Results 51 to 60 of about 797,089 (324)

Combining p53 mRNA nanotherapy with immune checkpoint blockade reprograms the immune microenvironment for effective cancer therapy

Nature Communications, 2022
Immunotherapy with immune checkpoint blockade (ICB) has shown limited benefits in hepatocellular carcinoma (HCC) and other cancers, mediated in part by the immunosuppressive tumor microenvironment (TME).
Yuling Xiao, Jiang Chen, Hui Zhou, Xiaodong Zeng, Z. Ruan, Zhangya Pu, Xingya Jiang, A. Matsui, Lingling Zhu, Zohreh Amoozgar, Dean Shuailin Chen, Xiangfei Han, D. Duda, Jinjun Shi   +13 more
semanticscholar   +1 more source

Translation of Angiotensin-Converting Enzyme 2 upon Liver- and Lung-Targeted Delivery of Optimized Chemically Modified mRNA

Molecular Therapy: Nucleic Acids, 2017
Changes in lifestyle and environmental conditions give rise to an increasing prevalence of liver and lung fibrosis, and both have a poor prognosis.
Eva Schrom, Maja Huber, Manish Aneja, Christian Dohmen, Daniela Emrich, Johannes Geiger, Günther Hasenpusch, Annika Herrmann-Janson, Verena Kretzschmann, Olga Mykhailyk, Tamara Pasewald, Prajakta Oak, Anne Hilgendorff, Dirk Wohlleber, Heinz-Gerd Hoymann, Dirk Schaudien, Christian Plank, Carsten Rudolph, Rebekka Kubisch-Dohmen   +18 more
doaj   +1 more source

RNA interference approaches for treatment of HIV-1 infection. [PDF]

, 2015
HIV/AIDS is a chronic and debilitating disease that cannot be cured with current antiretroviral drugs. While combinatorial antiretroviral therapy (cART) can potently suppress HIV-1 replication and delay the onset of AIDS, viral mutagenesis often leads to
Bobbin, Maggie L, Burnett, John C, Rossi, John J   +2 more
core   +1 more source

Altered cellular and humoral immune responses following SARS-CoV-2 mRNA vaccination in patients with multiple sclerosis on anti-CD20 therapy.

medRxiv, 2021
SARS-CoV-2 mRNA vaccination in healthy individuals generates effective immune protection against COVID-19. Little is known, however, about the SARS-CoV-2 mRNA vaccine-induced responses in immunosuppressed patients.
Sokratis A. Apostolidis, Mihir Kakara, Mark M. Painter, R. Goel, D. Mathew, Kerry Lenzi, Ayman Z. Rezk, K. Patterson, Diego A. Espinoza, Jessy C. Kadri, Daniel M. Markowitz, Clyde Markowitz, Ina Mexhitaj, D. Jacobs, Allison Babb, M. Betts, E. Prak, D. Weiskopf, A. Grifoni, Kendall A. Lundgreen, S. Gouma, A. Sette, Paul Bates, S. Hensley, A. Greenplate, E. Wherry, Rui Li, A. Bar-Or   +27 more
semanticscholar   +1 more source

Dopamine receptor DRD1 expression (mRNA, protein level) in peripheral blood lymphocytes and prognosis of antipsychotic therapy

Учёные записки Санкт-Петербургского государственного медицинского университета им. Акад. И.П. Павлова, 2022
Introduction. There is a problem in predicting the efficacy and safety of antipsychotic therapy. Dopamine receptor D1 is one of the targets of antipsychotics.
A. M. Zabotina, A. S. Zhuravlev, M. N. Grunina, R. F. Nasyrova, E. V. Volkova, A. A. Tyurin, O. V. Limankin, A. P. Otmakhov, E. M. Krupitsky, N. G. Neznanov, A. E. Taraskina   +10 more
doaj   +1 more source

ALKBH5-mediated m6A demethylation of GLUT4 mRNA promotes glycolysis and resistance to HER2-targeted therapy in breast cancer.

Cancer Research, 2022
Resistance to HER2-targeted therapy represents a significant challenge for the successful treatment of breast cancer patients with HER2-positive tumors.
H. Liu, H. Lyu, Guanmin Jiang, Danyang Chen, S. Ruan, Shuang Liu, Lukun Zhou, Mingqiang Yang, Shanshan Zeng, Zhiming He, Hongsheng Wang, Hongsheng Li, G. Zheng, Bolin Liu   +13 more
semanticscholar   +1 more source

Targeting strategies for mRNA delivery

Materials Today Advances, 2022
mRNA gene therapy has recently emerged as a candidate to enable multiple therapeutic applications including protein replacement therapy, vaccine immunology, and regenerative medicine.
Randall A. Meyer, Sarah Y. Neshat, Jordan J. Green, Jose Luis Santos, Anthony D. Tuesca   +4 more
doaj   +1 more source

Personalized pancreatic cancer therapy: from the perspective of mRNA vaccine

Military Medical Research, 2022
Pancreatic cancer is characterized by inter-tumoral and intra-tumoral heterogeneity, especially in genetic alteration and microenvironment. Conventional therapeutic strategies for pancreatic cancer usually suffer resistance, highlighting the necessity ...
Xing Huang, Gang Zhang, Tianyu Tang, Xiang Gao, T. Liang   +4 more
semanticscholar   +1 more source

Cannabinoid receptor CB2 drives HER2 pro-oncogenic signaling in breast cancer [PDF]

, 2015
Pharmacological activation of cannabinoid receptors elicits antitumoral responses in different models of cancer. However, the biological role of these receptors in tumor physio-pathology is still unknown.
Alkatout, Ibrahim, Andradas, Clara, Arnold, Norbert, Artola, Marta, Bauer, Maret, Blasco-Benito, Sandra, Bronsert, Peter, Caffarel, María M., Canela, Enric I., Fernández-Piqueras, José, Flores, Juana M., García-Taboada, Elena, Guzmán, Manuel, Hamann, Sigrid, Klapper, Wolfram, Martín-Villar, Ester, McCormick, Peter J., Megías, Diego, Moreno, Estefanía, Moreno-Bueno, Gema, Ortega-Gutiérrez, Silvia, Pérez-Gómez, Eduardo, Pérez-Martínez, Manuel, Quintanilla, Miguel, Röcken, Christoph, Soriano, Joaquim, Staebler, Annette, Stickeler, Elmar, Sánchez, Cristina, Villa-Morales, María, Vázquez-Villa, Henar, Wenners, Antonia   +31 more
core   +1 more source

mRNA-based therapies and their clinical prospects [PDF]

Chinese Science Bulletin, 2021
The striking effectiveness of messenger ribonucleic acid (mRNA) vaccines against coronavirus disease 2019 (COVID-19) not only offers hope to end the current pandemic, but also presents mRNA-based therapeutics as a potential new treatment class that may help in the fight against other diseases.
Chenyue Hang, Shanshan Xu, Qifeng Wu, Puyu Zhang, Yu Zhang, Yingjie Xu   +5 more
openaire   +1 more source