Results 281 to 290 of about 797,089 (324)

Lipid Nanocarrier-Based mRNA Therapy: Challenges and Promise for Clinical Transformation.

Small
Due to the outbreak of novel coronavirus pneumonia, messenger RNA (mRNA) technology has attracted heated attention. A specific, safe, and efficient mRNA delivery system is needed.
Wenchao Li, Chen Wang, Yifei Zhang, Yuanyuan Lu   +3 more
semanticscholar   +1 more source

Emerging mRNA therapies for cardiac fibrosis

American Journal of Physiology-Cell Physiology
Cardiac fibrosis has few specific interventions available for effective treatment. mRNA encapsulated in lipid nanoparticles could provide a novel solution for treating cardiac fibrosis. This AJP perspective discusses what possible strategies could rely on this technology, from in vivo-produced CAR T cells that kill pathological fibroblasts to in vivo ...
Blake Jardin, Jonathan A. Epstein
openaire   +2 more sources

T Cell Responses to Individualized Neoantigen Therapy mRNA-4157 (V940) Alone or in Combination With Pembrolizumab in the Phase 1 KEYNOTE-603 Study.

Cancer Discovery
mRNA-4157 (V940) is an individualized neoantigen therapy (INT) targeting up to 34 patient-specific tumor neoantigens to induce T cell responses and potentiate anti-tumor activity.
Justin F. Gainor, Manish R. Patel, Jeffrey S. Weber, Martin Gutierrez, J. E. Bauman, Jeffrey M Clarke, R. Julian, Aaron J. Scott, Jessica L Geiger, K. Kirtane, C. Robert-Tissot, Brandon Coder, Moomal Tasneem, Jing Sun, Wei Zheng, Lauren Gerbereux, Andressa Laino, Filippos Porichis, J. Russella Pollard, Peijie Hou, Vasudha Sehgal, Xing Chen, M. Morrissey, Hikmat N. Daghestani, Igor Feldman, Lakshmi Srinivasan, Joshua P Frederick, Michelle Brown, Praveen Aanur, R. Meehan, Howard A Burris   +30 more
semanticscholar   +1 more source

Optimized inhaled LNP formulation for enhanced treatment of idiopathic pulmonary fibrosis via mRNA-mediated antibody therapy

Nature Communications
Lipid nanoparticle-assisted mRNA inhalation therapy necessitates addressing challenges such as resistance to shear force damage, mucus penetration, cellular internalization, rapid lysosomal escape, and target protein expression.
Xin Bai, Qijing Chen, Fengqiao Li, Yilong Teng, Maoping Tang, Jia Huang, Xiaoyang Xu, Xue-Qing Zhang   +7 more
semanticscholar   +1 more source

Photodynamic therapy on mRNA levels in bacteria

Lasers in Medical Science
Antimicrobial photodynamic therapy (aPDT) has shown efficacy in inactivating different bacterial species by photosensitizer-induced free radical production. Despite aPDT is considered unable to cause resistant strains, enzymatic pathways for detoxification of reactive oxygen species and transmembrane photosensitizer efflux systems could cause ...
Bruno Ricardo Barreto, Pires, Flavia, de Paoli, Andre Luiz, Mencalha, Adenilson, de Souza da Fonseca   +3 more
openaire   +2 more sources

Chimeric antigen receptor therapy meets mRNA technology

Trends in Biotechnology
Genetically engineered immune cells expressing chimeric antigen receptors (CARs) have emerged as a new game changer in cancer immunotherapy. The utility of CAR T cell therapy against hematological malignancies has been validated in clinical practice. Other CAR immune cells are currently under investigation to improve the potency of CAR therapy in solid
Jiacai Wu, Weigang Wu, Boping Zhou, Bin Li   +3 more
openaire   +2 more sources

Emerging mRNA Technology for Liver Disease Therapy

ACS Nano
Liver diseases have consistently posed substantial challenges to global health. It is crucial to find innovative methods to effectively prevent and treat these diseases. In recent times, there has been an increasing interest in the use of mRNA formulations that accumulate in liver tissue for the treatment of hepatic diseases.
Ji Wang, Yile Fang, Zhiqiang Luo, Jinglin Wang, Yuanjin Zhao   +4 more
openaire   +2 more sources

Endogenous mRNA Triggered DNA-Au Nanomachine for in Situ Imaging and Targeted Multimodal Synergistic Cancer Therapy.

Angewandte Chemie, 2020
Development of versatile nanotheranostic platforms that integrate both diagnostic and therapeutic functions have always been an intractable challenge in precise cancer treatment.
Shaulov A Yu, Yang Zhou, Yao Sun, Shaojun Wu, Tingting Xu, Yu-Chung Chang, Sai Bi, Liping Jiang, Jun‐Jie Zhu   +8 more
semanticscholar   +1 more source

Efficient Colorectal Cancer Gene Therapy with IL-15 mRNA Nano-formulation.

Molecular Pharmaceutics, 2020
Immunogene therapy has acted as a novel mothed for the treatment of colorectal cancer. The cytokine IL-15 has exhibited therapeutic anti-cancer potential through immune stimulation property.
Sibei Lei, Xueyan Zhang, Ke Men, Yan Gao, Xijing Yang, Sisi Wu, Xingmei Duan, Yuquan Wei, Rongsheng Tong   +8 more
semanticscholar   +1 more source

mRNA Vaccination and Personalized Cancer Therapy

2014
Nucleic acid vaccines link two prerequisites for success, namely, the delivery of molecularly defined antigens as vaccine targets of interest and an inherent adjuvant activity. As compared to DNA-based approaches, in vitro-transcribed messenger RNA (mRNA) is a safer drug format due to the adjustable, transient expression and lack of genomic integration.
S. Kreiter, M. Diken, U. Sahin
openaire   +1 more source