe prepared by the phenol enhancement method, was analyzed by Northern blot hybridization studies.
J, Bernal +4 more
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Multiple Sclerosis Journal, 2008
Background Interferon (IFN)-β therapy in multiple sclerosis (MS) has been suggested to promote a deviation from T lymphocyte production of pathogenic Th1 cytokines to less detrimental Th2 cytokines, but this is still controversial. We studied patterns of in vivo blood mononuclear cell (MNC) and whole blood cytokine and transcription factor mRNA ...
Krakauer, M. +4 more
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Background Interferon (IFN)-β therapy in multiple sclerosis (MS) has been suggested to promote a deviation from T lymphocyte production of pathogenic Th1 cytokines to less detrimental Th2 cytokines, but this is still controversial. We studied patterns of in vivo blood mononuclear cell (MNC) and whole blood cytokine and transcription factor mRNA ...
Krakauer, M. +4 more
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Reelin mRNA Expression During Mouse Brain Development
European Journal of Neuroscience, 1997AbstractUsing in situ hybridization, expression of the mRNA for reelin, the gene most probably responsible for the reeler trait, was studied during mouse brain development. from embryonic day 13 to maturity. The highest level of expression was found in Cajal‐Retzius neurons, while a high signal was also seen in the olfactory bulb, the external granular
Schiffmann, Serge N. +2 more
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Pharmaceutical strategies for optimized mRNA expression
BiomaterialsMessenger RNA (mRNA)-based immunotherapies and protein in situ production therapies hold great promise for addressing theoretically all the diseases characterized by aberrant protein levels. The safe, stable, and precise delivery of mRNA to target cells via appropriate pharmaceutical strategies is a prerequisite for its optimal efficacy. In this review,
Yingying Shi +5 more
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Canadian Journal of Physiology and Pharmacology, 2005
Chunghyuldan (CHD), a combinatorial drug that has antihyperlipidemic and anti-inflammatory activities, has been shown to improve arterial stiffness and inhibit stroke recurrence in clinical study. To understand the molecular basis of CHD's clinical effects, we explored its effect on cell proliferation and expression of nitric oxide synthase (NOS) and ...
Seong-Uk, Park +7 more
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Chunghyuldan (CHD), a combinatorial drug that has antihyperlipidemic and anti-inflammatory activities, has been shown to improve arterial stiffness and inhibit stroke recurrence in clinical study. To understand the molecular basis of CHD's clinical effects, we explored its effect on cell proliferation and expression of nitric oxide synthase (NOS) and ...
Seong-Uk, Park +7 more
openaire +2 more sources