Results 41 to 50 of about 3,069 (190)

A novel nonsense mutation in PAX9 is associated with sporadic hypodontia [PDF]

Mutagenesis, 2011
The most important events during the regulation of tooth development were inductive interactions between the epithelial and mesenchymal tissues. The expression of Pax9 had been shown to specifically mark the mesenchymal regions at the prospective sites of all teeth prior to any morphological manifestations.
Junxia, Zhu, Xiang, Yang, Chenying, Zhang, Lihong, Ge, Shuguo, Zheng   +4 more
openaire   +2 more sources

A missense mutation in PAX9 in a family with distinct phenotype of oligodontia [PDF]

European Journal of Human Genetics, 2003
Mutations in PAX9 have been described for families in which inherited oligodontia characteristically involves permanent molars. Our study analysed one large family with dominantly inherited oligodontia clinically and genetically. In addition to permanent molars, some teeth were congenitally missing in the premolar, canine, and incisor regions ...
Laura, Lammi, Katri, Halonen, Sinikka, Pirinen, Irma, Thesleff, Sirpa, Arte, Pekka, Nieminen   +5 more
openaire   +2 more sources

Investigating a Tbx1 and Pax9 genetic interaction during cardiovascular development [PDF]

, 2015
PHD ThesisCongenital cardiovascular malformations (CCVM) are the most common type of birth defect in humans and can be life threatening for the newborn. 22q11 deletion syndrome (22q11DS) is one of the most common CCVM in humans, with patients presenting ...
Briones Leon, Jose Alberto
core   +1 more source

Pax1 and Pax9 synergistically regulate vertebral column development

The paralogous genes Pax1 and Pax9 constitute one group within the vertebrate Pax gene family. They encode closely related transcription factors and are expressed in similar patterns during mouse embryogenesis, suggesting that Pax1 and Pax9 act in ...
Maas R, Peters H, Imai K, Wilm B, Balling R, Sakai N   +5 more
core   +5 more sources

Molecular Evolution of the Primate Developmental Genes MSX1 and PAX9 [PDF]

Molecular Biology and Evolution, 2005
In primates, the craniofacial skeleton and the dentition are marked by high levels of interspecific variation. Despite this, there are few comparative species studies conducted at the molecular level to investigate this functional diversity. We have determined nucleotide sequences of MSX1 and PAX9, two developmental genes, in a sample of 27 diverse ...
George H, Perry, Brian C, Verrelli, Anne C, Stone   +2 more
openaire   +2 more sources

Ovarian Cancer: Epidemiology, Disease Mechanisms, New Diagnosis and Treatment Strategies, and Research Directions

iNew Medicine, EarlyView.
ABSTRACT Ovarian cancer (OC) continues to be the deadliest gynecological malignancy and a significant cause of cancer‐related mortality among women worldwide. Standard treatment strategies typically entail platinum‐based chemotherapy in conjunction with cytoreductive surgery.
Zunera Khalid, Weirong Fan, Farah Nazir, Yixiang Xing, Tengchuan Jin   +4 more
wiley   +1 more source

Expression of Pax9 in zebrafish ESQE and phenotypes of Pax9 knockdown zebrafish at 7dpf.

, 2015
(A) Normal zebrafish (Lateral view). (B) Pax9 knockdown fish with malformation of the lower jaw (Lateral view). (C) Alcian blue staining shows the orofacial cartilage of normal zebrafish (lateral view).
Xiaoxin Chen (88807), Hao Chen (5190), Andrea Beasley (832732), Yuhui Hu (7203)   +3 more
core   +1 more source

Reviewing the benefits and clinical outcomes of oral fibroblasts over mesenchymal stem cells for repairing periodontal defects during or after orthodontic tooth movement

Periodontology 2000, EarlyView.
Abstract Orthodontic therapy applies forces to teeth, causing an inflammatory reaction in the periodontal ligament. This is repaired by remodeling of the periodontium, allowing tooth displacement. Although orthodontic therapy is mostly initiated during childhood and adolescence, the number of adults seeking this treatment is increasing as our society's
Ludovica Parisi, Eleni Mavrogonatou, Anton Sculean, Dimitris Kletsas, Martin Degen   +4 more
wiley   +1 more source

Genes Linked with Orthodontic Issues and the Knowledge Gaps in This Association

Philippine Journal of Obstetrics and Gynecology, 2023
Orthodontics is the study of malpositioned teeth and jaws. Some commonly found orthodontic issues are malocclusions, mandibular prognathism, retrognathism, and facial asymmetry. These issues are associated with several genetic factors.
Abdulaziz Mohammed Alshahrani
doaj   +1 more source

From Association to Mechanism: Regulatory Annotation and Pathway Mapping of Genes Surrounding Breast Cancer Risk Variants

Computational and Systems Oncology, Volume 6, Issue 1, December 2026.
ABSTRACT Inherited factors account for a large share of breast cancer susceptibility, yet the biological consequences of most risk variants are still poorly understood. To address this gap, we studied 175 breast cancer risk variants confirmed by genome‐wide association studies and gathered the genes that lie near them.
Sultana Jannat, Trina Mitra, Nafisa Nawar Fariha, Tasmia Tabassum, Kulsuma Bahar Bethi, Synchita Majumder Kaya, Md. Arif Hossen, Md. Saad Hossain, Jobaier Ibne Deen, Mohammed Emon, Laila Khaleda, Md. Hridoy Ahmed   +11 more
wiley   +1 more source