Results 1 to 10 of about 3,069 (190)

PAX9 in Cancer Development

International Journal of Molecular Sciences, 2022
Paired box 9 (PAX9) is a transcription factor of the PAX family functioning as both a transcriptional activator and repressor. Its functional roles in the embryonic development of various tissues and organs have been well studied. However, its roles and molecular mechanisms in cancer development are largely unknown.
Xiaoxin Chen, Heiko Peters, Ralf Kist
exaly   +4 more sources

Transcriptional analysis of the human PAX9 promoter [PDF]

Journal of Applied Oral Science, 2010
OBJECTIVES: PAX9 belongs to the Pax family of transcriptional factor genes. This gene is expressed in embryonic tissues such as somites, pharyngeal pouch endoderm, distal limb buds and neural crest-derived mesenchyme.
Carolina Vieira de Almeida, Simone Caixeta de Andrade, Cristiane Pereira Borges Saito, Liza Lima Ramenzoni, Sergio Roberto Peres Line   +4 more
doaj   +7 more sources

Four Novel PAX9 Variants and the PAX9-Related Non-Syndromic Tooth Agenesis Patterns

International Journal of Molecular Sciences, 2022
The purpose of this research was to investigate and identify PAX9 gene variants in four Chinese families with non-syndromic tooth agenesis. We identified pathogenic gene variants by whole-exome sequencing (WES) and Sanger sequencing and then studied the effects of these variants on function by bioinformatics analysis and in vitro experiments.
Miao Yu, Jinglei Zheng, Dong Han
exaly   +4 more sources

Novel PAX9 compound heterozygous variants in a Chinese family with non-syndromic oligodontia and genotype-phenotype analysis of PAX9 variants [PDF]

Journal of Applied Oral Science, 2023
Studies have reported that >91.9% of non-syndromic tooth agenesis cases are caused by seven pathogenic genes. Objective To report novel heterozygous PAX9 variants in a Chinese family with non-syndromic oligodontia and summarize the reported genotype ...
Jiabao REN, Ya ZHAO, Yunyun YUAN, Jing ZHANG, Yulin DING, Meikang LI, Yilin AN, Wenjing CHEN, Li ZHANG, Boyu LIU, Shushen ZHENG, Wenjing SHEN   +11 more
doaj   +5 more sources

PAX9 functions as a tumor suppressor gene for cervical cancer via modulating cell proliferation and apoptosis

Kaohsiung Journal of Medical Sciences, 2022
To investigate the effect of PAX9 on the progression of cervical cancer (CC). PAX9 expression was quantified in CC tissues and adjacent normal tissues, as well as human CC cell lines and human cervical epithelial cells (HCerEpiC).
Chun-Xiao Zhang
exaly   +2 more sources

Tooth agenesis patterns and variants in PAX9: A systematic review

Japanese Dental Science Review, 2023
Mutations in PAX9 are the most common genetic cause of tooth agenesis (TA). The aim of this study was to systematically review the profiles of the TA and PAX9 variants and establish their genotype-phenotype correlation.
Narin Intarak, Karn Tongchairati, Kittipat Termteerapornpimol, Soranun Chantarangsu, Thantrira Porntaveetus   +4 more
doaj   +3 more sources

A Combination of Variants in SEPTIN9 and MSX1 Genes Leads to the Formation of Orofacial Clefts. [PDF]

Genes Cells
Double‐depleted Xenopus embryos of xMSX1 and xSEPTIN9 exhibited orofacial clefts, and wild‐type but not variants in human MSX1 and human SEPTIN9 mRNAs could rescue the phenotype of morphants, indicating that variants in MSX1 and SEPTIN9, each individually tolerated, synergistically disrupt craniofacial morphogenesis to cause orofacial clefts.
Uuganbayar U, Manojlovic Z, Ito N, Yamaguchi R, Ninomiya H, Shimada IS, Yamada C, Feigelson D, Schulz G, Auslander A, Rakotoarison S, Magee W, Hashimoto Y, Kato Y.   +13 more
europepmc   +2 more sources

Unlocking predictive genetic factors with artificial intelligence: relationship between dental impaction and hypodontia evaluated via association-rule algorithms: a case–control study [PDF]

Saudi Dental Journal
Artificial intelligence (AI)-driven genetic analysis is crucial for the advancement of personalized dental treatments. Despite progress in genetic research, its clinical application remains limited.
Nora Alhazmi, Ali Alaqla, Bader Almuzzaini, Mohammed Aldrees, Ghaida Alnaqa, Farah Almasoud, Seena K. Thomas, Hala Alshamlan   +7 more
doaj   +2 more sources

Chromatin Remodeller BRD9 Orchestrates Odontoblastic Differentiation via Coordinating RUNX2-KLF4. [PDF]

Cell Prolif
During odontoblast lineage commitment, the chromatin remodeller BRD9 acts as a critical epigenetic coordinator, orchestrating the chromatin landscape to facilitate synergistic binding of key transcription factors RUNX2 and KLF4 to target loci for odontogenesis.
Zeng W, Lin Y, Gao Y, Huang D, Li Y, Ruan H, Yuan G, Liu H, Chen Z.   +8 more
europepmc   +2 more sources

Genetic architecture of craniofacial morphogenesis: roles of PAX3, PAX7, and PAX9 [PDF]

Frontiers in Cell and Developmental Biology
Craniofacial morphogenesis is a highly coordinated developmental process governed by complex genetic and molecular interactions. Among these, the PAX family of transcription factors plays a pivotal role in the regulation of neural crest specification ...
Kun Wang, Kun Wang, Kun Wang, Ning Li, Ning Li, Ning Li, Wanqi Liu, Wanqi Liu, Yong Gang Li, Yong Gang Li, Fu Ren, Fu Ren, Fu Ren   +12 more
doaj   +2 more sources