Results 181 to 190 of about 664,318 (297)

Intestinal mRNA expression profile and bioinformatics analysis in a methamphetamine-induced mouse model of inflammatory bowel disease. [PDF]

Ann Transl Med, 2020
Sun J, Chen F, Chen C, Zhang Z, Zhang Z, Tian W, Yu J, Wang K.   +7 more
europepmc   +1 more source

Large‐scale bidirectional arrayed genetic screens identify OXR1 and EMC4 as modifiers of αSynuclein aggregation

FEBS Open Bio, EarlyView.
Activation of the mitochondrial protein OXR1 increases pSyn129 αSynuclein aggregation by lowering ATP levels and altering mitochondrial membrane potential, particularly in response to MSA‐derived fibrils. In contrast, ablation of the ER protein EMC4 enhances autophagic flux and lysosomal clearance, broadly reducing α‐synuclein aggregates.
Sandesh Neupane, Lea Nikolić, Lorenzo Maraio, Thomas Goiran, Nathan Karpilovsky, Stefano Sellitto, Vangelis Bouris, Jiang‐An Yin, Ronald Melki, Edward A Fon, Adriano Aguzzi, Elena De Cecco   +11 more
wiley   +1 more source

The relationship of methylation and mRNA expression profile of AUTS2 with suicidal ideation in adolescents with bipolar depression. [PDF]

BMC Psychiatry
Shen X, Wang C, Alimujiang A, Zhang C, Zou S, Liu L.   +5 more
europepmc   +1 more source

Intercompartmental communication in senescence

FEBS Open Bio, EarlyView.
Senescent cells experience structural changes in the plasma membrane, endoplasmic reticulum, mitochondria, lysosomes, nucleus, and cytoskeleton. These alterations disrupt crosstalk among cellular compartments, impairing vesicular trafficking, contact sites, and molecular flow.
Krystyna Mazan‐Mamczarz, Eleanor J. Wind, Jixiang Leng, Myriam Gorospe   +3 more
wiley   +1 more source

Valproic acid exposure alters histone deacetylase mRNA expression profile in oral cancer and premalignant cell lines. [PDF]

Biomed Rep
Al-Khafaji ASK, Qaddoori YB, Alabdei HH, Wang LM.   +3 more
europepmc   +1 more source

Expression Profile of 1,000 mRNAs from Rat Retina

Expression Profile of 1,000 mRNAs from Rat Retina
application/pdf Journal Article Backgrounds & Aims : Diabetic retinopathy is a major cause of new-onset blindness among diabetic adults that is characterized by increased vascular permeability, tissue ischemia, and neovascularization. To clarify the molecular mechanism responsible in the pathogenesis, it is important to understand the entire ...
openaire  

Blood‐based proteomic profiling reveals context‐dependent changes in BCL2‐associated signaling during taxane therapy in breast cancer patients

FEBS Open Bio, EarlyView.
Chemotherapy side effects significantly impact cancer survivors' quality of life. Using protein levels in blood samples from breast cancer patients before and after 12 weeks of taxane treatment, we detected treatment‐dependent changes in calcium signaling and aging pathways associated with cancer recurrence.
Saira Munshani, Eiman Y. Ibrahim, Rozalyn L. Rodwin, Leah M. Ferrucci, Kim Blenman, Maryam Lustberg, Barbara E. Ehrlich   +6 more
wiley   +1 more source

Analysis of mRNA expression profile in the treatment of diabetic foot ulcer healing by tibial cortex transverse distraction. [PDF]

Sci Rep
Fan ZQ, Zeng Q, Yu BF.
europepmc   +1 more source

The Effects of Aronia melanocarpa Juice Consumption on the mRNA Expression Profile in Peripheral Blood Mononuclear Cells in Subjects at Cardiovascular Risk. [PDF]

Nutrients, 2020
Stojković L, Jovanović I, Zivković M, Zec M, Djurić T, Zivotić I, Kuveljić J, Kolaković A, Kolić I, Djordjević A, Glibetić M, Alavantić D, Stanković A.   +12 more
europepmc   +1 more source

YIPFα1A expression is regulated by multilayered molecular mechanisms

FEBS Open Bio, EarlyView.
YIPFα1A, a five‐pass Golgi protein, is regulated at multiple layers. (1) Rare‐codon enrichment drives translation‐coupled mRNA decay. (2) A proximal 3′‐UTR element stabilizes mRNA. (3) A distal 3′‐UTR element included by alternate poly(A) site usage represses translation, which can be overridden by the proximal 3′‐UTR element.
Tokio Takaji, Yurika Nakanishi, Nobuhiro Nakamura   +2 more
wiley   +1 more source