Results 181 to 190 of about 1,686,414 (204)

Adjuvant-Enhanced mRNA Vaccines

2016
Recent advances in molecular biology have led to dramatic enhancement of the stability of in vitro transcribed (IVT) messenger RNA (mRNA) and improvement in its translational efficacy. Nowadays, mRNA-based vaccines represent a promising approach in the field of anticancer immunotherapy, gaining attention over the earlier-established bacteria-, virus ...
Bialkowski, Lukasz, Van Der Jeught, Kevin, Renmans, Dries, van Weijnen, Alexia, Heirman, Carlo, Keyaerts, Marleen, Breckpot, Karine, Thielemans, Kris   +7 more
openaire   +2 more sources

Computational design of mRNA vaccines

Vaccine
mRNA technology has emerged as a successful vaccine platform that offered a swift response to the COVID-19 pandemic. Accumulating evidence shows that vaccine efficacy, thermostability, and other important properties, are largely impacted by intrinsic properties of the mRNA molecule, such as RNA sequence and structure, both of which can be optimized ...
Yoo-Ah, Kim, Kambiz, Mousavi, Amirali, Yazdi, Magda, Zwierzyna, Marco, Cardinali, Dillion, Fox, Thomas, Peel, Jeff, Coller, Kunal, Aggarwal, Giulietta, Maruggi   +9 more
openaire   +2 more sources

mRNA vaccines in the rheumatologist's future

Seminars in Arthritis and Rheumatism
Vaccines taking advantage of mRNA technology have been long in development.To review the status of approved mRNA vaccines for infectious diseases as well as those in development.Systematic literature review of clinical and immunologic studies of mRNA vaccines against infectious diseases.Currently approved mRNA vaccines include those against SARS CoV-2 ...
openaire   +2 more sources

COVID-19 vaccine mRNA-1273 elicits a protective immune profile in mice that is not associated with vaccine-enhanced disease upon SARS-CoV-2 challenge

Immunity, 2021
Anthony T Dipiazza, Sarah R Leist, Olubukola M Abiona   +2 more
exaly  

Adjuvant-pulsed mRNA vaccine nanoparticle for immunoprophylactic and therapeutic tumor suppression in mice

Biomaterials, 2021
Mohammad Ariful Islam, Harshal Zope, Wei Tao   +2 more
exaly  

Vaccination with Messenger RNA (mRNA)

2008
Both DNA and mRNA can be used as vehicles for gene therapy. Because the immune system is naturally activated by foreign nucleic acids thanks to the presence of Toll-like Receptors (TLR) in endosomes (TLR3, 7, and 8 detect exogenous RNA, while TLR9 can detect exogenous DNA), the delivery of foreign nucleic acids usually induces an immune response ...
openaire   +2 more sources

Impact of lipid nanoparticle size on mRNA vaccine immunogenicity

Journal of Controlled Release, 2021
Chiaowen Joyce Hsiao, Melissa J Moore, Luis A Brito   +2 more
exaly  

Suppressing autoimmunity with mRNA vaccines

Nature Reviews Drug Discovery, 2021
openaire   +2 more sources

Lipid nanoparticle-mediated lymph node–targeting delivery of mRNA cancer vaccine elicits robust CD8 + T cell response

Proceedings of the National Academy of Sciences of the United States of America, 2022
Jinjin Chen, Zhongfeng Ye, Min Qiu
exaly  

mRNA Vaccines

2022
openaire   +1 more source