Results 41 to 50 of about 3,344,514 (294)
Structural insights into an engineered feruloyl esterase with improved MHET degrading properties
FEBS Letters, EarlyView.A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa +5 more
wiley +1 more source
Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system
FEBS Letters, EarlyView.Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley +1 more source
FEBS Letters, EarlyView.Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura +2 more
wiley +1 more source
Long-Term Adverse Events of Rituximab in Multiple Sclerosis Patients, Isfahan, Iran
International Journal of Preventive MedicineBackground: This study’s objective was to assess the adverse events (AEs) of rituximab (RTX) therapy in people with multiple sclerosis (pwMS). Methods: This observational study was conducted on clinical data of pwMS who visited an MS center in Iran from ...
Ali Rahimisadegh +6 more
doaj +1 more source
Pielęgniarstwo Neurologiczne i Neurochirurgiczne, 2015 Introduction. In order to achieve a learning success by a nurse during the pre- and post-graduate education, it is useful to apply the method of case studies using the International Classification for Nursing Practice (ICNP) or the traditional model of ...
Mariola Głowacka +1 more
doaj +1 more source
Degradation mechanism of the von Willebrand factor A2 domain by nattokinase
FEBS Letters, EarlyView.Nattokinase, a natto‐derived protease, exhibits potent antithrombotic effects. This study demonstrates that nattokinase directly cleaves the von Willebrand factor (vWF) A2 domain in vitro. Unlike the native regulator ADAMTS13, nattokinase degrades folded vWF independently of shear stress.
Ryuichi Hyakumoto +3 more
wiley +1 more source
Case presentation, Atypical imaging of MS (PP-11) [PDF]
Neurology Letters, 2023 A 36 year-old-lady, presented with numbness of left side of the face, followed by left-side weakness, upper limb more than the lower, leading to gait difficulty, associated with persistent pain in left knee joint, referred to a neurologist, so work up ...
Gholamali Yousefipour
doaj
Modulation of Homer1 EVH1 domain internal dynamics by putative autism‐associated mutations
FEBS Letters, EarlyView.The putative autism‐associated M65I and S97L variants of the EVH1 domain of the postsynaptic scaffold protein Homer1 do not exhibit substantial changes in their overall structure or partner binding. Both of them, but especially the M65I variant, show altered internal dynamics relative to the wild‐type domain on the μs‐ms timescale, indicated by the ...
Fanni Farkas +6 more
wiley +1 more source
Headache first manifestation of Multiple Sclerosis (PP-19) [PDF]
Neurology Letters, 2023 The importance of headaches in multiple sclerosis is largely neglected as focal neurological symptoms such as optic neuritis, paresthesia or weakness of organs has become the main focus of conce rn.
Fatemeh Abrishamchi
doaj
FEBS Letters, EarlyView.We present robust protocols for the preparation of supported lipid bilayers (SLBs) incorporating either Salmonella smooth LPS or outer membrane vesicles (OMVs). We use a combination of quartz crystal microbalance with dissipation (QCM‐D) and fluorescence microscopy to both characterize the SLBs of various compositions and to probe their interactions ...
Hudson P. Pace +6 more
wiley +1 more source