Results 1 to 10 of about 1,588 (94)
PLoS Genetics, 2020 Dysregulation of ribosome production can lead to a number of developmental disorders called ribosomopathies. Despite the ubiquitous requirement for these cellular machines used in protein synthesis, ribosomopathies manifest in a tissue-specific manner ...
Katherine I Farley-Barnes +4 more
doaj +5 more sources
Integrated Genetic Networks and Epigenetic Regulation inTooth Development and Maturation [PDF]
CellsTooth development or odontogenesis is a complex morphogenetic process that requires tightly regulated interactions between the oral epithelium and mesenchyme of neural crest origin.
Dong-Joon Lee +2 more
doaj +2 more sources
Pax9 regulates a molecular network involving Bmp4, Fgf10, Shh signaling and the Osr2 transcription factor to control palate morphogenesis [PDF]
Development (Cambridge), 2013 Cleft palate is one of the most common birth defects in humans. Whereas gene knockout studies in mice have shown that both the Osr2 and Pax9 transcription factors are essential regulators of palatogenesis, little is known about the molecular mechanisms involving these transcription factors in palate development. We report here that Pax9 plays a crucial
Yu Lan, Shihai Jia, Rulang Jiang
exaly +3 more sources
PAX9 and MSX1 transcription factor genes in non-syndromic dental agenesis
Archives of Oral Biology, 2011 The molecular variation of paired domain box gene 9 (PAX9) was previously investigated by our research group and a high degree of evolutionary conservation in coding and non-coding regions was observed except in exon 3. PAX9 is a transcription factor important in tooth development, and we wanted to verify its role in dental agenesis in detail.
Vanessa Rodrigues Paixão-Côrtes +1 more
exaly +3 more sources
Biomedicines, 2022 Periodontal ligament stem cells (PDLSCs) play central roles in periodontal ligament (PDL) tissue homeostasis, repair, and regeneration. Previously, we established a protocol to differentiate human-induced pluripotent stem cell-derived neural crest-like ...
Risa Sugiura +10 more
doaj +3 more sources
Human PLU-1 Has Transcriptional Repression Properties and Interacts with the Developmental Transcription Factors BF-1 and PAX9 [PDF]
Journal of Biological Chemistry, 2003 PLU-1 is a large (1544 amino acids) nuclear protein that is highly expressed in breast cancers and is proposed to function as a regulator of gene expression. A yeast two-hybrid screen using PLU-1 as bait has identified two unrelated PLU-1 interacting proteins, namely brain factor-1 (BF-1) and paired box 9 (PAX9), both of which are developmental ...
Kirsten Jensen +2 more
exaly +4 more sources
Pax9’s Interaction With the Ectodysplasin Signaling Pathway During the Patterning of Dentition
Frontiers in Physiology, 2020 In these studies, we explored for the first time the molecular relationship between the paired-domain-containing transcription factor, Pax9, and the ectodysplasin (Eda) signaling pathway during mouse incisor formation.
Shihai Jia +9 more
doaj +3 more sources
The Evolution of Gene Sequencing Technologies: Unveiling Genetic Architecture of Nonsyndromic Orofacial Clefts. [PDF]
Genet Res (Camb)Nonsyndromic orofacial clefts (NSOC) are common congenital craniofacial developmental defects. Current evidence suggests that genetic factors, environmental exposures, and their interactions jointly contribute to the development of the disease. Owing to the high heritability of NSOC, identifying susceptibility genes and loci is a central focus of ...
Zhao H, Zhang S, Zhu H, Jia Z.
europepmc +2 more sources
Expression Characteristics of PAX7 and Its Prognostic Correlation in Breast Cancer. [PDF]
Breast JObjective To conduct a thorough analysis of public databases to investigate the expression patterns of the PAX7 gene in breast cancer. Methods We gathered gene expression data, clinical details, immunohistochemistry images, and genomic information from breast cancer patients through various public databases, such as TCGA, THPA, GEPIA, and cBioPortal ...
Silafu B, Huang J, Aizezi X.
europepmc +2 more sources
A Modular Bioinstructive Platform Reveals Mechanistic Insights into Additive-Free, Topography-Driven Osteogenesis. [PDF]
Adv Healthc MaterEngineered microparticle topographies direct human mesenchymal stem cell osteogenesis without biochemical additives. This osteogenic commitment is driven by canonical Hedgehog signaling and followed by temporal IGF‐II engagement. Two‐photon polymerization demonstrates spatial control, enabling the engineering of topographical gradients that pattern ...
Ghuloum FI +5 more
europepmc +2 more sources