Results 21 to 30 of about 3,069 (190)

Detection of a rare AXIN2 variant in an Iranian family with hypodontia and oligodontia [PDF]

Journal of Dental Research, Dental Clinics, Dental Prospects, 2022
Background. Hypodontia, or the absence of one or more teeth during tooth formation, is a highly prevalent dental anomaly. Nevertheless, the main causes are still unknown.
Shiva Safari, Asghar Ebadifar, Hossien Najmabadi, Koorosh Kamali, Seyedeh Sedigheh Abedini, Mohammad Mousavi   +5 more
doaj   +1 more source

Pax9 is essential for granulopoiesis but dispensable for erythropoiesis in zebrafish

Biochemical and Biophysical Research Communications, 2021
Paired Box (Pax) gene family, a group of transcription regulators have been implicated in diverse physiological processes. However, their role during hematopoiesis which generate a plethora of blood cells remains largely unknown. Using a previously reported single cell transcriptomics data, we analyzed the expression of individual Pax family members in
Boryeong Pak, Chris E. Schmitt, Sera Oh, Jun-Dae Kim, Woosoung Choi, Orjin Han, Minjung Kim, Myoung-Jin Kim, Hyung-Jin Ham, Shanghyeon Kim, Tae-Lin Huh, Jae-Il Kim, Suk-Won Jin   +12 more
openaire   +2 more sources

Pax9’s Interaction With the Ectodysplasin Signaling Pathway During the Patterning of Dentition

Frontiers in Physiology, 2020
In these studies, we explored for the first time the molecular relationship between the paired-domain-containing transcription factor, Pax9, and the ectodysplasin (Eda) signaling pathway during mouse incisor formation.
Shihai Jia, Jeremie D. Oliver, Jeremie D. Oliver, Emma C. Turner, Maranda Renouard, Marianna Bei, J. T. Wright, Rena N. D’Souza, Rena N. D’Souza, Rena N. D’Souza   +9 more
doaj   +1 more source

Tooth dimensions in hypodontia with a known PAX9 mutation [PDF]

Archives of Oral Biology, 2009
Congenital absence of teeth is a complex condition affecting several parameters of oral development. This is the first study to measure tooth crown dimensions using image analysis in a family with hypodontia in whom the mutation has been identified, and compare them with a control group.Study models were obtained from 10 family members from three ...
Brook, AH, Elcock, C, Aggarwal, M, Lath, DL, Russell, JM, Patel, PI, Smith, RN   +6 more
openaire   +2 more sources

Characterization of PAX9 variant P20L identified in a Japanese family with tooth agenesis. [PDF]

PLoS ONE, 2017
Transcription factors PAX9 and MSX1 play crucial roles in the development of permanent teeth at the bud stage, and their loss-of-function variants have been associated with congenital tooth agenesis.
Akiko Murakami, Shinji Yasuhira, Hisayo Mayama, Hiroyuki Miura, Chihaya Maesawa, Kazuro Satoh   +5 more
doaj   +1 more source

Paired Box 9 (PAX9), the RNA polymerase II transcription factor, regulates human ribosome biogenesis and craniofacial development.

PLoS Genetics, 2020
Dysregulation of ribosome production can lead to a number of developmental disorders called ribosomopathies. Despite the ubiquitous requirement for these cellular machines used in protein synthesis, ribosomopathies manifest in a tissue-specific manner ...
Katherine I Farley-Barnes, Engin Deniz, Maya M Overton, Mustafa K Khokha, Susan J Baserga   +4 more
doaj   +1 more source

Contrasting evolutionary dynamics of the developmental regulator PAX9, among bats, with evidence for a novel post-transcriptional regulatory mechanism. [PDF]

PLoS ONE, 2013
Morphological evolution can be the result of natural selection favoring modification of developmental signaling pathways. However, little is known about the genetic basis of such phenotypic diversity.
Caleb D Phillips, Boyd Butler, John W Fondon, Hugo Mantilla-Meluk, Robert J Baker   +4 more
doaj   +1 more source

A developmental transcriptomic analysis of Pax1 and Pax9 in embryonic intervertebral disc development

Biology Open, 2017
Pax1 and Pax9 play redundant, synergistic functions in the patterning and differentiation of the sclerotomal cells that give rise to the vertebral bodies and intervertebral discs (IVD) of the axial skeleton. They are conserved in mice and humans, whereby
V. Sivakamasundari, Petra Kraus, Wenjie Sun, Xiaoming Hu, Siew Lan Lim, Shyam Prabhakar, Thomas Lufkin   +6 more
doaj   +1 more source

A Nonsyndromic Autosomal Dominant Oligodontia with A Novel Mutation of Pax9-A Clinical and Genetic Report [PDF]

Journal of Clinical and Diagnostic Research, 2015
Oligodontia is congenital absence of one or more teeth which has familial abnormality and attributable to various mutations or polymorphisms of genes often associated with malformative syndromes.
Umapathy Thimmegowda, Praveen Prasanna, Anantharaj Athimuthu, Prasanna Kumar Bhat, Yogish Puttashamachari   +4 more
doaj   +1 more source

Pax9 and Gbx2 Interact in the Pharyngeal Endoderm to Control Cardiovascular Development

Journal of Cardiovascular Development and Disease, 2020
The correct formation of the aortic arch arteries depends on a coordinated and regulated gene expression profile within the tissues of the pharyngeal arches.
Catherine A. Stothard, Silvia Mazzotta, Arjun Vyas, Jurgen E. Schneider, Timothy J. Mohun, Deborah J. Henderson, Helen M. Phillips, Simon D. Bamforth   +7 more
doaj   +1 more source