Results 51 to 60 of about 3,344,514 (294)
Biotechnology & Biotechnological Equipment, 2016 The establishment of a method for the removal of abundant proteins (APs) and enrichment of low-abundance proteins (LAPs) might contribute to further studies on the physiological functions of LAPs in animals and humans without the influence of APs.
Mingmei Liu +3 more
doaj +1 more source
Patient monitoring during treatment with natalizumab (ORP-24) [PDF]
Neurology Letters, 2023 Natalizumab (Tysabri), a recombinant humanized monoclonal antibody selective for α4- integrin, is indicated for CIS, RRMS, and active SPMS in adults.
Zohreh Abna
doaj
FEBS Letters, EarlyView.CT10 regulator of kinase (CRK) and CRK‐Like (CRKL) are signaling adaptors driving cell adhesion, motility, differentiation, and proliferation. SH2‐domain containing (SH) proteins are enriched in YXXP motifs which when phosphorylated create preferred binding sites for CRK family SH2 domains.
Phoebe M. Cousens +8 more
wiley +1 more source
Patient Preference and Adherence, 2023 Kathryn King,1 Serena McGuinness,1 Natalie Watson,1 Christine Norton,1 Trudie Chalder,2 Wladyslawa Czuber-Dochan1 1Florence Nightingale Faculty Nursing, Midwifery and Palliative Care, King’s College London, London, UK; 2Department of Psychological ...
King K +5 more
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The role of miR‐335‐5p in the redifferentiation of BRAF p.V600E thyroid cancers
Molecular Oncology, EarlyView.The BRAF p.V600E mutation promotes thyroid cancer dedifferentiation and radioiodine resistance. Using a network approach, we identified miR‐335‐5p as a key regulator of BRAF‐mutated thyroid tumors. Restoring miR‐335‐5p increased thyroid‐specific gene expression and iodine uptake in cells and organoids.
Valeria Pecce +11 more
wiley +1 more source
Fatigue and Affective Manifestations in Multiple Sclerosis—A Cluster Approach
Brain Sciences, 2019 Multiple sclerosis (MS) is a chronic autoimmune disease of the central nervous system, characterized by a high prevalence in young people, a drastic impact on the quality of life, and an important economic cost to society [...]
Samar S. Ayache, Moussa A. Chalah
doaj +1 more source
Salivary Metabolomics: From Diagnostic Biomarker Discovery to Investigating Biological Function
Metabolites, 2020 Metabolomic profiling of biofluids, e.g., urine, plasma, has generated vast and ever-increasing amounts of knowledge over the last few decades. Paradoxically, metabolomic analysis of saliva, the most readily-available human biofluid, has lagged.
Alexander Gardner +2 more
doaj +1 more source
Subtype‐specific enhancer RNAs define transcriptional regulators and prognosis in breast cancers
Molecular Oncology, EarlyView.This study employed machine learning methodologies to perform the subtype‐specific classification of RNA‐seq data sets, which are mapped on enhancers from TCGA‐derived breast cancer patients. Their integration with gene expression (referred to as ProxCReAM eRNAs) and chromatin accessibility profiles has the potential to identify lineage‐specific and ...
Aamena Y. Patel +6 more
wiley +1 more source
Evaluation of biocide effects of Aloysia gratissima (Gillies & Hook.) Tronc. essential oils
Biotechnologie, Agronomie, Société et EnvironnementDescription of the subject. Essential oils are volatile fractions produced through the special metabolism of plants. One significant biological application of essential oils in recent years has been their use as bioherbicides, due to their important ...
Caio Marins Rodrigues de Souza +8 more
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Molecular Oncology, EarlyView.Dimethyl fumarate (DMF) reduces growth of HPV‐positive cervical cancer spheroids and induces ferroptosis in cervical cancer cells via blocking SLC7A11/Glutathione (GSH) axis. Combination of subcytotoxic doses of DMF and cisplatin (CDDP) further suppresses spheroid growth and drives cell death in 2D culture models.
Carolina Punziano +6 more
wiley +1 more source