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mRNA secondary structure optimization using a correlated stem–loop prediction [PDF]
Nucleic Acids Research, 2013 Secondary structure of messenger RNA plays an important role in the bio-synthesis of proteins. Its negative impact on translation can reduce the yield of protein by slowing or blocking the initiation and movement of ribosomes along the mRNA, becoming a major factor in the regulation of gene expression.
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On the secondary structure in mRNA
Biosystems, 1977Abstract The sequence present in DNA phase transcripts have been investigated by Niyogi (1973) using a technique in which mRNA is enzymatically digested to yield different size classes that are resolved chromatographically into populations of equal chain lengths.
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Familial Alzheimer's mutation: mRNA secondary structure revisited
Neurobiology of Aging, 1992It has been suggested that the mutation at position 717 of the amyloid precursor protein (APP), found in several cases of familial Alzheimer's disease, affects the secondary structure of the corresponding messenger RNA and the rate of its translation (10).
J, Brosius, D, Konings
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Secondary structure of pre-mRNA in nuclear ribonucleoprotein particles
Molecular Biology Reports, 1975The secondary structure of pre-mRNA in the specific nuclear ribonucleoprotein particles was investigated. After ribonuclease treatment of nuclear particles the majority of double-stranded RNA sequences was conserved. The in vivo existence of hairpin-like RNA structures is discussed.
J, Molnár, J, Besson, O P, Samarina
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Control of Prokaryotic Translational Initiation by mRNA Secondary Structure
1990Publisher Summary This chapter describes the evidence that differences in the secondary structures of RNA are probably the main cause of this unpredictability. Although it has been known for many years that secondary structures of mRNA can interfere with translational initiation, it is quite surprising to find a simple, linear relationship between ...
M H, de Smit, J, van Duin
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Molecular Microbiology, 1994
SummaryRNA secondary structure is important in a wide variety of biological processes, but relatively little is known about the pathways and kinetics of RNA folding. When the IS 10 transposase (tnp) gene is transcribed from a promoter outside the element, little increase in tnp expression is observed.
C K, Ma +5 more
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SummaryRNA secondary structure is important in a wide variety of biological processes, but relatively little is known about the pathways and kinetics of RNA folding. When the IS 10 transposase (tnp) gene is transcribed from a promoter outside the element, little increase in tnp expression is observed.
C K, Ma +5 more
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Concurrent Neutral Evolution of mRNA Secondary Structures and Encoded Proteins
Journal of Molecular Evolution, 2000Messenger RNA sequences often have to preserve functional secondary structure elements in addition to coding for proteins. We present a statistical analysis of retroviral mRNA which supports the hypothesis that the natural genetic code is adapted to such complementary coding.
Konecny, Jaromir +4 more
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Elements of the secondary structure in the DNA, complementary to pigeon globin mRNA
Molecular Biology Reports, 1974Pigeon globin mRNA isolated from reticulocyte polysomes was copied by means of RNA-directed DNA-polymerase in the presence of actinomycin d. Hydroxyapatite chromatography with and without formaldehyde and hydrolysis with S1 nuclease were used for evaluation of the secondary structure elements in cDNA synthesized by reverse transcription.
K G, Gasaryan +4 more
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Role of pre-mRNA secondary structures in the regulation of alternative splicing
Molecular Biology, 2016Alternative splicing of pre-mRNA is one of the main mechanisms regulating gene expression that generates multiple transcripts from one gene. The review considers the specific role that intramolecular secondary structures arising through the interaction of distant complementary regions of introns play in regulating alternative splicing.
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Codon usage and secondary structure of mRNA.
Nucleic acids symposium series, 1991The specific codon usage pattern of the repetitive unit nucleotide sequence of silk fibroin mRNA suggests that selection has operated on the codon usage to optimize the secondary structure characteristic of the mRNA. The correlation between the stability map of local secondary structure of type I collagen mRNA and the codon usage pattern and the ...
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