Results 31 to 40 of about 2,193 (172)

PAX9 polymorphism and susceptibility to sporadic non-syndromic severe anodontia: a case-control study in southwest China

Journal of Applied Oral Science, 2013
Our research aimed to look into the clinical traits and genetic mutations in sporadic non-syndromic anodontia and to gain insight into the role of mutations of PAX9, MSX1, AXIN2 and EDA in anodontia phenotypes, especially for the PAX9.
Jing WANG, Yuanzhi XU, Jing CHEN, Feiyu WANG, Renhuan HUANG, Songtao WU, Linjing SHU, Jingyi QIU, Zhi YANG, Junjie XUE, Raorao WANG, Jilin ZHAO, Wenli LAI   +12 more
doaj   +1 more source

Characterization of Zebrafish Pax1b and Pax9 in Fin Bud Development [PDF]

BioMed Research International, 2014
Both Pax1 and Pax9 belong to the important paired box gene family (PAX), which mainly participates in animal development and sclerotome differentiation. To date, the precise molecular mechanism and related signaling pathway of Pax1 remain unclear. In our study, microinjection of morpholino- (MO-) modified antisense oligonucleotides againstpax1binduced ...
Chen, Xuemei, Huang, Huizhe, Wang, Hua, Guo, Fengjin, Du, Xiaogang, Ma, Linqiang, Zhao, Liang, Pan, Zhuma, Gui, Haibo, Yuan, Taixian, Liu, Xin, Song, Lin, Wang, Yiquan, He, Junling, Lei, Han, Gao, Rui   +15 more
openaire   +2 more sources

A review on non-syndromic tooth agenesis associated with PAX9 mutations

Japanese Dental Science Review, 2018
Summary: Tooth agenesis in the reduction of tooth number which includes hypodontia, oligodontia and anodontia is caused by disturbances and gene mutations that occur during odontogenesis.
Nurul Hasyiqin Fauzi, Yunita Dewi Ardini, Zarina Zainuddin, Widya Lestari   +3 more
doaj   +1 more source

A missense mutation in PAX9 in a family with distinct phenotype of oligodontia [PDF]

European Journal of Human Genetics, 2003
Mutations in PAX9 have been described for families in which inherited oligodontia characteristically involves permanent molars. Our study analysed one large family with dominantly inherited oligodontia clinically and genetically. In addition to permanent molars, some teeth were congenitally missing in the premolar, canine, and incisor regions ...
Laura, Lammi, Katri, Halonen, Sinikka, Pirinen, Irma, Thesleff, Sirpa, Arte, Pekka, Nieminen   +5 more
openaire   +2 more sources

Molecular Evolution of the Primate Developmental Genes MSX1 and PAX9 [PDF]

Molecular Biology and Evolution, 2005
In primates, the craniofacial skeleton and the dentition are marked by high levels of interspecific variation. Despite this, there are few comparative species studies conducted at the molecular level to investigate this functional diversity. We have determined nucleotide sequences of MSX1 and PAX9, two developmental genes, in a sample of 27 diverse ...
George H, Perry, Brian C, Verrelli, Anne C, Stone   +2 more
openaire   +2 more sources

Ovarian Cancer: Epidemiology, Disease Mechanisms, New Diagnosis and Treatment Strategies, and Research Directions

iNew Medicine, EarlyView.
ABSTRACT Ovarian cancer (OC) continues to be the deadliest gynecological malignancy and a significant cause of cancer‐related mortality among women worldwide. Standard treatment strategies typically entail platinum‐based chemotherapy in conjunction with cytoreductive surgery.
Zunera Khalid, Weirong Fan, Farah Nazir, Yixiang Xing, Tengchuan Jin   +4 more
wiley   +1 more source

Chromatin Remodeller BRD9 Orchestrates Odontoblastic Differentiation via Coordinating RUNX2‐KLF4

Cell Proliferation, EarlyView.
During odontoblast lineage commitment, the chromatin remodeller BRD9 acts as a critical epigenetic coordinator, orchestrating the chromatin landscape to facilitate synergistic binding of key transcription factors RUNX2 and KLF4 to target loci for odontogenesis.
Wenrui Zeng, Yuxiu Lin, Yongyan Gao, Delan Huang, Yuanyuan Li, Honglei Ruan, Guohua Yuan, Huan Liu, Zhi Chen   +8 more
wiley   +1 more source

Reviewing the benefits and clinical outcomes of oral fibroblasts over mesenchymal stem cells for repairing periodontal defects during or after orthodontic tooth movement

Periodontology 2000, EarlyView.
Abstract Orthodontic therapy applies forces to teeth, causing an inflammatory reaction in the periodontal ligament. This is repaired by remodeling of the periodontium, allowing tooth displacement. Although orthodontic therapy is mostly initiated during childhood and adolescence, the number of adults seeking this treatment is increasing as our society's
Ludovica Parisi, Eleni Mavrogonatou, Anton Sculean, Dimitris Kletsas, Martin Degen   +4 more
wiley   +1 more source

Genes Linked with Orthodontic Issues and the Knowledge Gaps in This Association

Philippine Journal of Obstetrics and Gynecology, 2023
Orthodontics is the study of malpositioned teeth and jaws. Some commonly found orthodontic issues are malocclusions, mandibular prognathism, retrognathism, and facial asymmetry. These issues are associated with several genetic factors.
Abdulaziz Mohammed Alshahrani
doaj   +1 more source

From Association to Mechanism: Regulatory Annotation and Pathway Mapping of Genes Surrounding Breast Cancer Risk Variants

Computational and Systems Oncology, Volume 6, Issue 1, December 2026.
ABSTRACT Inherited factors account for a large share of breast cancer susceptibility, yet the biological consequences of most risk variants are still poorly understood. To address this gap, we studied 175 breast cancer risk variants confirmed by genome‐wide association studies and gathered the genes that lie near them.
Sultana Jannat, Trina Mitra, Nafisa Nawar Fariha, Tasmia Tabassum, Kulsuma Bahar Bethi, Synchita Majumder Kaya, Md. Arif Hossen, Md. Saad Hossain, Jobaier Ibne Deen, Mohammed Emon, Laila Khaleda, Md. Hridoy Ahmed   +11 more
wiley   +1 more source