Results 71 to 80 of about 6,450 (193)

Novel MSX1 frameshift mutation in a Japanese family with nonsyndromic oligodontia

Human Genome Variation, 2021
Congenital tooth agenesis is a common anomaly in humans. We investigated the etiology of human tooth agenesis by exome analysis in Japanese patients, and found a previously undescribed heterozygous deletion (NM_002448.3(MSX1_v001):c.433_449del) in the ...
Junya Adachi, Yoshihiko Aoki, Tadashi Tatematsu, Hiroki Goto, Atsuo Nakayama, Takeshi Nishiyama, Katsu Takahashi, Masatoshi Sana, Akiko Ota, Junichiro Machida, Toru Nagao, Yoshihito Tokita   +11 more
doaj   +1 more source

The neural crest‐associated gene ERRFI1 is involved in melanoma progression and resistance toward targeted therapy

Molecular Oncology, Volume 20, Issue 5, Page 1185-1201, May 2026.
ERRFI1, a neural crest (NC)‐associated gene, was upregulated in melanoma and negatively correlated with the expression of melanocytic differentiation markers and the susceptibility of melanoma cells toward BRAF inhibitors (BRAFi). Knocking down ERRFI1 significantly increased the sensitivity of melanoma cells to BRAFi.
Nina Wang, Qian Sun, Daniel Novak, Lei Zhu, Juliane Poelchen, Tamara Steinfass, Yiman Wang, Viktor Umansky, Jochen Utikal   +8 more
wiley   +1 more source

Association of Msx1 with G9a is required for transcriptional repression.

, 2012
(A) ChIP-qPCR analyses showing relative Msx1 binding in C2C12 cells expressing or lacking Msx1 as well as a control or G9a siRNA. ChIP data are expressed as fold enrichment of Msx1 binding in C2C12 cells expressing Msx1 versus control cells lacking Msx1.
Jingqiang Wang (6502), Cory Abate-Shen (163290)   +1 more
core   +1 more source

Msx1 modulates the Pax9-null cardiovascular phenotype [PDF]

, 2017
PhD ThesisDevelopment of the aortic arch arteries from the pharyngeal arch arteries is a complex process requiring the interaction of several tissue types and tightly regulated gene expression during embryogenesis. In this work, the role of transcription
Khasawneh, Ramada Rateb Abdel Karim
core  

IGFBP5 Restores Endometrial Receptivity and Rescues Implantation Failure in Polycystic Ovary Syndrome

Advanced Science, Volume 13, Issue 27, 13 May 2026.
Impaired endometrial receptivity contributes to the poor pregnancy outcomes in women with PCOS. The authors found that decreased endometrial IL‐22 levels and disrupted STAT3‐IGFBP5 signaling pathway contributed to impaired endometrial receptivity. Supplementation with IL‐22 or IGFBP5 exerts a protective effect on implantation failure in PCOS‐like mice,
Baoying Liao, Chuyu Yun, Hongying Shan, Yuqian Wang, Xiunan Chen, Weisi Lian, Tianliu Peng, Min Zhao, Xunsi Qin, Kailun Hu, Ping Zhou, Yue Wang, Yanli Pang, Rong Li   +13 more
wiley   +1 more source

Dynamic expression of Mage-D1 in rat dental germs and potential role in mineralization of ectomesenchymal stem cells

Scientific Reports, 2022
Mage-D1 (MAGE family member D1) is involved in a variety of cell biological effects. Recent studies have shown that Mage-D1 is closely related to tooth development, but its specific regulatory mechanism is unclear.
Meng Li, Xia Yu, Yuting Luo, Hongyan Yuan, Yixing Zhang, Xiujie Wen, Zhi zhou   +6 more
doaj   +1 more source

Molecular Evolution of the Primate Developmental Genes MSX1 and PAX9 [PDF]

Molecular Biology and Evolution, 2005
In primates, the craniofacial skeleton and the dentition are marked by high levels of interspecific variation. Despite this, there are few comparative species studies conducted at the molecular level to investigate this functional diversity. We have determined nucleotide sequences of MSX1 and PAX9, two developmental genes, in a sample of 27 diverse ...
George H, Perry, Brian C, Verrelli, Anne C, Stone   +2 more
openaire   +2 more sources

The Homeobox Genes: Classification, Regulation, Biological Functions, and Diseases

MedComm, Volume 7, Issue 4, April 2026.
Overview of the homeobox gene superfamily and its pathophysiological roles. The homeobox superfamily comprises several major classes, including ANTP, PRD, TALE, LIM, POU, and others. Among these, the HOX clusters (A–D) play critical roles in embryonic development specifically in conferring cellular identity, regulating morphogenesis, and guiding axial ...
Maedeh Dadzadi, Shahin Ramazi, Mona Darvazi, Sepideh Yoosefi, Melika Abbasi, Shirin Farsad   +5 more
wiley   +1 more source

Functional analysis of tooth agenesis-causing MSX1 mutations.

, 2014
A: myoD-promoter repression activity of T174I and L205R variants in C2C12 cells. The C2C12 cells were cotransfected with an MSX1 expression vector, the firefly luciferase reporter gene driven by the myoD-promoter and sea pansy luciferase reporter gene ...
Peter Jezewski (610780), Munefumi Kamamoto (610776), Kazuo Shimozato (610781), Tadashi Tatematsu (610779), Junichiro Machida (610775), Akio Shibata (610778), Seishi Yamaguchi (610774), Yujiro Higashi (203354), Atsuo Nakayama (185126), Masashi Kimura (610777), Hitoshi Miyachi (403234), Yoshihito Tokita (610782)   +11 more
core   +1 more source

MSX1-Induced Neural Crest-Like Reprogramming Promotes Melanoma\ua0Progression

, 2017
Melanoma cells share many biological properties with neural crest stem cells. Here we show that the homeodomain transcription factor MSX1, which is significantly correlated with melanoma disease progression, reprograms melanocytes and melanoma cells ...
Samir Zaman, Berking, Carola, Mizuho Fukunaga-Kalabis, Joshua X. Wang, Martin Irmler, Wei, Zhi, Rick A. Sturm, Marilda Beqiri, Hristova, Denitsa M., Rauscher, Frank J., Evans, Brianna, Markus V. Heppt, Fisher, David E., Denitsa M. Hristova, Heppt, Markus V., Beqiri, Marilda, Meenhard Herlyn, Zaman, Samir, Herlyn, Meenhard, Li, Ling, Ling Li, Robert Besch, Carola Berking, Sturm, Rick A., Brianna Evans, David E. Fisher, Fukunaga-Kalabis, Mizuho, Jie Zhang, Besch, Robert, Irmler, Martin, Beckers, Johannes, Wang, Joshua X., Zhi Wei, Johannes Beckers, Zhang, Jie, Frank J. Rauscher   +35 more
core   +2 more sources