Results 91 to 100 of about 88,694 (296)

Efficacy of Essential Oil of Algrizea minor Sobral, Faria & Proença (Myrtaceae) in Combating Methicillin‐resistant Staphylococcus aureus: Antibacterial and Virulence Modulation Studies Conducted In Vitro and In Vivo

open access: yesChemistry &Biodiversity, EarlyView.
This study explored the antibacterial, antivirulence, and in vivo effects of Algrizea minor essential oil (EOAM), against MRSA isolates. Chemical analysis by GC‐MS has been performed. The oil exhibited synergistic effects when combined with amoxicillin and oxacillin, inhibiting biofilm formation and reducing S. aureus‐induced hemolysis.
Amanda Vieira de Barros   +14 more
wiley   +1 more source

Emergence of Methicillin-Resistant Staphylococcus aureus Belonging to Clonal Complex 15 (CC15-MRSA) in Kuwait Hospitals

open access: yesInfection and Drug Resistance, 2020
Edet E Udo, Samar S Boswihi, Bindu Mathew, Bobby Noronha, Tina Verghese, Aisha Al-Jemaz, Fatma Al Saqer Department of Microbiology, Faculty of Medicine, Kuwait University, Safat, KuwaitCorrespondence: Edet E UdoDepartment of Microbiology, Faculty of ...
Udo EE   +6 more
doaj  

Potential of the Introduction of Tedizolid for the Treatment of Complicated Skin and Soft Tissue Infections in a Russian Multi-Field Hospital [PDF]

open access: yesКлиническая микробиология и антимикробная химиотерапия, 2016
Increase in prevalence of methicillin-resistant Staphylococcus aureus (MRSA) strains among the pathogens of complicated skin and soft tissue infections (cSSTIs) in hospitalised patients demands introduction of new treatment options with improved efficacy
Belkova Yu.А.   +5 more
doaj  

Harnessing Organometallic Au(III) Complexes as Precision Scaffolds for Next‐Generation Therapeutic and Imaging Agents

open access: yesChemBioChem, EarlyView.
Cyclometalated gold(III) complexes offer a versatile platform for selective biological interactions, including cysteine arylation, redox modulation, and enzyme inhibition. This review explores their roles in anticancer, antimicrobial, and protein modification strategies, highlighting their ability to disrupt metabolic pathways, modulate aquaporins, and
Sophie R. Thomas, Riccardo Bonsignore
wiley   +1 more source

Boosting Antibiotic Efficacy of Azole Drugs against Methicillin‐Resistant Staphylococcus Aureus by Coordination to Rhenium Carbonyl Complexes

open access: yesChemBioChem, EarlyView.
Coordination of antifungal azoles to rhenium di‐ and tricarbonyl complexes results in compounds with enhanced antimicrobial efficacy—up to 32‐fold minimum inhibitory concentration improvement—against methicillin‐sensitive and methicillin‐resistant Staphylococcus aureus over parent azoles.
Kevin Schindler   +12 more
wiley   +1 more source

An Investigation of Toxic Shock Syndrome Toxin-1 Gene in Methicillin-Resistant Clinical Strains of Staphylococcus aureus using Multiplex PCR Method

open access: yesMajallah-i Dānishgāh-i ̒Ulūm-i Pizishkī-i Qum, 2017
Background and Objectives: Toxins produced by the bacteria are one of the most common cases, which can, together with other bacterial pathogens, cause or aggravate the disease. One of the diseases caused by bacterial toxins, is toxic shock syndrome.
mohammad bokaiean   +3 more
doaj  

Synthesis and Biological Evaluation of Bicyclic Pyrazolines with Promising Antimicrobial Activities

open access: yesChemMedChem, EarlyView.
Continuous flow technology is exploited for the generation of bicyclic pyrazolines via photo‐click reactions. These heterocyclic species contain a valuable 3D scaffold along with a polar succinimide moiety. Subsequent antimicrobial testing reveals that halogenated moieties such as chlorine atoms and trifluoromethoxy groups enhance the potency of these ...
Debora Caviglia   +4 more
wiley   +1 more source

Staphylococcus Aureus Carriage among Healthcare Workers in Burn and Surgical Critical Care Units in Menoufia University Hospital, Egypt

open access: yesJournal of High Institute of Public Health, 2015
Objectives: This study aimed to investigate Staphylococcal aureus (S. aureus) carriage among healthcare workers (HCWs) in Burn and Surgical Critical Care Units in Menoufia University Hospital, Egypt, following an outbreak of S.
Eman A. Salem   +2 more
doaj   +1 more source

Impact of Model‐Informed Drug Development on Drug Development Cycle Times and Clinical Trial Cost

open access: yesClinical Pharmacology &Therapeutics, EarlyView.
Model‐informed drug development (MIDD) integrates data to quantify benefit/risk informing objective drug discovery and development decisions. An additional critical benefit of MIDD is postulated to be improvement in trial and program efficiencies. While the application of MIDD has grown, there have been no clear examples across programs to demonstrate ...
Vaishali Sahasrabudhe   +4 more
wiley   +1 more source

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