Results 1 to 10 of about 1,570 (79)
PLoS Genetics, 2020 Dysregulation of ribosome production can lead to a number of developmental disorders called ribosomopathies. Despite the ubiquitous requirement for these cellular machines used in protein synthesis, ribosomopathies manifest in a tissue-specific manner ...
Katherine I Farley-Barnes +4 more
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Integrated Genetic Networks and Epigenetic Regulation inTooth Development and Maturation [PDF]
CellsTooth development or odontogenesis is a complex morphogenetic process that requires tightly regulated interactions between the oral epithelium and mesenchyme of neural crest origin.
Dong-Joon Lee +2 more
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Pax9 regulates a molecular network involving Bmp4, Fgf10, Shh signaling and the Osr2 transcription factor to control palate morphogenesis [PDF]
Development (Cambridge), 2013 Cleft palate is one of the most common birth defects in humans. Whereas gene knockout studies in mice have shown that both the Osr2 and Pax9 transcription factors are essential regulators of palatogenesis, little is known about the molecular mechanisms involving these transcription factors in palate development. We report here that Pax9 plays a crucial
Yu Lan, Rulang Jiang, Shihai Jia
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Human PLU-1 Has Transcriptional Repression Properties and Interacts with the Developmental Transcription Factors BF-1 and PAX9 [PDF]
Journal of Biological Chemistry, 2003 PLU-1 is a large (1544 amino acids) nuclear protein that is highly expressed in breast cancers and is proposed to function as a regulator of gene expression. A yeast two-hybrid screen using PLU-1 as bait has identified two unrelated PLU-1 interacting proteins, namely brain factor-1 (BF-1) and paired box 9 (PAX9), both of which are developmental ...
Paul Freemont +2 more
exaly +4 more sources
Biomedicines, 2022 Periodontal ligament stem cells (PDLSCs) play central roles in periodontal ligament (PDL) tissue homeostasis, repair, and regeneration. Previously, we established a protocol to differentiate human-induced pluripotent stem cell-derived neural crest-like ...
Risa Sugiura +10 more
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PAX9 and MSX1 transcription factor genes in non-syndromic dental agenesis
Archives of Oral Biology, 2011 The molecular variation of paired domain box gene 9 (PAX9) was previously investigated by our research group and a high degree of evolutionary conservation in coding and non-coding regions was observed except in exon 3. PAX9 is a transcription factor important in tooth development, and we wanted to verify its role in dental agenesis in detail.
Maria Cátira Bortolini +1 more
exaly +3 more sources
Functional Screenings Identify Regulatory Variants Associated with Breast Cancer Susceptibility
Current Issues in Molecular Biology, 2021 Genome-wide association studies (GWAS) have identified more than 2000 single nucleotide polymorphisms (SNPs) associated with breast cancer susceptibility, most of which are located in the non-coding region.
Naixia Ren +5 more
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Pax9’s Interaction With the Ectodysplasin Signaling Pathway During the Patterning of Dentition
Frontiers in Physiology, 2020 In these studies, we explored for the first time the molecular relationship between the paired-domain-containing transcription factor, Pax9, and the ectodysplasin (Eda) signaling pathway during mouse incisor formation.
Shihai Jia +9 more
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Transcriptional analysis of the human PAX9 promoter
Journal of Applied Oral Science, 2010 OBJECTIVES: PAX9 belongs to the Pax family of transcriptional factor genes. This gene is expressed in embryonic tissues such as somites, pharyngeal pouch endoderm, distal limb buds and neural crest-derived mesenchyme.
Carolina Vieira de Almeida +4 more
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Journal of Applied Oral Science, 2007 PURPOSE: Hypodontia is the congenital absence of one or more (up to six) permanent and/or deciduous teeth, being one of the most common alterations of the human dentition.
Fabio José Bianch +4 more
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