Results 1 to 10 of about 5,369 (125)

MSX1 variant causes nonsyndromic tooth agenesis in a Japanese patient [PDF]

Human Genome Variation
MSX1 variants are associated with autosomal dominant craniofacial developmental anomalies, including congenital tooth agenesis. Here, whole-exome sequencing in a Japanese patient with congenital tooth agenesis identified a novel de novo heterozygous ...
Yasuto Sano, Michiyo Ando, Reiko Tokuyama-Toda, Akiko Ota, Junichiro Machida, Kazuhito Satomura, Mitsuo Goto, Yoshihito Tokita   +7 more
doaj   +2 more sources

Identification of tumor-promoting functions of the Homeobox family transcription factor MSX1 in cervical cancer [PDF]

Cell Death Discovery
Cervical cancer (CC) remains a leading cause of cancer-related mortality among women, particularly in underdeveloped or developing countries lacking adequate screening programs.
Paulina Brücker, Svenja Horn, Shaishavi Jansari, Marianna Kombou, Simon Eppich, Udo Jeschke, Samy Hakroush, Stefan Küffer, Sonja Fritzsche, Florian Wegwitz, Julia Gallwas   +10 more
doaj   +2 more sources

Homeoprotein Msx1-PIASy Interaction Inhibits Angiogenesis

Cells, 2020
Previously, we demonstrated that the homeoprotein Msx1 interaction with p53 inhibited tumor growth by inducing apoptosis. However, Msx1 can exert its tumor suppressive effect through the inhibition of angiogenesis since growth of the tumor relies on ...
Myung Jin Son, Seung Bae Rho, Mijung Oh
exaly   +3 more sources

Current insights on the genetics and mechanisms of MSX1-associated cleft palate [PDF]

Frontiers in Dental Medicine
Cleft palate, a common congenital anomaly, is characterized by a failure of the palatal shelves to fuse during embryogenesis, resulting in an opening between the oral and nasal cavities.
AC. Myo, R. Raju, J. O. Piña, P. Chattaraj, M. Furukawa   +4 more
doaj   +2 more sources

Acetylation-triggered degradation of MSX1 impairs palatal development [PDF]

Cell Death Discovery
Cleft palate, a prevalent congenital disorder, arises from dysregulated embryonic palatal fusion, but the posttranslational modifications (PTMs) driving this process remain poorly understood.
Li Meng, Jiawen You, Zhongyin Zhang, Yucheng Jiang, Yulan Liu, Mingliang Zhou, Junqing Ma, Xinquan Jiang   +7 more
doaj   +2 more sources

Wnt3a promotes in situ dentin formation through NKD1-MSX1 axis-mediated odontogenic differentiation of dental pulp stem cells [PDF]

International Journal of Oral Science
The functional regeneration of the dentin-pulp complex is pivotal for tooth preservation, yet the molecular mechanisms governing odontoblast differentiation remain poorly understood.
Haoran Du, Qiong Li, Chenchen Zhou, Junji Xu, Kang Gao, Zixiao Li, Yifan Xu, Ousheng Liu, Bing Li, Jianguang Xu, Jingsong Wang, Hideaki Kagami, Xianqi Li, Su Chen, Jian Zhou   +14 more
doaj   +2 more sources

Correction to "The Activation of cGAS-STING Pathway Causes Abnormal Uterine Receptivity in Aged Mice". [PDF]

Aging Cell
Aging Cell, Volume 25, Issue 5, May 2026.
europepmc   +2 more sources

Homeobox protein MSX-1 restricts hepatitis B virus by promoting ubiquitin-independent proteasomal degradation of HBx protein. [PDF]

PLoS Pathogens
Hepatitis B virus (HBV) X protein (HBx) is a key factor for regulating viral transcription and replication. We recently characterized homeobox protein MSX-1 (MSX1) as a host restriction factor that inhibits HBV gene expression and genome replication by ...
Qian Qiu, Zihan He, Jing Liu, Huijun Xu, Jinyu Wang, Nannan Liu, Ning Kang, Shaokun Pan, Weien Yu, Zixiang Gao, Shimei Zhang, Yang Yang, Qiang Deng, Youhua Xie, Jiming Zhang, Zhongliang Shen   +15 more
doaj   +2 more sources

PRMT1-methylated MSX1 phase separates to control palate development [PDF]

Nature Communications
Little is known about the regulation and function of phase separation in craniofacial developmental disorders. MSX1 mutations are associated with human cleft palate, the most common craniofacial birth defect. Here, we show that MSX1 phase separation is a
Li Meng, Yucheng Jiang, Jiawen You, Yatao Chen, Shuyu Guo, Liming Chen, Junqing Ma   +6 more
doaj   +2 more sources

p75NTR Promotes Circadian-Driven Mineralization During Tooth Development via CK2/PER2 Pathway. [PDF]

Cell Prolif
The diagram illustrates how the circadian rhythm regulates the p75NTR‐CK2‐PER2 axis, driving rhythmic biomineralisation during tooth development. ABSTRACT Circadian rhythm is an essential biological process that synchronises physiological activities with environmental light/dark cycles.
Zhao M, Yuan H, Wang D, Li M, Xie B, Zou X, Lu M, Qiu Y, Song J.   +8 more
europepmc   +2 more sources