Results 11 to 20 of about 1,625 (96)

Chromatin Remodeller BRD9 Orchestrates Odontoblastic Differentiation via Coordinating RUNX2-KLF4. [PDF]

Cell Prolif
During odontoblast lineage commitment, the chromatin remodeller BRD9 acts as a critical epigenetic coordinator, orchestrating the chromatin landscape to facilitate synergistic binding of key transcription factors RUNX2 and KLF4 to target loci for odontogenesis.
Zeng W, Lin Y, Gao Y, Huang D, Li Y, Ruan H, Yuan G, Liu H, Chen Z.   +8 more
europepmc   +2 more sources

A Combination of Variants in SEPTIN9 and MSX1 Genes Leads to the Formation of Orofacial Clefts. [PDF]

Genes Cells
Double‐depleted Xenopus embryos of xMSX1 and xSEPTIN9 exhibited orofacial clefts, and wild‐type but not variants in human MSX1 and human SEPTIN9 mRNAs could rescue the phenotype of morphants, indicating that variants in MSX1 and SEPTIN9, each individually tolerated, synergistically disrupt craniofacial morphogenesis to cause orofacial clefts.
Uuganbayar U, Manojlovic Z, Ito N, Yamaguchi R, Ninomiya H, Shimada IS, Yamada C, Feigelson D, Schulz G, Auslander A, Rakotoarison S, Magee W, Hashimoto Y, Kato Y.   +13 more
europepmc   +2 more sources

The Evolution of Gene Sequencing Technologies: Unveiling Genetic Architecture of Nonsyndromic Orofacial Clefts. [PDF]

Genet Res (Camb)
Nonsyndromic orofacial clefts (NSOC) are common congenital craniofacial developmental defects. Current evidence suggests that genetic factors, environmental exposures, and their interactions jointly contribute to the development of the disease. Owing to the high heritability of NSOC, identifying susceptibility genes and loci is a central focus of ...
Zhao H, Zhang S, Zhu H, Jia Z.
europepmc   +2 more sources

PAX9 polymorphism and susceptibility to sporadic non-syndromic severe anodontia: a case-control study in southwest China

Journal of Applied Oral Science, 2013
Our research aimed to look into the clinical traits and genetic mutations in sporadic non-syndromic anodontia and to gain insight into the role of mutations of PAX9, MSX1, AXIN2 and EDA in anodontia phenotypes, especially for the PAX9.
Jing WANG, Yuanzhi XU, Jing CHEN, Feiyu WANG, Renhuan HUANG, Songtao WU, Linjing SHU, Jingyi QIU, Zhi YANG, Junjie XUE, Raorao WANG, Jilin ZHAO, Wenli LAI   +12 more
doaj   +1 more source

The role of Msx1 and Pax9 in pathogenetic mechanisms of tooth agenesis

Dental Journal, 2009
Background: Tooth agenesis is one of the most common developmental anomalies in human, which one or a few teeth are absent because they have never formed, may cause cosmetic or occlusal harm, while severe agenesis which are relatively rare require ...
Yani Corvianindya Rahayu, dyah Setyorini
doaj   +1 more source

FOXN1: a master regulator gene of thymic epithelial development programme

Frontiers in Immunology, 2013
T cell ontogeny is a sophisticated process, which takes place within the thymus through a series of well-defined discrete stages. The process requires a proper lympho-stromal interaction.
Rosa eRomano, Loredana ePalamaro, Anna eFusco, Giuliana eGiardino, Vera eGallo, Luigi eDel Vecchio, Claudio ePignata   +6 more
doaj   +1 more source

Genetic factors define CPO and CLO subtypes of nonsyndromicorofacial cleft.

PLoS Genetics, 2019
Nonsyndromic orofacial cleft (NSOFC) is a severe birth defect that occurs early in embryonic development and includes the subtypes cleft palate only (CPO), cleft lip only (CLO) and cleft lip with cleft palate (CLP).
Lulin Huang, Zhonglin Jia, Yi Shi, Qin Du, Jiayu Shi, Ziyan Wang, Yandong Mou, Qingwei Wang, Bihe Zhang, Qing Wang, Shi Ma, He Lin, Shijun Duan, Bin Yin, Yansong Lin, Yiru Wang, Dan Jiang, Fang Hao, Lin Zhang, Haixin Wang, Suyuan Jiang, Huijuan Xu, Chengwei Yang, Chenghao Li, Jingtao Li, Bing Shi, Zhenglin Yang   +26 more
doaj   +1 more source

Ovarian Cancer: Epidemiology, Disease Mechanisms, New Diagnosis and Treatment Strategies, and Research Directions

iNew Medicine, EarlyView.
ABSTRACT Ovarian cancer (OC) continues to be the deadliest gynecological malignancy and a significant cause of cancer‐related mortality among women worldwide. Standard treatment strategies typically entail platinum‐based chemotherapy in conjunction with cytoreductive surgery.
Zunera Khalid, Weirong Fan, Farah Nazir, Yixiang Xing, Tengchuan Jin   +4 more
wiley   +1 more source

Reviewing the benefits and clinical outcomes of oral fibroblasts over mesenchymal stem cells for repairing periodontal defects during or after orthodontic tooth movement

Periodontology 2000, EarlyView.
Abstract Orthodontic therapy applies forces to teeth, causing an inflammatory reaction in the periodontal ligament. This is repaired by remodeling of the periodontium, allowing tooth displacement. Although orthodontic therapy is mostly initiated during childhood and adolescence, the number of adults seeking this treatment is increasing as our society's
Ludovica Parisi, Eleni Mavrogonatou, Anton Sculean, Dimitris Kletsas, Martin Degen   +4 more
wiley   +1 more source

From Association to Mechanism: Regulatory Annotation and Pathway Mapping of Genes Surrounding Breast Cancer Risk Variants

Computational and Systems Oncology, Volume 6, Issue 1, December 2026.
ABSTRACT Inherited factors account for a large share of breast cancer susceptibility, yet the biological consequences of most risk variants are still poorly understood. To address this gap, we studied 175 breast cancer risk variants confirmed by genome‐wide association studies and gathered the genes that lie near them.
Sultana Jannat, Trina Mitra, Nafisa Nawar Fariha, Tasmia Tabassum, Kulsuma Bahar Bethi, Synchita Majumder Kaya, Md. Arif Hossen, Md. Saad Hossain, Jobaier Ibne Deen, Mohammed Emon, Laila Khaleda, Md. Hridoy Ahmed   +11 more
wiley   +1 more source