Kaohsiung Journal of Medical Sciences, 2022 To investigate the effect of PAX9 on the progression of cervical cancer (CC). PAX9 expression was quantified in CC tissues and adjacent normal tissues, as well as human CC cell lines and human cervical epithelial cells (HCerEpiC).
Chun-Xiao Zhang
exaly +2 more sources
Pax9’s Interaction With the Ectodysplasin Signaling Pathway During the Patterning of Dentition
Frontiers in Physiology, 2020 In these studies, we explored for the first time the molecular relationship between the paired-domain-containing transcription factor, Pax9, and the ectodysplasin (Eda) signaling pathway during mouse incisor formation.
Shihai Jia +2 more
exaly +3 more sources
The Evolution of Gene Sequencing Technologies: Unveiling Genetic Architecture of Nonsyndromic Orofacial Clefts. [PDF]
Genet Res (Camb)Nonsyndromic orofacial clefts (NSOC) are common congenital craniofacial developmental defects. Current evidence suggests that genetic factors, environmental exposures, and their interactions jointly contribute to the development of the disease. Owing to the high heritability of NSOC, identifying susceptibility genes and loci is a central focus of ...
Zhao H, Zhang S, Zhu H, Jia Z.
europepmc +2 more sources
Unlocking predictive genetic factors with artificial intelligence: relationship between dental impaction and hypodontia evaluated via association-rule algorithms: a case–control study [PDF]
Saudi Dental JournalArtificial intelligence (AI)-driven genetic analysis is crucial for the advancement of personalized dental treatments. Despite progress in genetic research, its clinical application remains limited.
Nora Alhazmi +7 more
doaj +2 more sources
Genetic architecture of craniofacial morphogenesis: roles of PAX3, PAX7, and PAX9 [PDF]
Frontiers in Cell and Developmental BiologyCraniofacial morphogenesis is a highly coordinated developmental process governed by complex genetic and molecular interactions. Among these, the PAX family of transcription factors plays a pivotal role in the regulation of neural crest specification ...
Kun Wang +12 more
doaj +2 more sources
TGF-β superfamily-induced transcriptional activation pathways establish the RAD52-dependent ALT machinery during malignant transformation of MPNSTs [PDF]
Scientific ReportsTo study telomere maintenance mechanism (TMM) activation during malignant transformation, we compared neurofibroma (NF) and malignant peripheral nerve sheath tumor (MPNST) in the same patient with type-1 neurofibromatosis (NF1), a total of 20 NF-MPNST ...
Eunji Choi +4 more
doaj +2 more sources
Association between PAX9 or MSX1 gene polymorphism and tooth agenesis risk: A meta-analysis [PDF]
Open Life SciencesZhong Xiaoyi +4 more
doaj +2 more sources
Novel PAX9 compound heterozygous variants in a Chinese family with non-syndromic oligodontia and genotype-phenotype analysis of PAX9 variants [PDF]
Journal of Applied Oral Science, 2023 Studies have reported that >91.9% of non-syndromic tooth agenesis cases are caused by seven pathogenic genes. Objective To report novel heterozygous PAX9 variants in a Chinese family with non-syndromic oligodontia and summarize the reported genotype ...
Jiabao REN +11 more
doaj +1 more source
Chitosan Hydrogel-Delivered ABE8e Corrects PAX9 Mutant in Dental Pulp Stem Cells
Gels, 2023 Hypodontia (dental agenesis) is a genetic disorder, and it has been identified that the mutation C175T in PAX9 could lead to hypodontia. Cas9 nickase (nCas9)-mediated homology-directed repair (HDR) and base editing were used for the correction of this ...
Bowen Liu +4 more
doaj +1 more source
Frontiers in Genetics, 2023 Background: Non-syndromic oligodontia is characterized by the absence of six or more permanent teeth, excluding third molars, and can have aesthetic, masticatory, and psychological consequences.
Jiabao Ren +12 more
doaj +1 more source