Results 51 to 60 of about 117,359 (326)

The MRP gene encodes an ATP-dependent export pump for leukotriene C4 and structurally related conjugates.

open access: yesJournal of Biological Chemistry, 1994
The multidrug resistance-associated protein (MRP) is the product of an ATP-binding cassette transporter gene overexpressed in some tumor cells resistant to antineoplastic agents. We studied the transport function of MRP in membrane vesicles prepared from
I. Leier   +5 more
semanticscholar   +1 more source

AI chatbots show promise but limitations on UK medical exam questions: a comparative performance study

open access: yesScientific Reports
Large language models (LLMs) like ChatGPT have potential applications in medical education such as helping students study for their licensing exams by discussing unclear questions with them. However, they require evaluation on these complex tasks.
Mohammed Ahmed Sadeq   +11 more
doaj   +1 more source

Development of taxane resistance in a panel of human lung cancer cell lines [PDF]

open access: yes, 2008
Using a selection process designed to reflect clinically relevant conditions, a panel of taxane-selected variants were developed to study further the mechanisms of resistance in lung cancer.
Breen, Laura   +3 more
core   +1 more source

Self‐Regulating Sodium‐Ion Battery Materials: From Phase Reconstruction to Functional Activation

open access: yesAdvanced Materials, EarlyView.
Self‐regulating sodium‐ion batteries hinge on programmable phase behavior in layered oxides, interphases that renew without growth, and electrolytes that steer solvation and chemistry. This review distills mechanisms into design rules that span composition, site and entropy tuning, and self‐buffering anodes, linking operando evidence to choices and ...
Hong Gao   +10 more
wiley   +1 more source

Medication-related problem type and appearance rate in ambulatory hemodialysis patients

open access: yesBMC Nephrology, 2003
Background Hemodialysis (HD) patients are at risk for medication-related problems (MRP). The MRP number, type, and appearance rate over time in ambulatory HD patients has not been investigated.
Drayer Debra K   +2 more
doaj   +1 more source

Use of RNA secondary structure for evolutionary relationships : investigating RNase P and RNase MRP : a thesis presented in partial fulfilment of the requirements for the degree of Master of Science in Genetics at Massey University, New Zealand [PDF]

open access: yes, 1998
Bioinformatics is applied here to examine whether RNA secondary structure data can reflect distant evolutionary relationships. This is important when there is little confidence in sequence data such as when looking at the evolution of RNase MRP (MRP ...
Collins, Lesley Joan
core  

POU2F1 Promotes Chemoresistance in Colorectal Cancer Cells via Attenuates the MDR2 Degradation Mediated by PPP1R11 Lactylation

open access: yesAdvanced Science, EarlyView.
Schematic diagram of our study showing that highly expressed POU2F1 in colorectal cancer (CRC) can directly accelerate the cytosolic lactate export to decrease PPP1R11 lactylation at K59, thereby attenuating the E3 ligase enzyme activity and protein stability of PPP1R11, which inhibits the ubiquitination of MDR2 at K413 and K538 but increases the ...
Longzheng Xia   +8 more
wiley   +1 more source

Evaluation of Using Semi-Autonomy Features in Mobile Robotic Telepresence Systems [PDF]

open access: yes, 2015
Mobile robotic telepresence systems used for social interaction scenarios require that users steer robots in a remote environment. As a consequence, a heavy workload can be put on users if they are unfamiliar with using robotic telepresence units.
Coradeschi, Silvia   +6 more
core   +2 more sources

The Jury's Still Out on What Constitutes a Microaggression [PDF]

open access: yes, 2018
In "Microaggressions: Strong Claims, Inadequate Evidence," Scott Lillenfeld argues that, despite a decade of scholarship, the Microaggression Research Program (MRP) continues to suffer serious analytic and evidentiary problems.
Al-Gharbi, Musa
core  

Bayesian multitask inverse reinforcement learning [PDF]

open access: yes, 2011
We generalise the problem of inverse reinforcement learning to multiple tasks, from multiple demonstrations. Each one may represent one expert trying to solve a different task, or as different experts trying to solve the same task.
C.A. Rothkopf   +3 more
core   +4 more sources

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