Results 71 to 80 of about 797,089 (324)
mRNA vaccines as cancer therapies
Chinese Medical JournalAbstract Cancer remains a major global health challenge, with conventional treatments like chemotherapy and radiotherapy often hindered by significant side effects, lack of specificity, and limited efficacy in advanced cases.
Shaoxiong Huang +4 more
openaire +3 more sources
Clinical development of mRNA therapies against solid tumors
Journal of Hematology & Oncology, 2023 AbstractThe mRNA-based therapeutics have become the hot spot of biopharmaceutical industries in recent years. The landscape of this area is expanding from infectious disease to cancer, which needs to be summarized to provide data supports for industries and research institutions.
Dawei Wu +10 more
openaire +3 more sources
Nanomaterials for mRNA‐based therapeutics: Challenges and opportunities
Bioengineering & Translational Medicine, 2023 Messenger RNA (mRNA) holds great potential in developing immunotherapy, protein replacement, and genome editing. In general, mRNA does not have the risk of being incorporated into the host genome and does not need to enter the nucleus for transfection ...
De‐feng Li +10 more
doaj +1 more source
Mutated TP53 is a marker of increased VEGF expression: analysis of 7,525 pan-cancer tissues. [PDF]
, 2020 Anti-angiogenic therapies are an important class of anti-cancer treatment drugs. However, their efficacy is limited to certain tumors and would benefit from identifying a biomarker predictive of therapeutic response.
Boichard, Amélie +2 more
core
The human ankyrin 1 promoter insulator sustains gene expression in a β-globin lentiviral vector in hematopoietic stem cells. [PDF]
, 2015 Lentiviral vectors designed for the treatment of the hemoglobinopathies require the inclusion of regulatory and strong enhancer elements to achieve sufficient expression of the β-globin transgene.
Baldwin, Kismet M +12 more
core +4 more sources
Transplantation and Cellular Therapy, 2021 Data are scarce regarding both safety and immunogenicity of the BNT162b2 mRNA COVID-19 vaccine in patients undergoing immune cell therapy, thus we prospectively evaluated these 2 domains in patients receiving this vaccine after allogeneic HCT (n=66) or
R. Ram +19 more
semanticscholar +1 more source
Small StructuresmRNA‐loaded lipid nanoparticles (LNPs) offer significant therapeutic potential for various diseases, yet their structural characteristics and component distribution remain incompletely understood. This study utilizes small‐angle neutron scattering (SANS)
Haikun Liu +12 more
doaj +1 more source
By dawn or dusk—how circadian timing rewrites bacterial infection outcomes
FEBS Letters, EarlyView.The circadian clock shapes immune function, yet its influence on infection outcomes is only beginning to be understood. This review highlights how circadian timing alters host responses to the bacterial pathogens Salmonella enterica, Listeria monocytogenes, and Streptococcus pneumoniae revealing that the effectiveness of immune defense depends not only
Devons Mo +2 more
wiley +1 more source
Small StructuresBlood‐ and blood cell‐derived colloidal materials are gaining traction as platforms for targeted therapeutics, imaging, and theranostics. To fully exploit their potential, high‐resolution insight into their structural and compositional features is ...
Cuong Viet Pham +10 more
doaj +1 more source
Clinical and Developmental Immunology, 2011 Cell division is closely related to telomerase activity (hTERT mRNA). Lower expression of lymphocitic hTERT mRNA may easily cause cell aging, which is not beneficial to maintaining a durable lymphocyte division.
Chuan-wu Zhu +10 more
doaj +1 more source