Results 101 to 110 of about 88,694 (296)

Microbiome‐Informed Dosing: Exploring Gut Microbial Communities Impact on Mycophenolate Enterohepatic Circulation and Therapeutic Target Achievement

open access: yesClinical Pharmacology &Therapeutics, EarlyView.
Pharmacomicrobiomics is an emerging field due to important microbiome effects on pharmacokinetics and clinical outcomes. However, the application of this knowledge remains limited. Mycophenolic acid (MPA) is the primary active metabolite of the immunosuppressant, mycophenolate mofetil (MMF).
Abdelrahman Saqr   +4 more
wiley   +1 more source

Antimicrobial Resistance and Molecular Characteristics of Methicillin-resistant Staphylococcus aureus Isolates from Children Patients in Iran

open access: yesInfection and Drug Resistance, 2019
Roghayeh Samadi,1 Zohreh Ghalavand,1 Reza Mirnejad,2 Bahram Nikmanesh,3 Gita Eslami1 1Department of Microbiology, School of Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran; 2Molecular Biology Research Center, Systems Biology and ...
Samadi R   +4 more
doaj  

Synthetic Biology‐Based Engineering Living Therapeutics for Antimicrobial Application

open access: yesExploration, EarlyView.
This perspective highlights synthetic biology‐driven antibacterial strategies, focusing on three innovative approaches: engineered bacteriophages for precision bacterial targeting, reprogrammed microbes that detect quorum‐sensing signals or metabolites to release antimicrobials, and engineering mammalian cells that recognize pathogen‐associated ...
Shun Huang   +4 more
wiley   +1 more source

Absence Of Methicillin-Resistant Staphylococcus aureus (MRSA) In Cattle From Portugal: A One Health Approach

open access: yesInfection and Drug Resistance, 2019
Susana Correia,1–4 Vanessa Silva,1–4 Juan García-Díez,5 Paula Teixeira,6 Kevin Pimenta,1–4 María Teresa Tejedor-Junco,7 Soraia Oliveira,1–4 Gilberto Igrejas,2–4 Patricia Poeta1,4 1Microbiology and ...
Correia S   +8 more
doaj  

Emerging Target Discovery Strategies Drive the Decoding of Therapeutic Power of Natural Products and Further Drug Development: A Case Study of Celastrol

open access: yesExploration, EarlyView.
Using celastrol as a case study, this review summarizes various target discovery strategies for natural products, including chemical proteomics, protein microarray, degradation‐based protein profiling, proteome‐wide label‐free approaches, network pharmacology, target‐based drug screening, and indirect strategies.
Yanbei Tu   +5 more
wiley   +1 more source

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