Results 51 to 60 of about 126,895 (241)

STING/Type I Interferon Pathway Activation Confers Multimodal Therapeutic Benefits in Osteomyelitis

Advanced Science, EarlyView.
STING/type I interferon signaling counteracts osteomyelitis through coordinated control of pain, bone destruction, and abscess formation. It inhibits pathogen‐induced nociceptor activation, restrains osteoclast‐mediated bone resorption, and suppresses IL‐1β‐driven neutrophil recruitment.
Yang Chen, Jianhua Lv, Yuanqing Cai, Xuhui Yuan, Hongxin Hu, Jiayu Li, Yiming Lin, Hongyan Li, Lan Lin, Huangfeng Lin, Chaofan Zhang, Qijin Wang, Ying Huang, Zida Huang, Wenbo Li, Susheng Niu, Jianhua Lin, Bin Yang, Xinyu Fang, Wenming Zhang   +19 more
wiley   +1 more source

Monitoring environmental cleanliness on two surgical wards [PDF]

, 2008
Ten hand-touch sites were screened weekly on two surgical wards over two consecutive six-month periods. The results were analysed using hygiene standards, which specify 1) an aerobic colony count (ACC) >2.5cfu/cm2, and 2) presence of coagulase-positive ...
Robertson, C., Dancer, S.J., White, L.F.
core   +4 more sources

Unmasking Methicillin-resistant Staphylococcus argenteus: pathogenic potential, diagnostic pitfalls and antibiotic resistance of MRSArg in Norway 2008–2019

Frontiers in Microbiology
BackgroundStaphylococcus argenteus is a coagulase-positive species within the Staphylococcus aureus complex that may carry the mecA gene, conferring methicillin resistance. Despite its clinical relevance, methicillin-resistant S.
Torunn Gresdal Rønning, Torunn Gresdal Rønning, Torunn Gresdal Rønning, Hege Enger, Hege Enger, Kyriakos Zaragkoulias, Christina Gabrielsen Ås, Christina Gabrielsen Ås, Christina Gabrielsen Ås   +8 more
doaj   +1 more source

Antimicrobial Resistance and Major Virulence Gene Detection in Methicillin Resistant Staphylococcus aureus in Humans and Livestock Animals of Assam: A North Eastern State of India

Journal of Pure and Applied Microbiology, 2023
Methicillin resistant Staphylococcus aureus (MRSA) is highly divergent antibiotic resistant bacteria earmarked as “High” in global pathogens’ priority list varying the severity and resistance geographically.
Naba Kumar Deka, Pratap Jyoti Handique, Probodh Borah, Pranita Konwar, Geetanjali Deka, Rijumani Das, Mridusmita Choudhury   +6 more
doaj   +1 more source

Bioenergetic Materials for Tissue Regeneration: Modulating Metabolism to Promote Cellular Anabolism

Advanced Science, EarlyView.
Bioenergetic materials (BEMs) modulate cellular metabolism to promote tissue regeneration. Their principal mechanisms of action include metabolic substrate supplementation, metabolic enzyme modulation, organelle transfer, electrical current regulation, redox homeostasis modulation, and oxygen tension modulation.
Yuchen He, Yuwen Wang, Jonathan F. Gong, Yiting Lei, Fei Jin, Weihong Zhu, Rocky S. Tuan, Zhong Alan Li   +7 more
wiley   +1 more source

Beyond Nature's Blueprint: Macrocyclic Peptides Containing Unnatural Amino Acids in Therapeutic Development

Angewandte Chemie, EarlyView.
Strategic incorporation of unnatural amino acids transforms macrocyclic peptides into drug‐like molecules capable of engaging challenging targets. These building blocks enhance stability, permeability, and bioavailability, accelerating the development of next‐generation peptide therapeutics.
Krishna K. Sharma, Komal Sharma, Anku Sharma, Kamya Rao, Rahul Jain, Brett VanVeller   +5 more
wiley   +2 more sources

Methicillin-resistant Staphylococcus lugdunensis in a neonatal intensive care unit: diagnostic challenges and emergence of multidrug-resistance

Frontiers in Medicine
BackgroundStaphylococcus lugdunensis is a species within the group of coagulase-negative staphylococci (CoNS), typically regarded as a commensal organism residing on human skin.
Marianne Hille Smith, Torunn Gresdal Rønning, Torunn Gresdal Rønning, Siren Irene Rettedal, Siren Irene Rettedal, Hege Enger, Iren Høyland Löhr, Iren Høyland Löhr, Jon Sundal, Anlaug Vatne, Heidi Syre, Christina Gabrielsen Ås, Christina Gabrielsen Ås   +12 more
doaj   +1 more source

High Levels of Methicillin-Resistant Staphylococcus aureus Carriage Among Healthcare Workers at a Teaching Hospital in Addis Ababa Ethiopia: First Evidence Using mecA Detection

Infection and Drug Resistance, 2022
Kassu Desta,1,2 Eleni Aklillu,3 Yirgu Gebrehiwot,4 Fikre Enquselassie5 ,† Daire Cantillon,6 Leena Al-Hassan,6 James R Price,6 Melanie J Newport,6 Gail Davey,5,6 Yimtubezenash Woldeamanuel1 1Department of Microbiology, Immunology, and Parasitology, School
Desta K, Aklillu E, Gebrehiwot Y, Enquselassie F, Cantillon D, Al-Hassan L, Price JR, Newport MJ, Davey G, Woldeamanuel Y   +9 more
doaj  

Porphyrin‐Based Porous Materials for Antibacterial Applications

Advanced Science, EarlyView.
Porphyrin‐based porous materials have excellent photophysical properties and tunable structures for high‐efficiency antibacterial therapy. This review comprehensively discusses the structural design strategies and synthetic pathways of the four main types of porphyrin‐based porous materials, summarizes their cross‐domain antimicrobial applications, and
Xiao‐Xue Liang, Xin Li, Ying Xiong, Xin Wang, Ying‐Wei Yang   +4 more
wiley   +1 more source

Pyomyositis: case series of 14 patients to study the significance of early diagnosis and management

Гений oртопедии, 2022
Introduction Pyomyositis denotes primary pyogenic infection of skeletal muscle. It is predominantly a disease of tropical countries. It usually involves the largest muscle groups around the pelvic girdle and lower extremities.
Pranav Gupta, Shipra Garg, Keerty Garg, Mohit Jindal, Varsha Gupta, Aseem Garg   +5 more
doaj   +1 more source