Results 51 to 60 of about 6,450 (193)
Msx1 homeodomains bound to DNA.
, 2018 (A) Non-mutant Msx1 homeodomain. (B) Mutant Msx1 homeodomain. Homeodomain is visualized as cartoon.
Vladimir J. Balcar (5728256) +9 more
core +1 more source
Msx homeobox genes critically regulate embryo implantation by controlling paracrine signaling between uterine stroma and epithelium. [PDF]
PLoS Genetics, 2012 The mammalian Msx homeobox genes, Msx1 and Msx2, encode transcription factors that control organogenesis and tissue interactions during embryonic development.
Shanmugasundaram Nallasamy +3 more
doaj +1 more source
Haploinsufficiency ofMSX1: a Mechanism for Selective Tooth Agenesis [PDF]
Molecular and Cellular Biology, 1998 Previously, we found that the cause of autosomal dominant selective tooth agenesis in one family is a missense mutation resulting in an arginine-to-proline substitution in the homeodomain of MSX1. To determine whether the tooth agenesis phenotype may result from haploinsufficiency or a dominant-negative mechanism, we have performed biochemical and ...
G, Hu +11 more
openaire +2 more sources
In silico characterization and structural modeling of a homeobox protein MSX1 from Homo sapiens
Informatics in Medicine Unlocked, 2021 Introduction: MSX1 protein, a homeobox transcriptional regulator plays a significant role in various developmental processes of the mammalian system such as limb-pattern formation, craniofacial development, in particular, odontogenesis, and tumor growth ...
Sneha Singh +4 more
doaj +1 more source
Advanced Science, EarlyView.STAID is a unified deep learning framework that couples iterative pseudo‐spot refinement with neural network training through a feedback loop and exploits gene co‐expression information to model higher‐order interactions, achieving accurate and robust cell‐type deconvolution in spatial transcriptomics.
Jixin Liu +5 more
wiley +1 more source
Nuclear localization of MSX1 variants.
, 2014 Immunolocalizations of FLAG-tagged wild-type, T174I, and L205R MSX1 products were similar when these variants were expressed in HEK293 cells. MSX1 (FLAG, red signal); nuclei (DAPI, blue signal).
Peter Jezewski (610780) +11 more
core +1 more source
, 2012 (A) ChIP-qPCR analyses of H3K27me3 mark on Msx1 target genes in C2C12 cells lacking Msx1 or expressing exogenous Msx1 also expressing the control or G9a siRNA. ChIP data are expressed as relative enrichment of the H3K27me3 mark normalized to input.
Jingqiang Wang (6502) +1 more
core +1 more source
Role of SoxE transcription factors in development and disease
Developmental Dynamics, EarlyView.Abstract Sox8, Sox9, and Sox10 arose by multiple rounds of genome duplications from a single SoxE gene in ancestral vertebrates. In this review, we will briefly discuss the molecular structure and function of SoxE transcription factors and their evolutionary origin. We will then discuss their expression, function, and developmental disorders.
Merin Lawrence, Gerhard Schlosser
wiley +1 more source
Msx1 is expressed in retina endothelial cells at artery branching sites
Biology Open, 2012 Summary Msx1 and Msx2 encode homeodomain transcription factors that play a role in several embryonic developmental processes. Previously, we have shown that in the adult mouse, Msx1lacZ is expressed in vascular smooth muscle cells (VSMCs) and pericytes ...
Miguel Lopes +3 more
doaj +1 more source
Aberrantly Expressed OTX Homeobox Genes Deregulate B-Cell Differentiation in Hodgkin Lymphoma. [PDF]
PLoS ONE, 2015 In Hodgkin lymphoma (HL) we recently reported that deregulated homeobox gene MSX1 mediates repression of the B-cell specific transcription factor ZHX2. In this study we investigated regulation of MSX1 in this B-cell malignancy.
Stefan Nagel +5 more
doaj +1 more source