Results 41 to 50 of about 1,648 (133)

Deconstructing the Thymic Microenvironment Through Genesis to Senescence

Immunological Reviews, Volume 332, Issue 1, July 2025.
ABSTRACT The thymus is essential for adaptive immunity, orchestrating the differentiation of hematopoietic progenitors into various T‐cell lineages. Thymic epithelial cells (TECs) impart this unique function by mediating the major checkpoints in T‐cell differentiation while also imposing stringent tolerance processes required to prevent autoimmunity ...
Michael D'Andrea, Kelin Zhao, Daniel H. D. Gray   +2 more
wiley   +1 more source

Functional Analyses of SATB2 Variants Reveal Pathogenicity Mechanisms Linked With SATB2‐Associated Syndrome

American Journal of Medical Genetics Part A, Volume 197, Issue 6, June 2025.
ABSTRACT SATB2‐associated syndrome (SAS) is characterized by intellectual disability, neurodevelopmental disorders, cleft palate, and dental abnormalities. SAS is caused by variants in the special AT‐rich sequence‐binding protein 2 (SATB2), which encodes a transcription factor containing two CUT domains and a homeobox (HOX) domain.
Nao Ukita, Takuya Ogawa, Mamiko Yamada, Chisen Takeuchi, Kenjiro Kosaki, Keiji Moriyama   +5 more
wiley   +1 more source

Pax1/Pax9-Related Genes in an Agnathan Vertebrate, Lampetra japonica: Expression Pattern of LjPax9 Implies Sequential Evolutionary Events toward the Gnathostome Body Plan

, 2000
Among the transcription factor gene families, Pax genes play important and unique roles in morphological patterning of animal body plans. Of these, Group I Pax genes (Pax1 and Pax9) are expressed in the endodermal pharyngeal pouches in many groups of ...
Ogasawara, Michio, Shigetani, Yasuyo, Satoh, Nori, Hirano, Shigeki, Kuratani, Shigeru   +4 more
core   +1 more source

An Approach for Differential Diagnosis of Breast Tumors by ctDNA Methylation Sequencing

Cancer Medicine, Volume 14, Issue 12, June 2025.
ABSTRACT Background Breast ultrasonography and mammography remain predominant in breast tumor evaluations, yet they often result in false positives, particularly for tumors classified as BI‐RADS 4a or those no more than 10 mm, which are not ideal for core needle biopsy (CNB).
Xianyu Zhang, Yanling Yin, Zhujia Ye, Xingda Zhang, Wei Wei, Yi Hao, Liuhong Zeng, Ting Yang, Dalin Li, Jun Wang, Dezhi Zhao, Yanbo Chen, Shan Lei, Yongdong Jiang, Youxue Zhang, Shouping Xu, Abiyasi Nanding, Yajie Gong, Siwei Li, Yuanyuan Yu, Shilu Zhao, Siyu Liu, Yashuang Zhao, Zhiwei Chen, Shihui Yu, Jian‐Bing Fan, Da Pang   +26 more
wiley   +1 more source

Pax9 and Jagged1 act downstream of Gli3 in vertabrate limb development

, 2005
From early in limb development the transcription factor Gli3 acts to define boundaries of gene expression along the anterior-posterior (AP) axis, establishing asymmetric patterns required to provide positional information.
Soares, Marcelo Bento, Mo, Rong, Forrest, Alistair, Fiorenza, Salvatore, Grimmond, Sean, McGlinn, Edwina, Fatima Bonaldo, Maria, Wicking, Carol, Bonaldo, Maria de Fatima, Lammerts van Bueren, Kelly, Hui, Chi-chung, M. Poh, Alisa, Poh, Alisa M., Wainwright, Brandon, van Bueren, Kelly Lammerts   +14 more
core   +1 more source

Identification and Functional Analysis of Novel Mutations in AXIN2 and LRP6 Linked With Non‐Syndromic Tooth Agenesis

Molecular Genetics &Genomic Medicine, Volume 13, Issue 5, May 2025.
Our study expands the spectrum of AXIN2 and LRP6 mutations associated with non‐syndromic TA. The functional evidence supports the pathogenicity of suppression and excessive activation of the Wnt signaling pathway in TA. ABSTRACT Background Tooth agenesis (TA) ranks among the most common dental abnormalities. This study aimed to explore the etiology and
Wendi Luo, Haitang Yue, Guangtai Song, Jing Cheng, Miao He   +4 more
wiley   +1 more source

Absence of Pax9 causes an endoderm-specific disruption of the Shh pathway in taste papillae.

, 2014
(A–F) Whole mount in situ hybridization of Shh, its receptor (Ptc1) and the downstream effector transcription factor (Gli1) at E14.5. (A,B) In the wild type CVP (A), Shh is expressed in the central dome as well as in a ring of accessory papillae ...
Ralf Kist (641672), Moira Crosier (407428), Heiko Peters (73270), Max Robinson (480473), Jennifer Fuchs (641674), Julia Reichelt (641675), Michelle Watson (641673)   +6 more
core   +1 more source

An Intervertebral Disc (IVD) Regeneration Model Using Human Nucleus Pulposus Cells (iHNPCs) and Annulus Fibrosus Cells (iHAFCs)

Advanced Healthcare Materials, Volume 14, Issue 10, April 15, 2025.
This study investigates hTert‐immortalized human nucleus pulposus (iHNPCs) and annulus fibrosus (iHAFCs) cells for intervertebral disc (IVD) regeneration and spinal fusion models. A 3D‐printed citrate‐based scaffold loaded with BMP9‐stimulated iHAFCs and BMP2‐stimulated iHNPCs effectively promotes bone and cartilage formation, mimicking the IVD ...
Yi Zhu, Qing Liu, Chao Yu, Hui Zhang, Jiamin Zhong, Yonghui Wang, Ou Mei, Ethan Gerhard, Wulin You, Guowei Shen, Changqi Luo, Xingye Wu, Jingjing Li, Yi Shu, Ya Wen, Usman Zeb, Hue H. Luu, Michael J. Lee, Lewis L. Shi, Yang Bi, Jian Yang, Jiaming Fan, Russell R. Reid, Tong‐Chuan He, Liangyuan Wen   +24 more
wiley   +1 more source

Msx1 Mutations

, 2011
Mutations in the transcription factors PAX9 and MSX1 cause selective tooth agenesis in humans. In tooth bud mesenchyme of mice, both proteins are required for the expression of Bmp4, which is the key signaling factor for progression to the next step of ...
H. Kong, R. D’Souza, Y. Wang, G. Mues
core   +1 more source

Transcriptional analysis of the human PAX9 promoter

, 2015
Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)Objectives: PAX9 belongs to the Pax family of transcriptional factor genes. This gene is expressed in embryonic tissues such as somites, pharyngeal pouch endoderm, distal limb buds and neural ...
de Andrade, SC, de Almeida, CV, Ramenzoni, LL, Line, SRP, Saito, CPB   +4 more
core