Results 31 to 40 of about 6,450 (193)

Dedifferentiation of Mammalian Myotubes Induced by msx1 [PDF]

Cell, 2000
The process of cellular differentiation culminating in terminally differentiated mammalian cells is thought to be irreversible. Here, we present evidence that terminally differentiated murine myotubes can be induced to dedifferentiate. Ectopic expression of msx1 in C2C12 myotubes reduced the nuclear muscle proteins MyoD, myogenin, MRF4, and p21 to ...
Odelberg, Shannon J., Kollhoff, Angela, Keating, Mark T.   +2 more
openaire   +2 more sources

Generation of a MSX1 knockout human embryonic stem cell line using CRISPR/Cas9 technology

Stem Cell Research, 2022
The MSX1 gene encodes a transcriptional repressor and plays important roles in limb-pattern formation, craniofacial development, and odontogenesis during vertebrate embryogenesis.
Weicheng Chiu, Anqi Li, Tao Wang, Weiqiang Li, Xinchun Zhang   +4 more
doaj   +1 more source

The Role of MSX1 in Human Tooth Agenesis [PDF]

Journal of Dental Research, 2002
MSX1 has a critical role in craniofacial development, as indicated by expression assays and transgenic mouse phenotypes. Previously, MSX1 mutations have been identified in three families with autosomal-dominant tooth agenesis. To test the hypothesis that MSX1 mutations are a common cause of congenital tooth agenesis, we screened 92 affected individuals,
A C, Lidral, B C, Reising
openaire   +2 more sources

Detection of a rare AXIN2 variant in an Iranian family with hypodontia and oligodontia [PDF]

Journal of Dental Research, Dental Clinics, Dental Prospects, 2022
Background. Hypodontia, or the absence of one or more teeth during tooth formation, is a highly prevalent dental anomaly. Nevertheless, the main causes are still unknown.
Shiva Safari, Asghar Ebadifar, Hossien Najmabadi, Koorosh Kamali, Seyedeh Sedigheh Abedini, Mohammad Mousavi   +5 more
doaj   +1 more source

Expression of MSX1, HOXA11 and TP53I3 in the endometrium associated with the onset of pregnancy after repeated failed IVF attempts in patients with tubo-peritoneal factor infertility

Гинекология, 2020
Relevance. The success of the in vitro fertilisation (IVF) program, among other factors, depends on the readiness of the endometrium to accept the embryo.
Ekaterina A. Knyazeva, Maria V. Kuznetsova, Olga V. Burmenskaya, Andrey E. Donnikov, Elena A. Kalinina   +4 more
doaj   +1 more source

70759 Jaw-specific control of Msx1-dependent odontogenesis by Dkk2 and Sostdc1

Journal of Clinical and Translational Science, 2021
IMPACT: Our proposed jaw-specific control mechanism of tooth development is expected to address the site-specific prevalence of tooth agenesis in humans. OBJECTIVES/GOALS: To determine the molecular mechanisms that control jaw-specific tooth development.
Hyuk-Jae Edward Kwon
doaj   +1 more source

An aberrant splice acceptor site due to a novel intronic nucleotide substitution in MSX1 gene is the cause of congenital tooth agenesis in a Japanese family. [PDF]

PLoS ONE, 2015
Congenital tooth agenesis is caused by mutations in the MSX1, PAX9, WNT10A, or AXIN2 genes. Here, we report a Japanese family with nonsyndromic tooth agenesis caused by a novel nucleotide substitution in the intronic region between exons 1 and 2 of the ...
Tadashi Tatematsu, Masashi Kimura, Mitsuko Nakashima, Junichiro Machida, Seishi Yamaguchi, Akio Shibata, Hiroki Goto, Atsuo Nakayama, Yujiro Higashi, Hitoshi Miyachi, Kazuo Shimozato, Naomichi Matsumoto, Yoshihito Tokita   +12 more
doaj   +1 more source

Msx1 haploinsufficiency modifies the Pax9-deficient cardiovascular phenotype [PDF]

BMC Developmental Biology, 2021
Abstract Background Successful embryogenesis relies on the coordinated interaction between genes and tissues. The transcription factors Pax9 and Msx1 genetically interact during mouse craniofacial morphogenesis, and mice deficient for either gene display abnormal tooth and palate development.
Khasawneh, Ramada, Kist, Ralf, Queen, Rachel, Hussain, Rafiqul, Coxhead, Jonathan, Schneider, Jürgen, Mohun, Timothy, Zaffran, Stéphane, Peters, Heiko, Phillips, Helen, Bamforth, Simon   +10 more
openaire   +4 more sources

Msx1is required for dorsal diencephalon patterning [PDF]

Development, 2003
The dorsal midline of the neural tube has recently emerged as a major signaling center for dorsoventral patterning. Msx genes are expressed at the dorsal midline, although their function at this site remains unknown. Using Msx1nlacZ mutant mice, we show that the normal expression domain of Msx1 is interrupted in the pretectum of mutant embryos ...
Antoine, Bach, Yvan, Lallemand, Marie-Anne, Nicola, Casto, Ramos, Luc, Mathis, Mathilde, Maufras, Benoît, Robert   +6 more
openaire   +2 more sources

A Nonsyndromic Autosomal Dominant Oligodontia with A Novel Mutation of Pax9-A Clinical and Genetic Report [PDF]

Journal of Clinical and Diagnostic Research, 2015
Oligodontia is congenital absence of one or more teeth which has familial abnormality and attributable to various mutations or polymorphisms of genes often associated with malformative syndromes.
Umapathy Thimmegowda, Praveen Prasanna, Anantharaj Athimuthu, Prasanna Kumar Bhat, Yogish Puttashamachari   +4 more
doaj   +1 more source