Results 41 to 50 of about 5,422 (162)

A novel RNA-mediated mechanism causing down-regulation of insulating promoter interactions in human embryonic stem cells

Scientific Reports, 2021
The genome-wide promoter interactome is primarily maintained and regulated by architectural proteins such as CTCF and cohesin. However, some studies suggest a role for non-coding RNAs (ncRNAs) in this process. We aimed to characterise the regulatory role
Yingjuan Liu, Simon G. Williams, Hayden R. Jones, Bernard D. Keavney, Mun-Kit Choy   +4 more
doaj   +1 more source

Establishment of a congenital tooth agenesis related gene MSX1 knockout human embryonic stem cell lines by CRISPR-Cas9 technology

Stem Cell Research, 2017
Human MSX1 gene is mapped to chromosome 4 and encodes a 303aa homeobox protein MSX1. MSX1 expression appears during early tooth development of vertebrate embryogenesis.
Yanting Xue, Minghui Zhu, Dajiang Qin, Yongjin Li, Xiaotong Cen, Xiaofang Sun, Wenwei Lian, Baojian Liao   +7 more
doaj   +1 more source

MSX1 and Orofacial Clefting with and without Tooth Agenesis [PDF]

Journal of Dental Research, 2006
MSX1 has been considered a strong candidate for orofacial clefting, based on mouse expression studies and knockout models, as well as association and linkage studies in humans. MSX1 mutations are also causal for hereditary tooth agenesis. We tested the hypothesis that individuals with orofacial clefting with or without tooth agenesis have MSX1 coding ...
A, Modesto, L M, Moreno, K, Krahn, S, King, A C, Lidral   +4 more
openaire   +2 more sources

Msx homeobox genes critically regulate embryo implantation by controlling paracrine signaling between uterine stroma and epithelium. [PDF]

PLoS Genetics, 2012
The mammalian Msx homeobox genes, Msx1 and Msx2, encode transcription factors that control organogenesis and tissue interactions during embryonic development.
Shanmugasundaram Nallasamy, Quanxi Li, Milan K Bagchi, Indrani C Bagchi   +3 more
doaj   +1 more source

Haploinsufficiency ofMSX1: a Mechanism for Selective Tooth Agenesis [PDF]

Molecular and Cellular Biology, 1998
Previously, we found that the cause of autosomal dominant selective tooth agenesis in one family is a missense mutation resulting in an arginine-to-proline substitution in the homeodomain of MSX1. To determine whether the tooth agenesis phenotype may result from haploinsufficiency or a dominant-negative mechanism, we have performed biochemical and ...
G, Hu, H, Vastardis, A J, Bendall, Z, Wang, M, Logan, H, Zhang, C, Nelson, S, Stein, N, Greenfield, C E, Seidman, J G, Seidman, C, Abate-Shen   +11 more
openaire   +2 more sources

Identification of nuclear localization signals in the human homeoprotein MSX1 [PDF]

Biochemistry and Cell Biology, 2018
MSX1 is one of the homeoproteins with the homeodomain (HD) sequence, which regulates proliferation and differentiation of mesenchymal cells. In this study, we investigated the nuclear localization signal (NLS) in the MSX1 HD by deletion and amino acid substitution analyses. The web-based tool NLStradamus predicted 2 putative basic motifs in the N- and
Shibata, Akio, Machida, Junichiro, Yamaguchi, Seishi, Kimura, Masashi, Tatematsu, Tadashi, Miyachi, Hitoshi, Nakayama, Atsuo, Shimozato, Kazuo, Tokita, Yoshihito   +8 more
openaire   +2 more sources

Secretopathies emerge as a new class of neurocristopathies

Developmental Dynamics, EarlyView.
Abstract Neural crest cells are a transient embryonic population of cells that give rise to a wide range of structures, including craniofacial cartilage and bone, peripheral neurons and glia, as well as components of the cardiac outflow tract, among others.
Amanda Teixeira, Cassandra Millet‐Boureima, Joshua A. Moore, Loydie A. Jerome‐Majewska   +3 more
wiley   +1 more source

Role of MSX1 in Osteogenic Differentiation of Human Dental Pulp Stem Cells

Stem Cells International, 2016
Msh homeobox 1 (MSX1) encodes a transcription factor implicated in embryonic development of limbs and craniofacial tissues including bone and teeth. Although MSX1 regulates osteoblast differentiation in the cranial bone of young animal, little is known ...
Noriko Goto, Katsumi Fujimoto, Sakiko Fujii, Hiroko Ida-Yonemochi, Hayato Ohshima, Takeshi Kawamoto, Mitsuhide Noshiro, Chisa Shukunami, Katsuyuki Kozai, Yukio Kato   +9 more
doaj   +1 more source

Chromatin Remodeller BRD9 Orchestrates Odontoblastic Differentiation via Coordinating RUNX2‐KLF4

Cell Proliferation, EarlyView.
During odontoblast lineage commitment, the chromatin remodeller BRD9 acts as a critical epigenetic coordinator, orchestrating the chromatin landscape to facilitate synergistic binding of key transcription factors RUNX2 and KLF4 to target loci for odontogenesis.
Wenrui Zeng, Yuxiu Lin, Yongyan Gao, Delan Huang, Yuanyuan Li, Honglei Ruan, Guohua Yuan, Huan Liu, Zhi Chen   +8 more
wiley   +1 more source

Msx1 is expressed in retina endothelial cells at artery branching sites

Biology Open, 2012
Summary Msx1 and Msx2 encode homeodomain transcription factors that play a role in several embryonic developmental processes. Previously, we have shown that in the adult mouse, Msx1lacZ is expressed in vascular smooth muscle cells (VSMCs) and pericytes ...
Miguel Lopes, Olivier Goupille, Cécile Saint Cloment, Benoît Robert   +3 more
doaj   +1 more source