Results 51 to 60 of about 1,648 (133)

Oncogenic cooperation and coamplification of developmental transcription factor genes in lung cancer

, 2007
We used high-resolution array analysis to discover a recurrent lung cancer amplicon located at 14q13.3. Low-level gain of this region was detected in 15% of lung cancer samples, and high-level amplification was detected in an additional 4% of samples ...
William L. Gerald, Kendall, J. T., Jude Kendall, Alex Krasnitz, Scott Powers, B. Lakshmi, David Mu, Powers, S., Nguyen, K. C. Q., Gerald, W., Lakshmi, B., Mu, D., Liu, Q. A., Amy Bakleh, Qing Liu, Krasnitz, A., Bakleh, A., Ken C. Q. Nguyen   +17 more
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PAX9 regulates squamous cell differentiation and carcinogenesis in the oro-esophageal epithelium [PDF]

PAX9 is a transcription factor of the PAX family characterized by a DNA-binding paired domain. Previous studies have suggested a potential role of PAX9 in squamous cell differentiation and carcinogenesis of the oro-esophageal epithelium.
Huang C, Peters H, Kist R, Chen H, Garman K, Sun Z, Xiong Z, Liu Y, Zhang YL, Chen X, Ren S, Odera JO, Chen T   +12 more
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Mutations in Exons 1 and 2 of PAX9 Gene and Hypodontia

, 2015
Hypodontia is one of the most common dental anomalies that result in aesthetic and functional problems. A wide range of prevalence values for missing teeth has been reported ranging from 1.6% to 25.4% in adult population. Our understanding of the genetic
Seto, Melanie, Hostage, Margaret, Kim, Eric, Hong, Soomin, Abolfazlian, Arash, Tolar, Miroslav, Deshmukh, Shweta, Tolarová, Marie M.   +7 more
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Genetic Approaches for the Diagnosis and Treatment of Congenital Tooth Agenesis [PDF]

, 2015
Congenital tooth agenesis is the most common developmental anomaly in man. More severe forms of tooth agenesis (> 5 missing teeth) demand lengthy and expensive treatment approaches such as bone augmentation surgeries and placement of multiple implants ...
Bonds, John Carless
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Critical microRNAs and Regulatory Motifs in Cleft Palate Identified by a Conserved miRNA-TF-Gene Network Approach in Humans and Mice

, 2020
Cleft palate (CP) is the second most common congenital birth defect. The etiology of CP is complicated, with involvement of various genetic and environmental factors.
Yoshioka, Hiroki, Suzuki, Akiko, Li, Aimin, Mallik, Saurav, Zhao, Zhongming, Jia, Peilin, Iwata, Junichi, Fei, Rong   +7 more
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Analyse des Promotors und der cis-regulatorischen Elemente, die die Expression des Pax9-Genes während der Embryonalentwicklung der Maus kontrollieren

, 2008
Pax9 codes for a transcription factor, which is expressed in various tissues during mouse development. By the determination of the exon/intron structure of the gene, a new 5'-exon and two alternative promoters were identified.
Santagati, Fabio
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FGF Signaling Is Necessary for the Specification of the Odontogenic Mesenchyme

, 2001
Tooth development is initiated by signals from the oral ectoderm which induce gene expression required for tooth development in the underlying mesenchyme.
Neubüser, Annette, Mandler, Markus
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Involvement of pax2 in ovarian development and recrudescence of catfish: a role in steroidogenesis

, 2016
PAX2, a member of paired box family, is an essential transcription factor for the organ development in vertebrates including teleosts, yet no evidence has been shown for its involvement in reproduction.
Prathibha, Yarikipati, Senthilkumaran, Balasubramanian   +1 more
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BMP signaling orchestrates a transcriptional network to control the fate of mesenchymal stem cells in mice

, 2017
Signaling pathways are used reiteratively in different developmental processes yet produce distinct cell fates through specific downstream transcription factors.
Jingyuan Li, Jian Xu, Tingwei Zhang, Hu Zhao, Junjun Jing, Yang Chai, Jifan Feng, Vasu Punj   +7 more
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PAX9 : uma ferramenta evolutiva?

, 2008
Um dos maiores objetivos na ciência atual é poder relacionar alterações nos genes a mudanças nas morfologias de organismos multicelulares. Além disso, é importante poder determinar se estas modificações foram obras do acaso ou se a seleção natural teve ...
Paixão Côrtes, Vanessa Rodrigues, Vanessa Rodrigues Paixão Côrtes   +1 more
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