Results 171 to 180 of about 199,785 (356)

Bell's palsy as a possible complication of mRNA-1273 (Moderna) vaccine against COVID-19

, 2022
Sujan Poudel, Prakash Nepali, Santosh Baniya, Sangam Shah, Sunil Bogati, Gaurav Nepal, Rajeev Ojha, Omoyeme Edaki, Gavrilo Lazovic, Sam Kara   +9 more
openalex   +1 more source

Advanced Human Immune Cell‐Organoid Co‐Cultures for Functional Testing of Cancer Nanovaccines

Advanced Science, EarlyView.
Pancreatic ductal adenocarcinoma remains difficult to treat. We establish an organoid–immune co‐culture using patient‐derived organoids and matched T‐cells to assess cancer vaccines. A mesothelin‐targeted nanovaccine activates antigen‐specific T‐cells, increases IFN‐γ, and targets MSLN+ organoids.
Nathalia Ferreira, David Agorku, Andre Rosa, Julia Roosz, Lena Christ, Nicole Anderle, Ajinkya Kulkarni, Abir Hussein, Sana S. Sayedipour, Omar F. Luna, Tobias Legler, Philipp Ströbel, Fernando Albericio, Luis Cruz, Phillipp Beckhove, Peter Loskill, Frauke Alves, M. Andrea Markus, Fernanda Ramos‐Gomes   +18 more
wiley   +1 more source

Lipid nanoparticle-delivered mRNA vaccine encoding the MOMP of Chlamydia psittaci elicits protective immune responses in BALB/c mice

Microbiology Spectrum
Chlamydia psittaci is an important pathogenic zoonotic pathogen that infects birds and can be transmitted to humans and other animals. This research focused on creating an mRNA vaccine targeting C.
Buwei Wang, Jian Xiao, Jiewen Wang, Wanying Zhang, Yinqi Jin, Yalan Jiang, Yuqing Chen, Zhangping He, Aihua Lei, Chunxue Lu, Chuan Wang   +10 more
doaj   +1 more source

2729. mRNA Vaccines Encoding Conserved Influenza Antigens Induce Robust and Durable Immunity in Rhesus Macaques [PDF]

, 2019
Jessica A. Flynn, Kara S. Cox, Sinoeun Touch, Yangsi Ou, Teresa Weber, Michael Citron, Kapil Bahl, Giuseppe Ciaramella, Amy S. Espeseth, Lan Zhang   +9 more
openalex   +1 more source

Targeting Lactate and Lactylation in Cancer Metabolism and Immunotherapy

Advanced Science, EarlyView.
Lactate, once deemed a metabolic waste, emerges as a central regulator of cancer progression. This review elucidates how lactate and its epigenetic derivative, protein lactylation, orchestrate tumor metabolism, immune suppression, and therapeutic resistance.
Jiajing Gong, Yuhang Xie, Zhijie Weng, Yongzhi Wu, Longjiang Li, Bo Li   +5 more
wiley   +1 more source

Vaccination with either mRNA or Vector-Based COVID-19 Vaccine has no Detectable Effect on Sperm Parameters

, 2022
Philippos Edimiris, Cornelius Doehmen, Lisa Mueller, Marcel Andrée, Dunja Maria Baston-Büst, Sebastian Buest, Ortwin Adams, Jan-Steffen Kruessel, Alexandra P. Bielfeld   +8 more
openalex   +1 more source

Soft‐Drug‐Inspired MnSTF Nano‐Adjuvant for Safe and Synergistic cGAS–STING Activation in Tumor Immunotherapy

Advanced Science, EarlyView.
This study introduces MnSTF, a soft‐drug‐inspired nanoadjuvant that overcomes the systemic toxicity of STING agonists. Through Mn2+ coordination with an ENPP1 inhibitor, it enables safe cGAS‐STING activation, remodels the tumor immune microenvironment, and synergizes with radiotherapy or vaccines to elicit robust antitumor immunity.
Guangfei Sun, Jiancheng Pan, Rui Li, Ruoxi Li, Ziyan Liu, Jinhui Wu, Tingsheng Lin, Yiqiao Hu, Ahu Yuan   +8 more
wiley   +1 more source

Innate immune responses against mRNA vaccine promote cellular immunity through IFN-β at the injection site

Nature Communications
mRNA vaccines against SARS-CoV-2 have revolutionized vaccine development, but their immunological mechanisms are not fully understood. Here, we investigate injection site responses of mRNA vaccines by generating a comprehensive single-cell transcriptome ...
Seongryong Kim, Ji Hyang Jeon, Myeonghwan Kim, Yeji Lee, Yun-Ho Hwang, Myungsun Park, C. Han Li, Taeyoung Lee, Jung-Ah Lee, You-Me Kim, Dokeun Kim, Hyukjin Lee, You-Jin Kim, V. Narry Kim, Jong-Eun Park, Jinah Yeo   +15 more
doaj   +1 more source

Waning effectiveness of mRNA COVID-19 vaccines against inpatient and emergency department encounters.

PLoS ONE
In the United States, most real-world estimates of COVID-19 vaccine effectiveness are based on data drawn from large health systems or sentinel populations.
Theodoros V Giannouchos, Nicole L Hair, Bankole Olatosi, Xiaoming Li   +3 more
doaj   +1 more source

Safe administration of subsequent mRNA COVID‐19 vaccine doses following a possible allergic reaction to the first dose

, 2022
Michèle Roth, Sibylla Chantraine, Carlos A. Morales Mateluna, Karin Hartmann, Christoph Berger   +4 more
openalex   +2 more sources