Results 31 to 40 of about 1,589 (95)

Comparative Transcriptomics Reveals a Dual Role of the Epidermal Differentiation Complex in the Skin and the Oesophagus

Experimental Dermatology, Volume 34, Issue 12, December 2025.
ABSTRACT The epidermal differentiation complex (EDC) is a cluster of genes implicated in the control of the skin barrier. However, some EDC genes are also expressed at high levels in the human oesophagus. To determine whether the expression of EDC genes in the oesophagus is evolutionarily conserved, we performed comparative transcriptomic analyses of ...
Attila Placido Sachslehner, Julia Lachner, Veronika Mlitz, Bahar Golabi, Claudia Hess, Wolfgang Sipos, Leopold Eckhart   +6 more
wiley   +1 more source

E‐Cigarette and Vanillin Exposure Disrupts Cardiovascular Development in Xenopus laevis

Birth Defects Research, Volume 117, Issue 10, October 2025.
ABSTRACT Introduction Congenital heart defects (CHDs) are a leading cause of perinatal mortality, and maternal cigarette smoking is a well‐established risk factor. In recent years, electronic cigarette (e‐cigarette) use has surged, yet its safety during pregnancy remains poorly defined.
James E. Black III, Thomas O. Raymond, Amanda J. G. Dickinson   +2 more
wiley   +1 more source

Deconstructing the Thymic Microenvironment Through Genesis to Senescence

Immunological Reviews, Volume 332, Issue 1, July 2025.
ABSTRACT The thymus is essential for adaptive immunity, orchestrating the differentiation of hematopoietic progenitors into various T‐cell lineages. Thymic epithelial cells (TECs) impart this unique function by mediating the major checkpoints in T‐cell differentiation while also imposing stringent tolerance processes required to prevent autoimmunity ...
Michael D'Andrea, Kelin Zhao, Daniel H. D. Gray   +2 more
wiley   +1 more source

Functional Analyses of SATB2 Variants Reveal Pathogenicity Mechanisms Linked With SATB2‐Associated Syndrome

American Journal of Medical Genetics Part A, Volume 197, Issue 6, June 2025.
ABSTRACT SATB2‐associated syndrome (SAS) is characterized by intellectual disability, neurodevelopmental disorders, cleft palate, and dental abnormalities. SAS is caused by variants in the special AT‐rich sequence‐binding protein 2 (SATB2), which encodes a transcription factor containing two CUT domains and a homeobox (HOX) domain.
Nao Ukita, Takuya Ogawa, Mamiko Yamada, Chisen Takeuchi, Kenjiro Kosaki, Keiji Moriyama   +5 more
wiley   +1 more source

Genetic architecture of craniofacial morphogenesis: roles of <i>PAX3</i>, <i>PAX7</i>, and <i>PAX9</i>. [PDF]

Front Cell Dev Biol
Wang K, Li N, Liu W, Li YG, Ren F.
europepmc   +1 more source

A Signaling-Threshold Framework for Human Tooth Agenesis: Integrating Molecular Genetics with Developmental Field Theory. [PDF]

Int J Mol Sci
Kuc AE, Kuc P, Kuc N, Sulewska M, Tylicka M, Sarul M.   +5 more
europepmc   +1 more source

MSX1 and PAX9 Polymorphisms and Their Association With Lateral Incisor Morphology in Patients With Maxillary Canine Impaction. [PDF]

Med Sci Monit
Todorović A, Filipović G, Stefanović N, Vujić S, Todorović K, Mitić V, Janošević P, Radojičić J, Šćepan I.   +8 more
europepmc   +1 more source

Epigenetic, Genetic, and Functional Germline Alterations of <i>PAX</i> Genes in Human Pathology: A Comprehensive Update. [PDF]

Curr Issues Mol Biol
Gomez VL, Wegner S, Ocejo S, Perez D, Jabbour D, Fernandez V, Abulaban A, Bahmad M, Elajami TK, Abou-Kheir W, Bahmad HF.   +10 more
europepmc   +1 more source

Toward Understanding the Role of miRNAs in Cleft Palate Only: Observations from Patient Tissues and In Vitro Assays. [PDF]

Int J Mol Sci
Palmieri A, Scapoli L, Pellati A, Apolloni F, Zanchi V, Spinelli G, Sgarzani R, Carinci F, Martinelli M.   +8 more
europepmc   +1 more source

Unrevealing the dual role of paired box and sex determining region Y related high mobility group box in glioblastoma. [PDF]

Discov Oncol
Polley K, Firdous SM.
europepmc   +1 more source