Results 11 to 20 of about 3,069 (190)
Osr2 acts downstream of Pax9 and interacts with both Msx1 and Pax9 to pattern the tooth developmental field [PDF]
Developmental Biology, 2011 Mammalian tooth development depends on activation of odontogenic potential in the presumptive dental mesenchyme by the Msx1 and Pax9 transcription factors. We recently reported that the zinc finger transcription factor Osr2 was expressed in a lingual-to-buccal gradient pattern surrounding the developing mouse molar tooth germs and mice lacking Osr2 ...
Yu Lan, Rulang Jiang, Zhaoyang Liu
exaly +4 more sources
Msx1 haploinsufficiency modifies the Pax9-deficient cardiovascular phenotype [PDF]
BMC Developmental Biology, 2021 Abstract Background Successful embryogenesis relies on the coordinated interaction between genes and tissues. The transcription factors Pax9 and Msx1 genetically interact during mouse craniofacial morphogenesis, and mice deficient for either gene display abnormal tooth and palate development.
Khasawneh, Ramada +10 more
core +6 more sources
PAX9 (paired box gene 9) [PDF]
Atlas of Genetics and Cytogenetics in Oncology and Haematology, 2011 Review on PAX9 (paired box gene 9), with data on DNA, on the protein encoded, and where the gene is implicated.
E Robson, J Whall, M Eccles
openaire +3 more sources
The Evolution of Gene Sequencing Technologies: Unveiling Genetic Architecture of Nonsyndromic Orofacial Clefts. [PDF]
Genet Res (Camb)Nonsyndromic orofacial clefts (NSOC) are common congenital craniofacial developmental defects. Current evidence suggests that genetic factors, environmental exposures, and their interactions jointly contribute to the development of the disease. Owing to the high heritability of NSOC, identifying susceptibility genes and loci is a central focus of ...
Zhao H, Zhang S, Zhu H, Jia Z.
europepmc +2 more sources
Light-Inducible Activation of FGFR3 Facilitates Chondrocyte Maturation. [PDF]
Cell ProlifLight‐inducible activation of FGFR3 induced robust activation of MAPK signaling, promoting proliferation and collagen depositon in induced chondrocytes and prevent the degeneration of osteoarthritic chondrocytes.
Sun M +5 more
europepmc +2 more sources
Identification of a nonsense mutation in the PAX9 gene in molar oligodontia [PDF]
European Journal of Human Genetics, 2001 Development of dentition is controlled by numerous genes, as has been shown by experimental animal studies and mutations that have been identified by genetic studies in man. Here we report a nonsense mutation in the PAX9 gene that is associated with molar tooth agenesis in a Finnish family. The A340T transversion creates a stop codon at lysine 114, and
Satu Alaluusua +2 more
exaly +3 more sources
The Application of Clinical Genetics, 2018 Ahmed Abu-Siniyeh,1 Omar F Khabour,1 Arwa I Owais2 1Department of Medical Laboratory Sciences, Faculty of Applied Medical Sciences, Jordan University of Science and Technology, Irbid, Jordan; 2Department of Applied Dental Sciences, Faculty of Applied ...
Abu-Siniyeh A, Khabour OF, Owais AI
doaj +1 more source
Association between PAX9 or MSX1 gene polymorphism and tooth agenesis risk: A meta-analysis [PDF]
Open Life SciencesZhong Xiaoyi +4 more
doaj +2 more sources
Chitosan Hydrogel-Delivered ABE8e Corrects PAX9 Mutant in Dental Pulp Stem Cells
Gels, 2023 Hypodontia (dental agenesis) is a genetic disorder, and it has been identified that the mutation C175T in PAX9 could lead to hypodontia. Cas9 nickase (nCas9)-mediated homology-directed repair (HDR) and base editing were used for the correction of this ...
Bowen Liu +4 more
doaj +1 more source
Frontiers in Genetics, 2023 Background: Non-syndromic oligodontia is characterized by the absence of six or more permanent teeth, excluding third molars, and can have aesthetic, masticatory, and psychological consequences.
Jiabao Ren +12 more
doaj +1 more source