Results 11 to 20 of about 345,094 (162)

TGF-β1-overexpressing mesenchymal stem cells reciprocally regulate Th17/Treg cells by regulating the expression of IFN-γ

Open Life Sciences, 2021
Transforming growth factor (TGF)-β1 and mesenchymal stromal cells (MSCs) are two effective immunosuppressive agents for organ transplantation technology.
Li Ruixue, Wang Renyong, Zhong Shijie, Asghar Farhan, Li Tiehan, Zhu Lei, Zhu Hong   +6 more
doaj   +1 more source

Enhanced Proliferative and Osteogenic Potential of Periodontal Ligament Stromal Cells

Biomedicines, 2023
Cell-based therapies using periodontal ligament stromal cells (PDLSC) for periodontal regeneration may represent an alternative source for mesenchymal stromal cells (MSC) to MSC derived from bone marrow (MSC(M)) and adipose tissue (MSC(AT)).
Laura Alves, Vanessa Machado, João Botelho, José João Mendes, Joaquim M. S. Cabral, Cláudia L. da Silva, Marta S. Carvalho   +6 more
doaj   +1 more source

Single-cell RNA-seq of out-of-thaw mesenchymal stromal cells shows tissue-of-origin differences and inter-donor cell-cycle variations

Stem Cell Research & Therapy, 2021
Background Human Mesenchymal stromal cells (hMSCs) from various tissue sources are widely investigated in clinical trials. These MSCs are often administered to patients immediately after thawing the cryopreserved product (out-of-thaw), yet little is ...
Camila Medrano-Trochez, Paramita Chatterjee, Pallab Pradhan, Hazel Y. Stevens, Molly E. Ogle, Edward A. Botchwey, Joanne Kurtzberg, Carolyn Yeago, Greg Gibson, Krishnendu Roy   +9 more
doaj   +1 more source

Wound-Healing Effects of Mesenchymal Stromal Cell Secretome in the Cornea and the Role of Exosomes

Pharmaceutics, 2023
Mesenchymal stromal/stem cells (MSCs) and their secreted factors have been shown to have immunomodulatory and regenerative effects. In this study, we investigated human bone-marrow-derived MSC secretome (MSC-S) for the treatment of corneal epithelial ...
Seungwon An, Khandaker Anwar, Mohammadjavad Ashraf, Hyungjo Lee, Rebecca Jung, Raghuram Koganti, Mahmood Ghassemi, Ali R. Djalilian   +7 more
doaj   +1 more source

Increased Mesenchymal Stem Cell Functionalization in Three-Dimensional Manufacturing Settings for Enhanced Therapeutic Applications

Frontiers in Bioengineering and Biotechnology, 2021
Mesenchymal stem/stromal cell (MSC) exist within their in vivo niches as part of heterogeneous cell populations, exhibiting variable stemness potential and supportive functionalities.
Dimitrios Kouroupis, Dimitrios Kouroupis, Diego Correa, Diego Correa   +3 more
doaj   +1 more source

Cancer cell cannibalism and the SASP: Ripples in the murky waters of tumor dormancy

Molecular & Cellular Oncology, 2017
Relapse in cancer patients following an apparent cure and a prolonged latency period, known as tumor dormancy, remains an unrelenting clinical crisis.
Thomas J. Bartosh
doaj   +1 more source

Mesenchymal stem cells engineered to inhibit complement-mediated damage. [PDF]

PLoS ONE, 2013
Mesenchymal stem cells (MSC) preferentially migrate to damaged tissues and, due to their immunomodulatory and trophic properties, contribute to tissue repair.
Melisa A Soland, Mariana Bego, Evan Colletti, Esmail D Zanjani, Stephen St Jeor, Christopher D Porada, Graça Almeida-Porada   +6 more
doaj   +1 more source

The Carbonic Anhydrase IX inhibitor SLC-0111 as emerging agent against the mesenchymal stem cell-derived pro-survival effects on melanoma cells

Journal of Enzyme Inhibition and Medicinal Chemistry, 2020
Mesenchymal stem cells (MSC) take part to solid tumour-associated stroma and critically influence progression of malignancy. Our study represents a striking example of melanoma progression to a more malignant and resistant phenotype promoted by MSC and ...
Silvia Peppicelli, Elena Andreucci, Jessica Ruzzolini, Francesca Bianchini, Chiara Nediani, Claudiu T. Supuran, Lido Calorini   +6 more
doaj   +1 more source

The Effects of the Combination of Mesenchymal Stromal Cells and Nanofiber-Hydrogel Composite on Repair of the Contused Spinal Cord

Cells, 2022
A bone marrow-derived mesenchymal stromal cell (MSC) transplant and a bioengineered nanofiber-hydrogel composite (NHC) have been shown to stimulate nervous tissue repair in the contused spinal cord in rodent models.
Agnes E. Haggerty, Ines Maldonado-Lasunción, Yohshiro Nitobe, Kentaro Yamane, Megan M. Marlow, Hua You, Chi Zhang, Brian Cho, Xiaowei Li, Sashank Reddy, Hai-Quan Mao, Martin Oudega   +11 more
doaj   +1 more source

Ruptured inferior mesenteric artery aneurysm: a case report

Journal of Medicine in Scientific Research, 2019
Among visceral artery aneurysms, inferior mesenteric artery aneurysm is the rarest. Although most cases are of degenerative etiology, a small fraction of these cases are caused by autoimmune diseases.
Assem Mohamed Herzallah
doaj   +1 more source