PLoS ONE, 2014 Since MSX1 and PAX9 are linked to the pathogenesis of nonsyndromic tooth agenesis, we performed detailed mutational analysis of these two genes sampled from Japanese patients.
Seishi Yamaguchi +11 more
doaj +2 more sources
Identification of nuclear localization signals in the human homeoprotein MSX1 [PDF]
Biochemistry and Cell Biology, 2018 MSX1 is one of the homeoproteins with the homeodomain (HD) sequence, which regulates proliferation and differentiation of mesenchymal cells. In this study, we investigated the nuclear localization signal (NLS) in the MSX1 HD by deletion and amino acid substitution analyses. The web-based tool NLStradamus predicted 2 putative basic motifs in the N- and
Shibata, Akio +8 more
openaire +4 more sources
Novel MSX1 Gene Variants in Chinese Children with Non-Syndromic Tooth Agenesis: A Clinical and Genetic Analysis [PDF]
ChildrenBackground: Tooth agenesis is the most frequently occurring genetic developmental anomaly in clinical dentistry. The MSX1 gene, essential for tooth development, has been associated with non-syndromic tooth agenesis. This study aims to identify novel MSX1
Tingting Ding, Haochen Liu, Guoxia Yu
doaj +2 more sources
MSX1 and TGFB3 Contribute to Clefting in South America
Journal of Dental Research, 2003 MSX1 and TGFB3 have been proposed as genes in which mutations may contribute to non-syndromic forms of oral clefts; however, an interaction between these genes has not been described. The present study attempts to detect transmission distortion of MSX1 and TGFB3 in 217 South American children from their respective mothers.
A R, Vieira +5 more
openaire +3 more sources
PIAS1 confers DNA-binding specificity on the Msx1 homeoprotein [PDF]
Genes & Development, 2006 The mechanisms by which homeoproteins bind selectively to target genes in vivo have long remained unresolved. Here we report that PIAS1 confers DNA-binding specificity on the Msx1 homeoprotein by regulating its subnuclear localization and proximity to target genes. We demonstrate that the interaction of Msx1 with PIAS1, but not its
Hansol, Lee +7 more
openaire +3 more sources
Role of MSX1 in Osteogenic Differentiation of Human Dental Pulp Stem Cells [PDF]
Stem Cells International, 2016 Msh homeobox 1 (MSX1) encodes a transcription factor implicated in embryonic development of limbs and craniofacial tissues including bone and teeth. Although MSX1 regulates osteoblast differentiation in the cranial bone of young animal, little is known ...
Noriko Goto +9 more
doaj +2 more sources
Novel MSX1 variants identified in families with nonsyndromic oligodontia [PDF]
International Journal of Oral Science, 2021 The goal of this study was to identify MSX1 gene variants in multiple Chinese families with nonsyndromic oligodontia and analyse the functional influence of these variants. Whole-exome sequencing (WES) and Sanger sequencing were performed to identify the
Jinglei Zheng +6 more
doaj +3 more sources
Association of MSX1 gene polymorphisms and maxillary lateral incisor agenesis in Non-syndromic cleft lip and/or palate individuals [PDF]
Journal of Oral Biology and Craniofacial ResearchBackground: To investigate the association between MSX1 gene polymorphisms and maxillary lateral incisor agenesis with and without Non Syndromic Cleft lip and palate (NSCL/P) in a South Indian population.
Dhanyashri Kamalakannan +4 more
doaj +2 more sources
Association between PAX9 or MSX1 gene polymorphism and tooth agenesis risk: A meta-analysis [PDF]
Open Life SciencesZhong Xiaoyi +4 more
doaj +2 more sources
MSX1-expression during the different phases in healthy human endometrium [PDF]
, 2023 Purpose The human endometrium consists of different layers (basalis and functionalis) and undergoes different phases throughout the menstrual cycle.
Schmoeckel, Elisa +15 more
core +1 more source