Results 81 to 90 of about 21,470 (243)

m6A‐Mediated Stabilization of MRPS23 Drives NSCLC Progression Via HSPA8 and ERK Signaling Modulation

Cancer Science, EarlyView.
MRPS23 mRNA is m6A‐methylated by WTAP and stabilized by IGF2BP3, leading to increased MRPS23 protein. MRPS23 physically interacts with HSPA8, and this interaction is functionally associated with activation of the RAS–RAF–MEK–ERK pathway, ultimately promoting NSCLC cell proliferation and tumor progression.
Sihong Le, Yitao Le, Xianshen Sha, Feng Qiu, Ling Zhang   +4 more
wiley   +1 more source

Tumor‐Resident Microbiota‐Based Risk Model Predicts Neoadjuvant Therapy Response of Locally Advanced Esophageal Squamous Cell Carcinoma Patients

Advanced Science
Few predictive biomarkers exist for identifying patients who may benefit from neoadjuvant therapy (NAT). The intratumoral microbial composition is comprehensively profiled to predict the efficacy and prognosis of patients with esophageal squamous cell ...
Hong Wu, Qianshi Liu, Jingpei Li, Xuefeng Leng, Yazhou He, Yiqiang Liu, Xia Zhang, Yujie Ouyang, Yang Liu, Wenhua Liang, Chuan Xu   +10 more
doaj   +1 more source

Investigation of the MRP/MRP II implementation in manufacturing companies in Türkiye [PDF]

, 1995
75
openaire   +1 more source

3D Character Reconstruction from Hand‐drawn Model Sheets

Computer Graphics Forum, EarlyView.
Abstract Hand‐drawn model sheets are widely used in character design to define 3D shape and appearance through sparse multi‐view drawings. Reconstructing 3D characters from such sparse inputs has traditionally been challenging due to insufficient visual information.
Hyejeong Yoon, Wonjong Jang, Yoonha Hwang, Seungyong Lee   +3 more
wiley   +1 more source

Multivariate MRP

Measuring public opinion at subnational geographies is critical to many theories in political science. Multilevel regression and post-stratification (MRP) is a popular tool for doing so, although existing work is limited to measuring opinion on a single survey question. We provide a framework for estimating the joint distribution of opinion on multiple
Goplerud, Max, Auslen, Michael
openaire   +2 more sources

Effect of interdisciplinary obesity care on metabolic markers and body weight in people with type 2 diabetes in a rural setting: A randomised controlled trial

Clinical Obesity, Volume 15, Issue 2, April 2025.
Summary Management of type 2 diabetes includes medications that can unintentionally increase obesity and insulin resistance. This unblinded, single‐centre, randomised controlled trial focused on rural Australian adults with type 2 diabetes (aged 18–75 and body mass index [BMI] >30 kg/m2), measuring the effectiveness of a tailored interdisciplinary ...
Giuliana O. Murfet, Iain K. Robertson, Sharon P. Luccisano, Michelle L. Kilpatrick   +3 more
wiley   +1 more source

Identification of RMP24 and RMP64, human ribonuclease MRP-specific protein components

Cell Reports
Summary: Human RNase MRP is a ribonucleoprotein (RNP) enzyme that processes precursor rRNA (pre-rRNA) at ITS1 site 2 and may have additional activities. It is an endonuclease related to RNase P, which processes pre-tRNAs and pre-tRNA-like substrates.
Rui Che, Bhoomi Mirani, Monireh Panah, Xiaotong Chen, Hong Luo, Andrei Alexandrov   +5 more
doaj   +1 more source

Prevalence of peripheral dental caries and diastemata in horses fed high‐carbohydrate diets

Equine Veterinary Education, EarlyView.
Summary Background Peripheral dental caries and diastemata impair equine oral health. Diets rich in soluble carbohydrates are suspected risk factors, but few studies have assessed their impact. In Brazil, sugarcane is widely used as a forage source due to its availability and low cost.
S. L. Paredes, R. P. Mendes, M. D. Lacerenza, R. G. S. Dória, J. d. A. Arantes, L. S. B. Silva, R. R. Corrêa   +6 more
wiley   +1 more source

Understanding and addressing resistance to IMiDs immunomodulatory compounds in multiple myeloma

The FEBS Journal, EarlyView.
IMiDs are pivotal in the treatment of multiple myeloma. Mechanisms of resistance comprise cell intrinsic and extrinsic pathways, involving tumour microenvironment, immune cell dysfunction, CRBN‐dependent and independent genetic drivers and epigenetic changes.
Maria‐Cynthia Fuentes‐Lacouture, Devi Nandana, Karthik Ramasamy, Anjan Thakurta   +3 more
wiley   +1 more source

Risk Perceptions and Corporate Financing Behavior

Financial Management, EarlyView.
ABSTRACT Using a recently developed measure of financial market risk perceptions, we show that risk perceptions affect firm‐level corporate financing behavior. Firms tend to adjust their capital structures to cater to investors' appetite for risk. When perceived risks are low, firms tend to choose more leveraged capital structures to take advantage of ...
Youngmin Choi, Armen Hovakimian, Joonsung Won   +2 more
wiley   +1 more source