Results 21 to 30 of about 5,422 (162)

The Role of MSX1 in Human Tooth Agenesis [PDF]

Journal of Dental Research, 2002
MSX1 has a critical role in craniofacial development, as indicated by expression assays and transgenic mouse phenotypes. Previously, MSX1 mutations have been identified in three families with autosomal-dominant tooth agenesis. To test the hypothesis that MSX1 mutations are a common cause of congenital tooth agenesis, we screened 92 affected individuals,
A C, Lidral, B C, Reising
openaire   +2 more sources

Detection of a rare AXIN2 variant in an Iranian family with hypodontia and oligodontia [PDF]

Journal of Dental Research, Dental Clinics, Dental Prospects, 2022
Background. Hypodontia, or the absence of one or more teeth during tooth formation, is a highly prevalent dental anomaly. Nevertheless, the main causes are still unknown.
Shiva Safari, Asghar Ebadifar, Hossien Najmabadi, Koorosh Kamali, Seyedeh Sedigheh Abedini, Mohammad Mousavi   +5 more
doaj   +1 more source

70759 Jaw-specific control of Msx1-dependent odontogenesis by Dkk2 and Sostdc1

Journal of Clinical and Translational Science, 2021
IMPACT: Our proposed jaw-specific control mechanism of tooth development is expected to address the site-specific prevalence of tooth agenesis in humans. OBJECTIVES/GOALS: To determine the molecular mechanisms that control jaw-specific tooth development.
Hyuk-Jae Edward Kwon
doaj   +1 more source

p75NTR Promotes Circadian-Driven Mineralization During Tooth Development via CK2/PER2 Pathway. [PDF]

Cell Prolif
The diagram illustrates how the circadian rhythm regulates the p75NTR‐CK2‐PER2 axis, driving rhythmic biomineralisation during tooth development. ABSTRACT Circadian rhythm is an essential biological process that synchronises physiological activities with environmental light/dark cycles.
Zhao M, Yuan H, Wang D, Li M, Xie B, Zou X, Lu M, Qiu Y, Song J.   +8 more
europepmc   +2 more sources

Emerin anchors Msx1 and its protein partners at the nuclear periphery to inhibit myogenesis

Cell & Bioscience, 2019
Background Previous studies have shown that in myogenic precursors, the homeoprotein Msx1 and its protein partners, histone methyltransferases and repressive histone marks, tend to be enriched on target myogenic regulatory genes at the nuclear periphery.
Zhangjing Ma, Huiyuan Shi, Yi Shen, Huixia Li, Yu Yang, Jiange Yang, Hui Zhao, Gang Wang, Jingqiang Wang   +8 more
doaj   +1 more source

Expression of MSX1, HOXA11 and TP53I3 in the endometrium associated with the onset of pregnancy after repeated failed IVF attempts in patients with tubo-peritoneal factor infertility

Гинекология, 2020
Relevance. The success of the in vitro fertilisation (IVF) program, among other factors, depends on the readiness of the endometrium to accept the embryo.
Ekaterina A. Knyazeva, Maria V. Kuznetsova, Olga V. Burmenskaya, Andrey E. Donnikov, Elena A. Kalinina   +4 more
doaj   +1 more source

An aberrant splice acceptor site due to a novel intronic nucleotide substitution in MSX1 gene is the cause of congenital tooth agenesis in a Japanese family. [PDF]

PLoS ONE, 2015
Congenital tooth agenesis is caused by mutations in the MSX1, PAX9, WNT10A, or AXIN2 genes. Here, we report a Japanese family with nonsyndromic tooth agenesis caused by a novel nucleotide substitution in the intronic region between exons 1 and 2 of the ...
Tadashi Tatematsu, Masashi Kimura, Mitsuko Nakashima, Junichiro Machida, Seishi Yamaguchi, Akio Shibata, Hiroki Goto, Atsuo Nakayama, Yujiro Higashi, Hitoshi Miyachi, Kazuo Shimozato, Naomichi Matsumoto, Yoshihito Tokita   +12 more
doaj   +1 more source

A Nonsense Mutation in MSX1 Causes Witkop Syndrome [PDF]

The American Journal of Human Genetics, 2001
Witkop syndrome, also known as tooth and nail syndrome (TNS), is a rare autosomal dominant disorder. Affected individuals have nail dysplasia and several congenitally missing teeth. To identify the gene responsible for TNS, we used candidate-gene linkage analysis in a three-generation family affected by the disorder.
Jumlongras, Dolrudee, Bei, Marianna, Stimson, Jean M., Wang, Wen-Fang, DePalma, Steven R., Seidman, Christine E., Felbor, Ute, Maas, Richard, Seidman, Jonathan G., Olsen, Bjorn R.   +9 more
openaire   +2 more sources

Msx1 haploinsufficiency modifies the Pax9-deficient cardiovascular phenotype [PDF]

BMC Developmental Biology, 2021
Abstract Background Successful embryogenesis relies on the coordinated interaction between genes and tissues. The transcription factors Pax9 and Msx1 genetically interact during mouse craniofacial morphogenesis, and mice deficient for either gene display abnormal tooth and palate development.
Khasawneh, Ramada, Kist, Ralf, Queen, Rachel, Hussain, Rafiqul, Coxhead, Jonathan, Schneider, Jürgen, Mohun, Timothy, Zaffran, Stéphane, Peters, Heiko, Phillips, Helen, Bamforth, Simon   +10 more
openaire   +4 more sources

Msx1is required for dorsal diencephalon patterning [PDF]

Development, 2003
The dorsal midline of the neural tube has recently emerged as a major signaling center for dorsoventral patterning. Msx genes are expressed at the dorsal midline, although their function at this site remains unknown. Using Msx1nlacZ mutant mice, we show that the normal expression domain of Msx1 is interrupted in the pretectum of mutant embryos ...
Antoine, Bach, Yvan, Lallemand, Marie-Anne, Nicola, Casto, Ramos, Luc, Mathis, Mathilde, Maufras, Benoît, Robert   +6 more
openaire   +2 more sources