Results 31 to 40 of about 5,422 (162)
PLoS ONE, 2014 Since MSX1 and PAX9 are linked to the pathogenesis of nonsyndromic tooth agenesis, we performed detailed mutational analysis of these two genes sampled from Japanese patients.
Seishi Yamaguchi +11 more
doaj +1 more source
Stem Cell Research & Therapy, 2018 Background Tooth agenesis, one of the most common developmental anomalies, can affect the function and esthetics of patients. The aim of the present study was to identify genetic clues for familial tooth agenesis and explore the underlying mechanisms ...
Tianyi Xin +6 more
doaj +1 more source
A Nonsyndromic Autosomal Dominant Oligodontia with A Novel Mutation of Pax9-A Clinical and Genetic Report [PDF]
Journal of Clinical and Diagnostic Research, 2015 Oligodontia is congenital absence of one or more teeth which has familial abnormality and attributable to various mutations or polymorphisms of genes often associated with malformative syndromes.
Umapathy Thimmegowda +4 more
doaj +1 more source
Detection of MSX1 gene mutations in patients with congenital tooth loss in Van der Woude syndrome
口腔疾病防治, 2020 Objective To explore the relationship between MSX1 gene detection and tooth loss in a Van der Woude syndrome (VWS) family. Methods DNA was extracted from the venous blood of 2 patients with dental hy⁃ podontia in the 9th family of Van der Woude ...
DU Xinya +5 more
doaj +1 more source
The MSX1 homeoprotein recruits G9a methyltransferase to repressed target genes in myoblast cells. [PDF]
PLoS ONE, 2012 Although the significance of lysine modifications of core histones for regulating gene expression is widely appreciated, the mechanisms by which these modifications are incorporated at specific regulatory elements during cellular differentiation remains ...
Jingqiang Wang, Cory Abate-Shen
doaj +1 more source
MSX1 mutations and associated disease phenotypes: genotype-phenotype relations [PDF]
European Journal of Human Genetics, 2016 The Msx1 transcription factor is involved in multiple epithelial-mesenchymal interactions during vertebrate embryogenesis. It has pleiotropic effects in several tissues. In humans, MSX1 variants have been related to tooth agenesis, orofacial clefting, and nail dysplasia.
Liang, J. +5 more
openaire +3 more sources
Wnt/β-catenin signaling and Msx1 promote outgrowth of the maxillary prominences
Frontiers in Physiology, 2012 Facial morphogenesis requires a series of precisely orchestrated molecular events to promote the growth and fusion of the facial prominences. Cleft palate (CP) results from perturbations in this process.
Marie eMedio +6 more
doaj +1 more source
Next generation sequencing reveals a novel nonsense mutation in MSX1 gene related to oligodontia. [PDF]
PLoS ONE, 2018 Tooth agenesis is one of the most common craniofacial disorders in humans. More than 350 genes have been associated with teeth development. In this study, we enrolled 60 child patients (age 13 to 17) with various types of tooth agenesis.
Ondřej Bonczek +9 more
doaj +1 more source
Dynamic expression and regulation of Mage-D1 during tooth development in mice
陆军军医大学学报, 2022 Objective To investigate the dynamic expression profile of mdanoma associated antigen D1 (Mage-D1) at different tooth development stages in mice after birth, and explore the effect of Mage-D1 knockout on tooth development in vivo.
YU Xia +3 more
doaj +1 more source
Msx1 and Msx2 promote meiosis initiation
Development, 2011 The mechanisms regulating germ line sex determination and meiosis initiation are poorly understood. Here, we provide evidence for the involvement of homeobox Msx transcription factors in foetal meiosis initiation in mammalian germ cells. Upon meiosis initiation, Msx1 and Msx2 genes are strongly expressed in the foetal ovary, possibly stimulated by ...
Le Bouffant, Ronan +8 more
openaire +3 more sources