Results 41 to 50 of about 6,450 (193)
Stem Cell Research & Therapy, 2018 Background Tooth agenesis, one of the most common developmental anomalies, can affect the function and esthetics of patients. The aim of the present study was to identify genetic clues for familial tooth agenesis and explore the underlying mechanisms ...
Tianyi Xin +6 more
doaj +1 more source
Detection of MSX1 gene mutations in patients with congenital tooth loss in Van der Woude syndrome
口腔疾病防治, 2020 Objective To explore the relationship between MSX1 gene detection and tooth loss in a Van der Woude syndrome (VWS) family. Methods DNA was extracted from the venous blood of 2 patients with dental hy⁃ podontia in the 9th family of Van der Woude ...
DU Xinya +5 more
doaj +1 more source
The MSX1 homeoprotein recruits G9a methyltransferase to repressed target genes in myoblast cells. [PDF]
PLoS ONE, 2012 Although the significance of lysine modifications of core histones for regulating gene expression is widely appreciated, the mechanisms by which these modifications are incorporated at specific regulatory elements during cellular differentiation remains ...
Jingqiang Wang, Cory Abate-Shen
doaj +1 more source
Association of rs8670 Polymorphism in the MSX1 Gene With Non-Syndromic Cleft Lip With or Without Cleft Palate in Malay Population. [PDF]
CureusObjective: This study aimed to investigate the association between variants present in the MSX1 gene and the risk of developing non-syndromic cleft lip with or without cleft palate (NSCL±P) among individuals of Malay ethnicity in Malaysia.
Rashid R +3 more
europepmc +2 more sources
MSX1 mutations and associated disease phenotypes: genotype-phenotype relations [PDF]
European Journal of Human Genetics, 2016 The Msx1 transcription factor is involved in multiple epithelial-mesenchymal interactions during vertebrate embryogenesis. It has pleiotropic effects in several tissues. In humans, MSX1 variants have been related to tooth agenesis, orofacial clefting, and nail dysplasia.
Liang, J. +5 more
openaire +3 more sources
Next generation sequencing reveals a novel nonsense mutation in MSX1 gene related to oligodontia. [PDF]
PLoS ONE, 2018 Tooth agenesis is one of the most common craniofacial disorders in humans. More than 350 genes have been associated with teeth development. In this study, we enrolled 60 child patients (age 13 to 17) with various types of tooth agenesis.
Ondřej Bonczek +9 more
doaj +1 more source
Dynamic expression and regulation of Mage-D1 during tooth development in mice
陆军军医大学学报, 2022 Objective To investigate the dynamic expression profile of mdanoma associated antigen D1 (Mage-D1) at different tooth development stages in mice after birth, and explore the effect of Mage-D1 knockout on tooth development in vivo.
YU Xia +3 more
doaj +1 more source
Scientific Reports, 2021 The genome-wide promoter interactome is primarily maintained and regulated by architectural proteins such as CTCF and cohesin. However, some studies suggest a role for non-coding RNAs (ncRNAs) in this process. We aimed to characterise the regulatory role
Yingjuan Liu +4 more
doaj +1 more source
Stem Cell Research, 2017 Human MSX1 gene is mapped to chromosome 4 and encodes a 303aa homeobox protein MSX1. MSX1 expression appears during early tooth development of vertebrate embryogenesis.
Yanting Xue +7 more
doaj +1 more source
MSX1 and Orofacial Clefting with and without Tooth Agenesis [PDF]
Journal of Dental Research, 2006 MSX1 has been considered a strong candidate for orofacial clefting, based on mouse expression studies and knockout models, as well as association and linkage studies in humans. MSX1 mutations are also causal for hereditary tooth agenesis. We tested the hypothesis that individuals with orofacial clefting with or without tooth agenesis have MSX1 coding ...
A, Modesto +4 more
openaire +2 more sources