Results 161 to 170 of about 6,450 (193)
Journal of Dental Research, 2011 Mutations in the transcription factors PAX9 and MSX1 cause selective tooth agenesis in humans. In tooth bud mesenchyme of mice, both proteins are required for the expression of Bmp4, which is the key signaling factor for progression to the next step of tooth development.
Y, Wang, H, Kong, G, Mues, R, D'Souza
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Association of MSX1 and TGFB3 with Nonsyndromic Clefting in Humans [PDF]
American Journal of Human Genetics, 1998 Nonsyndromic cleft lip with or without cleft palate (CL/P) and nonsyndromic cleft palate only (CPO) are common congenital anomalies with significant medical, psychological, social, and economic ramifications. Both CL/P and CPO are examples of complex genetic traits.
Andrew C Lidral +2 more
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MSX1—A Potential Marker for Uterus-Preserving Therapy of Endometrial Carcinomas [PDF]
International Journal of Molecular Sciences, 2020 Prognostic factors are of great interest in patients with endometrial cancer. One potential factor could be the protein MSX1, a transcription repressor, that has an inhibitory effect on the cell cycle. For this study, endometrioid endometrial carcinomas (n = 53), clear cell endometrial carcinomas (n = 6), endometrioid ovarian carcinomas (n = 19), and ...
C Kuhn, Elisa Schmoeckel, Sven Mahner
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Msx1 role in craniofacial bone morphogenesis
Bone, 2014The homeobox gene Msx1 encodes a transcription factor that is highly expressed during embryogenesis and postnatal development in bone. Mutations of the MSX1 gene in humans are associated with cleft palate and (or) tooth agenesis. A similar phenotype is observed in newborn mice invalidated for the Msx1 gene.
Ali Nassif +2 more
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Msx1 cooperates with Runx1 for inhibiting myoblast differentiation
Protein Expression and Purification, 2021Myogenesis is an important and complicated biological process, especially during the process of embryonic development. The homeoprotein Msx1 is a crucial transcriptional repressor of myogenesis and maintains myogenic precursor cells in an undifferentiated, proliferative state.
Guoqiang Zhou +2 more
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Modification of Msx1 by SUMO-1
Biochemical and Biophysical Research Communications, 2006The small ubiquitin-related modifier SUMO reversibly modifies many proteins, including promoter-specific transcription factors. Genetic studies in both humans and mice indicate that the Msx1 transcription factor is associated with specific disorders, including cleft palate.
Vandana A Gupta
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The role of MSX1 in tooth agenesis in Iranians
International Journal of Paediatric Dentistry, 2007Introduction. MSX1 gene has a critical role in craniofacial development, the aim of this case–control study is to test the hypothesis that MSX1 mutation contributes to congenital tooth agenesis in Iranians.Materials and methods. The study group consisted of 20 affected individuals with tooth agenesis of lower second premolars or upper lateral ...
Massoud, Seifi +2 more
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Studies on Pax9–Msx1 protein interactions
Archives of Oral Biology, 2005Pax9 belongs to the Pax family of transcriptional regulators that are defined by a highly conserved DNA-binding region, the paired domain. Drosophila, mouse and human genetics have shown that Pax proteins play multiple roles in tissue patterning and organogenesis by mediating their functions in a highly tissue-specific manner. Members of the Pax family,
Takuya, Ogawa +3 more
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Conditional alleles of Msx1 and Msx2
genesis, 2007AbstractThe msh‐related homeobox genes, Msx1 and Msx2, have a variety functions during murine organogenesis, Msx1 in the development of the palate and teeth, Msx2 in the skull, teeth, and skin. Msx1 mutants die perinatally. Compound Msx1‐2 mutants do not survive past late gestation.
Hualin, Fu +3 more
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Expression of MSX1 in Human Normal Pituitaries and Pituitary Adenomas
Endocrine Pathology, 2008Transcription factors play specific roles in the development and differentiation of normal pituitary tissues and pituitary adenoma. The transcription factor, muscle segment homeobox 1 (MSX1), which belongs to the homeobox gene family, binds the promoter region of the glycoprotein hormone alpha-subunit (SU) in TSH-producing cells in the mouse pituitary ...
Noboru Egashira +2 more
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