Results 21 to 30 of about 1,589 (95)

From Association to Mechanism: Regulatory Annotation and Pathway Mapping of Genes Surrounding Breast Cancer Risk Variants

Computational and Systems Oncology, Volume 6, Issue 1, December 2026.
ABSTRACT Inherited factors account for a large share of breast cancer susceptibility, yet the biological consequences of most risk variants are still poorly understood. To address this gap, we studied 175 breast cancer risk variants confirmed by genome‐wide association studies and gathered the genes that lie near them.
Sultana Jannat, Trina Mitra, Nafisa Nawar Fariha, Tasmia Tabassum, Kulsuma Bahar Bethi, Synchita Majumder Kaya, Md. Arif Hossen, Md. Saad Hossain, Jobaier Ibne Deen, Mohammed Emon, Laila Khaleda, Md. Hridoy Ahmed   +11 more
wiley   +1 more source

HOXA3 functions as the on-off switch to regulate the development of hESC-derived third pharyngeal pouch endoderm through EPHB2-mediated Wnt pathway

Frontiers in Immunology
ObjectivesNormal commitment of the endoderm of the third pharyngeal pouch (3PP) is essential for the development and differentiation of the thymus. The aim of this study was to investigate the role of transcription factor HOXA3 in the development and ...
Yingjie Fu, Yingjie Fu, Xueyan Zhang, Xueyan Zhang, Haibin Wu, Haibin Wu, Pingping Zhang, Shoupei Liu, Shoupei Liu, Tingting Guo, Tingting Guo, Huanhuan Shan, Huanhuan Shan, Yan Liang, Yan Liang, Honglin Chen, Honglin Chen, Jinghe Xie, Jinghe Xie, Yuyou Duan, Yuyou Duan, Yuyou Duan, Yuyou Duan   +22 more
doaj   +1 more source

Light‐Inducible Activation of FGFR3 Facilitates Chondrocyte Maturation

Cell Proliferation, Volume 59, Issue 7, July 2026.
Light‐inducible activation of FGFR3 induced robust activation of MAPK signaling, promoting proliferation and collagen depositon in induced chondrocytes and prevent the degeneration of osteoarthritic chondrocytes.
Mengze Sun, Yun Zhao, Yuqing Du, Yifei Fan, Kai Wang, Xiaoqing Hu   +5 more
wiley   +1 more source

A Combination of Variants in SEPTIN9 and MSX1 Genes Leads to the Formation of Orofacial Clefts

Genes to Cells, Volume 31, Issue 4, July 2026.
Double‐depleted Xenopus embryos of xMSX1 and xSEPTIN9 exhibited orofacial clefts, and wild‐type but not variants in human MSX1 and human SEPTIN9 mRNAs could rescue the phenotype of morphants, indicating that variants in MSX1 and SEPTIN9, each individually tolerated, synergistically disrupt craniofacial morphogenesis to cause orofacial clefts.
Udval Uuganbayar, Zarko Manojlovic, Nao Ito, Reiko Yamaguchi, Hiromasa Ninomiya, Issei S. Shimada, Chisato Yamada, Devin Feigelson, Gretchen Schulz, Allyn Auslander, Sylvia Rakotoarison, William Magee III, Yutaka Hashimoto, Yoichi Kato   +13 more
wiley   +1 more source

Deletion of a Pax1 Sex‐Associated Genomic Region Associated With Adolescent Idiopathic Scoliosis Leads to Disc Degeneration, Instability, and Vertebral Rotation in Mice

JOR SPINE, Volume 9, Issue 2, June 2026.
Overview of the effects of Pax1‐SAR deletion on gene expression, IVD degeneration, and resultant scoliotic‐like curvature between sexes. Proposed mechanism of sex‐dependent changes in gene expression in females (right) and males (left), resulting in sex‐dependent disc degeneration and scoliotic phenotypes.
Edward C. Moody, Emma M. Wade, Shuji Mizumoto, Jeremy McCallum‐Loudeac, Megan J. Wilson   +4 more
wiley   +1 more source

The Homeobox Genes: Classification, Regulation, Biological Functions, and Diseases

MedComm, Volume 7, Issue 4, April 2026.
Overview of the homeobox gene superfamily and its pathophysiological roles. The homeobox superfamily comprises several major classes, including ANTP, PRD, TALE, LIM, POU, and others. Among these, the HOX clusters (A–D) play critical roles in embryonic development specifically in conferring cellular identity, regulating morphogenesis, and guiding axial ...
Maedeh Dadzadi, Shahin Ramazi, Mona Darvazi, Sepideh Yoosefi, Melika Abbasi, Shirin Farsad   +5 more
wiley   +1 more source

International Registry of NKX2‐1‐Related Disorders: Clinical, Genetic, and Imaging Perspectives

Movement Disorders, Volume 41, Issue 4, Page 889-900, April 2026.
Abstract Background NKX2‐1–related disorders result from heterozygous variants in NKX2‐1, a gene crucial for brain, lung, and thyroid development. Although movement disorders, hypothyroidism, and neonatal respiratory distress are recognized, the full phenotype and genotype–phenotype relationships remain incompletely defined.
Laia Nou‐Fontanet, Claudia Ravelli, Lydie Burglen, Sol Balsells Mejia, Angel Valls‐Villalba, Elies Roman Schiffels, Alice Innocenti, Beatriz Villafuerte, Ainara Salazar‐Villacorta, Vicente Quiroz, Andrea Sariego Jamardo, Giulia Bonato, Asun Díaz‐Gomez, Alexandra Afenjar, Catheline Vilain, Patricia Dumke da Silva Möller, Deyanira Garcia‐Navas Nuñez, Magdalena Krygier, Maria Judit Molnar, Łukasz Milanowski, Katrin Õunap, Micaela Pauni, Patricia Vega, Raphael Borie, Milena Villamil‐Osorio, Sanem Yilmaz, Dénes Zádori, Marta Zawadzka, Tahsin Stefan Barakat, Sebastian Neuens, Daniel de Natera‐de Benito, Dídac Casas‐Alba, Luca Soliani, Claudio M. de Gusmao, Giacomo Garone, Nicola Specchio, Miryam Carecchio, José C. Moreno, Francesca Magrinelli, Kailash P. Bhatia, Darius Ebrahimi‐Fakhari, Claudia Castiglioni, Manju Ann Kurian, João Nuno Carvalho, Roser Pons, Emmanuel Roze, Diane Doummar, Juan Darío Ortigoza‐Escobar   +47 more
wiley   +1 more source

Human Atlas of Tooth Decay Progression: Identification of Cellular Mechanisms Driving the Switch from Dental Pulp Repair Toward Irreversible Pulpitis

Advanced Science, Volume 13, Issue 8, 9 February 2026.
Tooth decay progression transforms the dental pulp response from repair to fibrosis. At early stages, stromal cells reprogram to repair the extra cellular matrix (ECM), blood vessels, and nerves, remodel and grow, keeping repair possible. In advanced decay, hypoxia, and vessel regression, in complement with an immune switch, fuel nerve degeneration and
Hoang Thai Ha, Sofya Kosmynina, Amandine Verocq, Keremsah Ozen, Ines Tekia, Hugo Bussy, Marie Ramirez, Dima Sabbah, Chloe Goemans, Valerie Vandenbempt, Esteban N. Gurzov, Sumeet Pal Singh, Nicolas Baeyens   +12 more
wiley   +1 more source

Lysine Acetyltransferase 6 in Health and Disease

MedComm, Volume 6, Issue 12, December 2025.
KAT6A and its paralog KAT6B have emerged as druggable targets for the treatment of malignancies, especially for breast cancer. Recent progress in drug discovery has promoted the development of dual inhibitors targeting KAT6A and KTA6B, which shows potent antitumor efficacy and manageable toxicity.
Yujing Tan, Jiani Wang, Fei Ma
wiley   +1 more source

Harnessing Oxidized Alginate Microgels for Rapid and Self‐Assembling Dental Tissue Organogenesis In Vitro and In Vivo

Small Science, Volume 5, Issue 12, December 2025.
The system employs a high density human dental stem cells‐laden oxidized alginate‐based microgel with a "degrade‐to‐active" paradigm that mimics cellular condensation to enhance cell viability, achieve robust vascularization, and promote subsequent dental organogenesis, which is enabled by rapid degradation along with the elimination of residual ...
Chao Liang, Shuxuan Wu, Ziqi Huang, Zhenzhen Wu, Siyuan Chen, Feiming Li, Karrie Mei‐Yee Kiang, Gilberto Ka‐Kit Leung, Indong Jun, Hwan D. Kim, Ann‐Na Cho, Hee Jung Lee, Honghyun Park, Yiu Yan Leung, Seong Jun Kim, Seil Sohn, Haram Nah, Jae Seo Lee, Il Keun Kwon, Dong‐Nyoung Heo, Sang‐woo Lee, Zhaoming Wu, Sang Jin Lee   +22 more
wiley   +1 more source