Results 161 to 170 of about 1,686,414 (204)

A Self-amplifying mRNA vaccine for infectious laryngotracheitis virus (ILTV) induces efficient protective immunity. [PDF]

Poult Sci
Li HH, Tong L, Chen SS, Bi ZX, Hu G, Chen WL, Yu JL, Tao RN, Huang T, Xia SH, Osterrieder N, Wang JC.   +11 more
europepmc   +1 more source

A lipid nanoparticle-based mRNA vaccine elicits immunity against porcine circovirus type 2 in mice. [PDF]

Microbiol Spectr
Nie J, Tian C, Huang H, Gang J, Chen Y, Ji M, Sun J, Zhou Y, Liu L, Tai W.   +9 more
europepmc   +1 more source

mRNA Vaccine Against Japanese Encephalitis Virus Genotype IV Protects Against Lethal Infection. [PDF]

Viruses
Cox AL, Nguyen W, Wales-Earl L, Tang B, Yan K, Peters J, Khromykh AA, Tropée R, McMillan NAJ, Suhrbier A, Rawle DJ.   +10 more
europepmc   +1 more source

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The Quest for mRNA Vaccines

Nucleic Acid Therapeutics, 2022
The success of mRNA vaccines against COVID-19 is nothing short of a medical revolution. Given its chemical lability the use of mRNA as a therapeutic has been counterintuitive and met with skepticism. The development of mRNA-based COVID-19 vaccines was the culmination of long and painstaking efforts by many investigators spanning ...
Eli, Gilboa, David, Boczkowski, Smita K, Nair   +2 more
openaire   +2 more sources

mRNA vaccines

Nature Biotechnology, 2021
The concept of developing mRNA as vaccine platform evolved over the last decades. mRNA uses host cells for antigen production, can induce B and T cell responses and does not rely on unwanted antigens that may interfere with booster doses like vector vaccines.
openaire   +3 more sources

An mRNA vaccine for influenza

Nature Biotechnology, 2012
An influenza vaccine made of stabilized mRNA may allow vaccine design and manufacture to keep pace with viral evolution.
Sook-San, Wong, Richard J, Webby
openaire   +2 more sources

Innate sensing of mRNA vaccines

Current Opinion in Immunology, 2022
With the recent success of mRNA vaccines and the approval of several RNA oligonucleotide therapeutics, RNA holds great promise for future drug development. The rise of RNA therapeutics has been enabled by the tremendous progress in our understanding of the sophisticated cellular mechanisms that disarm potentially dangerous exogenous RNA and safeguard ...
Christine, Wuebben, Eva, Bartok, Gunther, Hartmann   +2 more
openaire   +2 more sources

mRNA Cancer Vaccines

2016
mRNA cancer vaccines are a relatively new class of vaccines, which combine the potential of mRNA to encode for almost any protein with an excellent safety profile and a flexible production process. The most straightforward use of mRNA vaccines in oncologic settings is the immunization of patients with mRNA vaccines encoding tumor-associated antigens ...
Katja, Fiedler, Sandra, Lazzaro, Johannes, Lutz, Susanne, Rauch, Regina, Heidenreich   +4 more
openaire   +2 more sources

A noninflammatory mRNA vaccine for treatment of experimental autoimmune encephalomyelitis

Science, 2021
Precision therapy for immune tolerance Autoimmune diseases, such as multiple sclerosis (MS), result from a breach of immunological self-tolerance and tissue damage by autoreactive T lymphocytes.
C. Krienke, Laura Kolb, Elif Diken, M. Streuber, S. Kirchhoff, Thomas Bukur, Özlem Akilli-Öztürk, L. Kranz, Hendrik Berger, J. Petschenka, M. Diken, S. Kreiter, N. Yogev, A. Waisman, K. Karikó, Ö. Türeci, U. Şahin   +16 more
semanticscholar   +1 more source

Developing mRNA-vaccine technologies [PDF]

RNA Biology, 2012
mRNA vaccines combine desirable immunological properties with an outstanding safety profile and the unmet flexibility of genetic vaccines. Based on in situ protein expression, mRNA vaccines are capable of inducing a balanced immune response comprising both cellular and humoral immunity while not subject to MHC haplotype restriction.
Thomas Schlake, Andreas Thes, Mariola Fotin-Mleczek   +2 more
exaly   +3 more sources