Results 61 to 70 of about 6,450 (193)

Secretopathies emerge as a new class of neurocristopathies

Developmental Dynamics, EarlyView.
Abstract Neural crest cells are a transient embryonic population of cells that give rise to a wide range of structures, including craniofacial cartilage and bone, peripheral neurons and glia, as well as components of the cardiac outflow tract, among others.
Amanda Teixeira, Cassandra Millet‐Boureima, Joshua A. Moore, Loydie A. Jerome‐Majewska   +3 more
wiley   +1 more source

Effect of MSX1 on the cellular function of cardiomyocytes

Gene
MSX1 (Muscle Segment Homeobox 1) has pleiotropic effects in various tissues, including cardiomyocytes, while the effect of MSX1 on cardiomyocyte cellular function was not well known. In this study, we used AC16 cell culture, real-time fluorescence quantitative PCR (qPCR), protein blotting (Western blot), flow cytometry apoptosis assay and lactate ...
Huang, Linhuan, Zhong, Liangying, Lin, Shaobin, Zhu, Caixia, Cai, Danlei, Huang, Siqi, Hong, Peiming, Kong, Shu, Xie, Yingjun, Luo, Yanmin   +9 more
openaire   +2 more sources

A Comprehensive Review of the Genetic Etiology and Management of Orofacial Clefts

Pediatric Discovery, EarlyView.
ABSTRACT Cleft lip (CL) and cleft palate (CP), collectively referred to as orofacial clefts (OFCs), are among the most common birth defects and can have significant effects on speech, nutrition, and physical and psychosocial development. Manifestation, classification, and treatment plans of OFCs are diverse and not standardized.
Emily Kim, Rebeka Dejenie, Caroline Kim, Russell Reid   +3 more
wiley   +1 more source

Disorders of sex development in Wolf–Hirschhorn syndrome: a genotype–phenotype correlation and MSX1 as candidate gene

Molecular Cytogenetics, 2021
Background Wolf–Hirschhorn (WHS) is a set of congenital physical anomalies and mental retardation associated with a partial deletion of the short arm of chromosome 4.
Khouloud Rjiba, Hédia Ayech, Olfa Kraiem, Wafa Slimani, Afef Jelloul, Imen Ben Hadj Hmida, Nabiha Mahdhaoui, Ali Saad, Soumaya Mougou-Zerelli   +8 more
doaj   +1 more source

Identification of Crucial Drug Targets and Pathways to Reprogram Drug Resistance Through Epigenetic Modulation in Advanced Lung Cancer Using Integrated Bioinformatics Approach

Computational and Systems Oncology, Volume 6, Issue 1, December 2026.
ABSTRACT Resistance to chemotherapy, which is demonstrated in almost every patient with advanced‐stage lung cancer (ALC), underscores an urgent need to unravel the underlying molecular mechanisms and identify novel strategies to overcome drug resistance. In the present study, an attempt was made to identify epigenetic targets and modulators that can be
Okibur Rahman, Mossammat Rima Akter, Nur Alam   +2 more
wiley   +1 more source

MSX1 variants isolated from tooth agenesis patients.

, 2014
A: DNA sequences of MSX1 exon 2 in unaffected (a and b) and affected (c and d) individuals. The C-T transition at position 521 (T174I), and T-G transition in position 614 (L205R) in the mutant sequences cause amino acid substitutions within the MH4 ...
Peter Jezewski (610780), Munefumi Kamamoto (610776), Kazuo Shimozato (610781), Tadashi Tatematsu (610779), Junichiro Machida (610775), Akio Shibata (610778), Seishi Yamaguchi (610774), Yujiro Higashi (203354), Atsuo Nakayama (185126), Masashi Kimura (610777), Hitoshi Miyachi (403234), Yoshihito Tokita (610782)   +11 more
core   +1 more source

Molecular and Genetic Basis of Non-Syndromic Tooth Agenesis

Česká Stomatologie a Praktické Zubní Lékařství, 2015
Background: Tooth agenesis represents the most common anomaly of dental development, which according to Online Mendelian Inheritance in Man (OMIM) database, affects approximately 20% of the population.
L. Kramerová, P. Krejčí, E. Míšová, A. Ševecová   +3 more
doaj   +1 more source

Personalized‐Context‐Aware Age Gap: A New Multi‐Omics Measurement Based on Age‐Enhanced Model AOE‐Net for Aging Acceleration and Chronic Disease Risk Prediction

Aging Cell, Volume 25, Issue 6, June 2026.
Addressing systemic biases in traditional aging clocks, we introduce PAAG, a context‐aware multi‐omics metric derived from the pre‐trained AOE‐Net. PAAG accurately captures localized aging acceleration, demonstrating superior predictive power for chronic disease risks and clinical outcomes across diverse aging populations.
Feng‐Ao Wang, Tao Zeng, Chunchun Yuan, Hongyu Wang, Yule Yu, Enjin Deng, Yao Wang, Jiangxun Ji, Jiarui Cui, Dezhi Tang, Ruikun He, Yongjun Wang, Yixue Li   +12 more
wiley   +1 more source

Characterization of Transcriptional Repressor Gene MSX1 Variations for Possible Associations with Congenital Heart Diseases. [PDF]

PLoS ONE, 2015
The human heart consists of several cell types with distinct lineage origins. Interactions between these cardiac progenitors are very important for heart formation.
Fei-Feng Li, Ying Han, Shuai Shi, Xia Li, Xi-Dong Zhu, Jing Zhou, Qing-Liang Shao, Xue-Qi Li, Shu-Lin Liu   +8 more
doaj   +1 more source

Next‐Generation Strategies for Neural Repair and Regeneration: Neural Organoid Transplantation in the CNS

Cell Proliferation, Volume 59, Issue 6, June 2026.
Neurological disorders are hard to treat. Stem cell‐derived neural organoids enable research, and their transplantation aids CNS therapy, with this article reviewing relevant advances, challenges and prospects. ABSTRACT Neurological disorders are often devastating and notoriously difficult to repair, creating an urgent need for novel research models ...
Yutong Wang, Jinrui Li, Xingjia Mao, Wanyu Wang, Yansong Li, Xuefei Hu, Jinjie Zhong, Fengdong Zhao, Linlin Wang   +8 more
wiley   +1 more source