Results 41 to 50 of about 4,591 (213)

Whole exome sequencing in an Italian family with isolated maxillary canine agenesis and canine eruption anomalies [PDF]

, 2018
Objective: The aim of this study was the clinical and molecular characterization of a family segregating a trait consisting of a phenotype specifically involving the maxillary canines, including agenesis, impaction and ectopic eruption, characterized by ...
Barbato, Ersilia, Caputo, Viviana, Ciolfi, Andrea, Di Giorgio, Roberto, Genovesi, Maria Luce, Giovannetti, Agnese, Guarnieri, Rosanna, Magliozzi, Maria Rosa, Paolacci, Stefano, Pizzi, Simone, Pizzuti, Antonio, Tartaglia, Marco, Traversa, Alice   +12 more
core   +1 more source

Six2 regulates Pax9 expression, palatogenesis and craniofacial bone formation

Developmental Biology, 2020
In this study, we investigated the role of the transcription factor Six2 in palate development. Six2 was selected using the SysFACE tool to predict genes from the 2p21 locus, a region associated with clefting in humans by GWAS, that are likely to be involved in palatogenesis.
Yan Yan, Sweat, Mason, Sweat, Maurisa, Mansaray, Huojun, Cao, Steven, Eliason, Waisu L, Adeyemo, Lord J J, Gowans, Mekonen A, Eshete, Deepti, Anand, Camille, Chalkley, Irfan, Saadi, Salil A, Lachke, Azeez, Butali, Brad A, Amendt   +13 more
openaire   +2 more sources

The formation of endoderm-derived taste sensory organs requires a Pax9-dependent expansion of embryonic taste bud progenitor cells.

PLoS Genetics, 2014
In mammals, taste buds develop in different regions of the oral cavity. Small epithelial protrusions form fungiform papillae on the ectoderm-derived dorsum of the tongue and contain one or few taste buds, while taste buds in the soft palate develop ...
Ralf Kist, Michelle Watson, Moira Crosier, Max Robinson, Jennifer Fuchs, Julia Reichelt, Heiko Peters   +6 more
doaj   +1 more source

Molecular and Genetic Basis of Non-Syndromic Tooth Agenesis

Česká Stomatologie a Praktické Zubní Lékařství, 2015
Background: Tooth agenesis represents the most common anomaly of dental development, which according to Online Mendelian Inheritance in Man (OMIM) database, affects approximately 20% of the population.
L. Kramerová, P. Krejčí, E. Míšová, A. Ševecová   +3 more
doaj   +1 more source

A review on non-syndromic tooth agenesis associated with PAX9 mutations

Japanese Dental Science Review, 2018
Summary: Tooth agenesis in the reduction of tooth number which includes hypodontia, oligodontia and anodontia is caused by disturbances and gene mutations that occur during odontogenesis.
Nurul Hasyiqin Fauzi, Yunita Dewi Ardini, Zarina Zainuddin, Widya Lestari   +3 more
doaj   +1 more source

Familial aggregation of maxillary lateral incisor agenesis [PDF]

, 2010
In spite of recent developments, data regarding the genes responsible for the less severe forms of hypodontia are still scarce and controversial. This study addressed the hypothesis that agenesis of maxillary lateral incisors (MLIA) is a distinct type of
A. Sousa, Aasheim B, C. Lemos, Cantor RM, Grahnén H, P. Maciel, Proffit WR, Rolling S, T. Pinho, Thilander B, Woolf CM   +10 more
core   +1 more source

Characterization of Zebrafish Pax1b and Pax9 in Fin Bud Development [PDF]

BioMed Research International, 2014
Both Pax1 and Pax9 belong to the important paired box gene family (PAX), which mainly participates in animal development and sclerotome differentiation. To date, the precise molecular mechanism and related signaling pathway of Pax1 remain unclear. In our study, microinjection of morpholino- (MO-) modified antisense oligonucleotides againstpax1binduced ...
Chen, Xuemei, Huang, Huizhe, Wang, Hua, Guo, Fengjin, Du, Xiaogang, Ma, Linqiang, Zhao, Liang, Pan, Zhuma, Gui, Haibo, Yuan, Taixian, Liu, Xin, Song, Lin, Wang, Yiquan, He, Junling, Lei, Han, Gao, Rui   +15 more
openaire   +2 more sources

Exclusion of PAX9 and MSX1 mutation in six families affected by tooth agenesis. A genetic study and literature review [PDF]

, 2014
Objectives: In the present study, it is described the phenotypical analysis and the mutational screening, for genes PAX9 and MSX1, of six families affected by severe forms of tooth agenesis associated with other dental anomalies and systemic entities ...
Arte, Sirpa, Carvalho Lobato, P., Manzanares Céspedes, María Cristina, Nieminen, Pekka, Tallón Walton, Victòria, Valdivia Gandur, Ivan   +5 more
core   +1 more source

Vascular endothelium plays a key role in directing pulmonary epithelial cell differentiation. [PDF]

, 2017
The vascular endothelium is critical for induction of appropriate lineage differentiation in organogenesis. In this study, we report that dysfunctional pulmonary endothelium, resulting from the loss of matrix Gla protein (MGP), causes ectopic hepatic ...
Blazquez-Medela, Ana M, Boström, Kristina I, Fogelman, Alan M, Guihard, Pierre J, Jumabay, Medet, Spencer, Melissa J, Tontonoz, Peter, Wu, Xiuju, Yao, Jiayi, Yao, Yucheng   +9 more
core   +2 more sources

Pax proteins in embryogenesis and their role in nervous system development [PDF]

, 2013
The mammalian Pax genes encode a family of transcription factors, which play important roles in embryonic development and organogenesis. During the central nervous system development Pax genes have substantial roles in neural differentiation and regional
Arend, Andres, Aunapuu, Marina, Namm, Aimar   +2 more
core   +3 more sources