Results 61 to 70 of about 265,225 (395)

Discovery of Two Brominated Oxindole Alkaloids as Staphylococcal DNA Gyrase and Pyruvate Kinase Inhibitors via Inverse Virtual Screening

Microorganisms, 2020
In the present study, a small marine-derived natural products library was assessed for antibacterial potential. Among 36 isolated compounds, a number of bis-indole derivatives exhibited growth-inhibitory activity towards Gram-positive strains (Bacillus ...
Ahmed M. Sayed, Hani A. Alhadrami, Seham S. El-Hawary, Rabab Mohammed, Hossam M. Hassan, Mostafa E. Rateb, Usama Ramadan Abdelmohsen, Walid Bakeer   +7 more
doaj   +1 more source

Super Staph in the Community: Is It Evolving? [PDF]

, 2015
Staphylococcus aureus infections are a common cause of disease, particularly in colonized people. They frequently cause staph infections and are often dubbed “Super Staph” because they are virulent and multidrug resistant. Recently, a series of published
Gillen, Alan L., Walters, Rachel
core   +1 more source

Membrane Microdomain Disassembly Inhibits MRSA Antibiotic Resistance

Cell, 2017
Summary A number of bacterial cell processes are confined functional membrane microdomains (FMMs), structurally and functionally similar to lipid rafts of eukaryotic cells.
E. García-Fernández, Gudrun Koch, R. Wagner, Á. Fekete, S. Stengel, Johannes Schneider, Benjamin Mielich-Süss, S. Geibel, S. Markert, C. Stigloher, Daniel López   +10 more
semanticscholar   +1 more source

Multi‐Enzyme Mimetic Molybdenum Nitride Nanozymes Reshape Subgingival Microenvironment for Synergistic Periodontitis Therapy via ROS Regulation and Microbiome Remodeling

Advanced Science, EarlyView.
ABSTRACT Periodontitis, a chronic inflammatory disease initiated and sustained by plaque microorganisms and host immune response, remains an intractable oral disease and a leading cause of tooth loss worldwide. Traditional mechanical debridement and adjunctive antibiotic or antiseptic therapy often shows limited efficacy due to the complex anatomical ...
Weiyu Zhang, Zhongwei Yang, Yunfan Zhang, Longwei Wang, Xiaoyu Zhang, Jiahui Mao, Yizhi Dai, Yifan Yuan, Mingge Wang, Xin Yang, Xin Yu, Jing Liu, Chunying Chen   +12 more
wiley   +1 more source

Throat and rectal swabs may have an important role in MRSA screening of critically ill patients.

, 2008
OBJECTIVE: Methicillin-resistant Staphylococcus aureus (MRSA) is a major problem in intensive care units (ICU). International guidelines recommend screening patients for MRSA on admission, although consensus on sites required for optimum detection has ...
Batra, Rahul, Edgeworth, Jonathan, Eziefula, Alice C, Wyncoll, Duncan   +3 more
core   +1 more source

Enzymatic DNA Reaction Networks for Orchestrating Stimuli‐Dependent Temporal Molecular Pulse

Advanced Science, EarlyView.
We present an enzymatic DNA reaction network (EDRN) that encodes nucleic‐acid targets in time, converting inputs into a universal strand and then into programmable transient fluorescence pulses. With time‐color multiplexing, EDRN enables single‐tube high‐plex nucleic acid detection and shows strong agreement with clinical sequencing across 32 specimens.
Jiayu Yang, Yali Chang, Zibin Chu, Linghao Zhang, Tengfang Zhang, Dai Erhei, Xin Su, Zhe Yin   +7 more
wiley   +1 more source

Pattern and drug sensitivity of non-specific bacterial population in tuberculosis patients with multiple drug resistance

Туберкулез и болезни лёгких, 2019
The objective: to study the patterns of nonspecific bacterial population isolated in patients with multiple drug resistant tuberculosis in the city of Karaganda and assess its sensitivity to antimicrobial agents.Subjects and methods.
A. V. Lavrinenko, I. S. Аzizov, S. I. Kolesnichenko, M. T. Kozhamuratov, N. S. Tabriz, Zh. Mutaykhan   +5 more
doaj   +1 more source

Comparison of ferment sugars, produce hemolysis and measuring growth in methicillin-resistant and methicillin-sensitive Staphylococcus aureus isolates from inpatients and healthcare workers in Gorgan Hospitals, North of Iran [PDF]

, 2013
The mec A gene in Staphylococcus aureus leads to production of new penicillin-binding protein called PBP2a.This change may follow some changes in other phenotypes.
Amini, A., AsgharAyatollahi, A., Ghaemi, E.A., Kazemi, R., Koohsar, F., Kouhsari, E., Rahimi, S., Roustaei, M.   +7 more
core   +1 more source

Ultrasound‐Activated Bifunctional Piezoelectric Hydrogel Dressings Promote Infected Wound Healing via Regulating Angiogenesis and Lymphangiogenesis

Advanced Science, EarlyView.
This study developed a double‐network hydrogel with piezoelectric properties, exhibiting excellent antibacterial activity and promoting fibroblast migration, angiogenesis, and lymphangiogenesis through piezoelectric stimulation, thereby accelerating the healing of infected chronic wounds.
Xiang Li, Zhen Ding, Zhihua Liu, Hao Chen, Jianyang Shan, Yanxuan Shao, Yaling Yu, Gen Wen   +7 more
wiley   +1 more source

MRSA nasal colonization burden and risk of MRSA infection [PDF]

American Journal of Infection Control, 2013
Staphylococcus aureus nasal colonization burden has been identified as a risk factor for infection. This study evaluates methicillin-resistant S aureus (MRSA) nasal burden, as defined by the cycle threshold (Ct) and risk of subsequent infection.In a retrospective cohort study, United States veterans were classified into 3 MRSA nasal colonization groups:
Edward, Stenehjem, David, Rimland
openaire   +2 more sources