Results 31 to 40 of about 1,648 (133)
Nine Novel PAX9 Mutations and a Distinct Tooth Agenesis Genotype-Phenotype
, 2017 Tooth agenesis is one of the most common developmental anomalies affecting function and esthetics. The paired-domain transcription factor, Pax9, is critical for patterning and morphogenesis of tooth and taste buds. Mutations of PAX9 have been identified
H. Zhang +13 more
core +1 more source
Transforming growth factor-β signaling in thymic epithelial cells : its role in development, steady-state and immune reconstitution [PDF]
, 2010 The thymus constitutes the primary lymphoid organ responsible for the generation of naïve T cells. Its stromal compartment is composed of a scaffold of different subsets of epithelial cells that provide soluble and membrane-bound molecules essential for ...
Hauri-Hohl, Mathias Martin
core +1 more source
Investigating a Tbx1 and Pax9 genetic interaction during cardiovascular development [PDF]
, 2015 PHD ThesisCongenital cardiovascular malformations (CCVM) are the most common type of birth defect in humans and can be life threatening for the newborn. 22q11 deletion syndrome (22q11DS) is one of the most common CCVM in humans, with patients presenting ...
Briones Leon, Jose Alberto
core
Lysine Acetyltransferase 6 in Health and Disease
MedComm, Volume 6, Issue 12, December 2025.KAT6A and its paralog KAT6B have emerged as druggable targets for the treatment of malignancies, especially for breast cancer. Recent progress in drug discovery has promoted the development of dual inhibitors targeting KAT6A and KTA6B, which shows potent antitumor efficacy and manageable toxicity.
Yujing Tan, Jiani Wang, Fei Ma
wiley +1 more source
, 1998 peer reviewedPax genes have been shown to play important roles in mammalian development and organogenesis. Pax9, a member of this transcription factor family, is expressed in somites, pharyngeal pouches, mesenchyme involved in craniofacial, tooth, and ...
BALLING, Rudi +5 more
core +1 more source
Small Science, Volume 5, Issue 12, December 2025.The system employs a high density human dental stem cells‐laden oxidized alginate‐based microgel with a "degrade‐to‐active" paradigm that mimics cellular condensation to enhance cell viability, achieve robust vascularization, and promote subsequent dental organogenesis, which is enabled by rapid degradation along with the elimination of residual ...
Chao Liang +22 more
wiley +1 more source
Transcriptional analysis of the human PAX9 promoter [PDF]
, 2018 Orientador: Sergio Roberto Peres LineDissertação (mestrado) - Universidade Estadual de Campinas, Faculdade de Odontologia de PiracicabaResumo: O gene PAX9 pertence a uma família de fatores de transcrição denominada família Pax.
Almeida, Carolina Vieira de
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Experimental Dermatology, Volume 34, Issue 12, December 2025.ABSTRACT The epidermal differentiation complex (EDC) is a cluster of genes implicated in the control of the skin barrier. However, some EDC genes are also expressed at high levels in the human oesophagus. To determine whether the expression of EDC genes in the oesophagus is evolutionarily conserved, we performed comparative transcriptomic analyses of ...
Attila Placido Sachslehner +6 more
wiley +1 more source
Non-syndromic Oligodontia with a Novel Mutation of PAX9
, 2010 Agenesis of the permanent teeth is a congenital anomaly that is frequently seen in humans. Oligodontia is a severe type of tooth agenesis involving 6 or more congenitally missing teeth, excluding the third molars.
N. Suda +4 more
core +1 more source
E‐Cigarette and Vanillin Exposure Disrupts Cardiovascular Development in Xenopus laevis
Birth Defects Research, Volume 117, Issue 10, October 2025.ABSTRACT Introduction Congenital heart defects (CHDs) are a leading cause of perinatal mortality, and maternal cigarette smoking is a well‐established risk factor. In recent years, electronic cigarette (e‐cigarette) use has surged, yet its safety during pregnancy remains poorly defined.
James E. Black III +2 more
wiley +1 more source