Results 11 to 20 of about 2,193 (172)
Transcriptional analysis of the human PAX9 promoter [PDF]
Journal of Applied Oral Science, 2010 OBJECTIVES: PAX9 belongs to the Pax family of transcriptional factor genes. This gene is expressed in embryonic tissues such as somites, pharyngeal pouch endoderm, distal limb buds and neural crest-derived mesenchyme.
Carolina Vieira de Almeida +4 more
doaj +5 more sources
Tooth agenesis patterns and variants in PAX9: A systematic review
Japanese Dental Science Review, 2023 Mutations in PAX9 are the most common genetic cause of tooth agenesis (TA). The aim of this study was to systematically review the profiles of the TA and PAX9 variants and establish their genotype-phenotype correlation.
Narin Intarak +4 more
doaj +3 more sources
Pax9 is essential for granulopoiesis but dispensable for erythropoiesis in zebrafish
Biochemical and Biophysical Research Communications, 2021 Paired Box (Pax) gene family, a group of transcription regulators have been implicated in diverse physiological processes. However, their role during hematopoiesis which generate a plethora of blood cells remains largely unknown. Using a previously reported single cell transcriptomics data, we analyzed the expression of individual Pax family members in
Boryeong Pak +12 more
openaire +2 more sources
Pax9’s Interaction With the Ectodysplasin Signaling Pathway During the Patterning of Dentition
Frontiers in Physiology, 2020 In these studies, we explored for the first time the molecular relationship between the paired-domain-containing transcription factor, Pax9, and the ectodysplasin (Eda) signaling pathway during mouse incisor formation.
Shihai Jia +9 more
doaj +1 more source
Characterization of PAX9 variant P20L identified in a Japanese family with tooth agenesis. [PDF]
PLoS ONE, 2017 Transcription factors PAX9 and MSX1 play crucial roles in the development of permanent teeth at the bud stage, and their loss-of-function variants have been associated with congenital tooth agenesis.
Akiko Murakami +5 more
doaj +1 more source
Tooth dimensions in hypodontia with a known PAX9 mutation [PDF]
Archives of Oral Biology, 2009 Congenital absence of teeth is a complex condition affecting several parameters of oral development. This is the first study to measure tooth crown dimensions using image analysis in a family with hypodontia in whom the mutation has been identified, and compare them with a control group.Study models were obtained from 10 family members from three ...
Brook, AH +6 more
openaire +2 more sources
PLoS Genetics, 2020 Dysregulation of ribosome production can lead to a number of developmental disorders called ribosomopathies. Despite the ubiquitous requirement for these cellular machines used in protein synthesis, ribosomopathies manifest in a tissue-specific manner ...
Katherine I Farley-Barnes +4 more
doaj +1 more source
Contrasting evolutionary dynamics of the developmental regulator PAX9, among bats, with evidence for a novel post-transcriptional regulatory mechanism. [PDF]
PLoS ONE, 2013 Morphological evolution can be the result of natural selection favoring modification of developmental signaling pathways. However, little is known about the genetic basis of such phenotypic diversity.
Caleb D Phillips +4 more
doaj +1 more source
Msx1 haploinsufficiency modifies the Pax9-deficient cardiovascular phenotype [PDF]
BMC Developmental Biology, 2021 Abstract Background Successful embryogenesis relies on the coordinated interaction between genes and tissues. The transcription factors Pax9 and Msx1 genetically interact during mouse craniofacial morphogenesis, and mice deficient for either gene display abnormal tooth and palate development.
Khasawneh, Ramada +10 more
openaire +4 more sources
Biology Open, 2017 Pax1 and Pax9 play redundant, synergistic functions in the patterning and differentiation of the sclerotomal cells that give rise to the vertebral bodies and intervertebral discs (IVD) of the axial skeleton. They are conserved in mice and humans, whereby
V. Sivakamasundari +6 more
doaj +1 more source