Results 61 to 70 of about 4,591 (213)

Reviewing the benefits and clinical outcomes of oral fibroblasts over mesenchymal stem cells for repairing periodontal defects during or after orthodontic tooth movement

Periodontology 2000, EarlyView.
Abstract Orthodontic therapy applies forces to teeth, causing an inflammatory reaction in the periodontal ligament. This is repaired by remodeling of the periodontium, allowing tooth displacement. Although orthodontic therapy is mostly initiated during childhood and adolescence, the number of adults seeking this treatment is increasing as our society's
Ludovica Parisi, Eleni Mavrogonatou, Anton Sculean, Dimitris Kletsas, Martin Degen   +4 more
wiley   +1 more source

Emulating the early phases of human tooth development in vitro [PDF]

, 2019
Functional in vitro models emulating the physiological processes of human organ formation are invaluable for future research and the development of regenerative therapies.
Amler, Anna-Klara, Bräunig, Julia, Lauster, Roland, Rosowski, Jennifer, Rosowski, Mark, Strietzel, Frank P.   +5 more
core   +1 more source

Deletion of a Pax1 Sex‐Associated Genomic Region Associated With Adolescent Idiopathic Scoliosis Leads to Disc Degeneration, Instability, and Vertebral Rotation in Mice

JOR SPINE, Volume 9, Issue 2, June 2026.
Overview of the effects of Pax1‐SAR deletion on gene expression, IVD degeneration, and resultant scoliotic‐like curvature between sexes. Proposed mechanism of sex‐dependent changes in gene expression in females (right) and males (left), resulting in sex‐dependent disc degeneration and scoliotic phenotypes.
Edward C. Moody, Emma M. Wade, Shuji Mizumoto, Jeremy McCallum‐Loudeac, Megan J. Wilson   +4 more
wiley   +1 more source

Pax9 is essential for granulopoiesis but dispensable for erythropoiesis in zebrafish

Biochemical and Biophysical Research Communications, 2021
Paired Box (Pax) gene family, a group of transcription regulators have been implicated in diverse physiological processes. However, their role during hematopoiesis which generate a plethora of blood cells remains largely unknown. Using a previously reported single cell transcriptomics data, we analyzed the expression of individual Pax family members in
Boryeong Pak, Chris E. Schmitt, Sera Oh, Jun-Dae Kim, Woosoung Choi, Orjin Han, Minjung Kim, Myoung-Jin Kim, Hyung-Jin Ham, Shanghyeon Kim, Tae-Lin Huh, Jae-Il Kim, Suk-Won Jin   +12 more
openaire   +2 more sources

Spatiotemporal expression of Pax genes in amphioxus: Insights into Pax-related organogenesis and evolution [PDF]

, 2010
The expression of four AmphiPax genes in 16 developmental stages and different organs in amphioxus (Branchiostoma belcheri) was investigated, finding those genes expressed throughout amphioxus life with temporal-specific (especially during embryogenesis ...
Chen Lu, Wang Wei, Wang YiQuan, Zhang QiuJing, 王义权   +4 more
core   +1 more source

The Homeobox Genes: Classification, Regulation, Biological Functions, and Diseases

MedComm, Volume 7, Issue 4, April 2026.
Overview of the homeobox gene superfamily and its pathophysiological roles. The homeobox superfamily comprises several major classes, including ANTP, PRD, TALE, LIM, POU, and others. Among these, the HOX clusters (A–D) play critical roles in embryonic development specifically in conferring cellular identity, regulating morphogenesis, and guiding axial ...
Maedeh Dadzadi, Shahin Ramazi, Mona Darvazi, Sepideh Yoosefi, Melika Abbasi, Shirin Farsad   +5 more
wiley   +1 more source

A novel mutation in the WNT6 gene of congenital tooth agenesis

口腔疾病防治, 2023
Objective This article explores the relationship between congenital tooth agenesis and related gene mutations, providing a reference for early diagnosis of the disease.
DAI Zhuo, LI Lili , ZHANG Xiaoxin , MOU Yongbin, CHEN Bin   +4 more
doaj   +1 more source

Molecular Evolution of the Primate Developmental Genes MSX1 and PAX9 [PDF]

Molecular Biology and Evolution, 2005
In primates, the craniofacial skeleton and the dentition are marked by high levels of interspecific variation. Despite this, there are few comparative species studies conducted at the molecular level to investigate this functional diversity. We have determined nucleotide sequences of MSX1 and PAX9, two developmental genes, in a sample of 27 diverse ...
George H, Perry, Brian C, Verrelli, Anne C, Stone   +2 more
openaire   +2 more sources

PAX9 Is Involved in Periodontal Ligament Stem Cell-like Differentiation of Human-Induced Pluripotent Stem Cells by Regulating Extracellular Matrix

Biomedicines, 2022
Periodontal ligament stem cells (PDLSCs) play central roles in periodontal ligament (PDL) tissue homeostasis, repair, and regeneration. Previously, we established a protocol to differentiate human-induced pluripotent stem cell-derived neural crest-like ...
Risa Sugiura, Sayuri Hamano, Atsushi Tomokiyo, Daigaku Hasegawa, Shinichiro Yoshida, Hideki Sugii, Shoko Fujino, Orie Adachi, Masataka Kadowaki, Daiki Yamashita, Hidefumi Maeda   +10 more
doaj   +1 more source

Delayed Dental Development in Children With Non‐Syndromic Hypodontia: A Cross‐Sectional Study Using a Machine Learning Approach to Dental Age Estimation

Orthodontics &Craniofacial Research, Volume 29, Issue 2, Page 347-356, April 2026.
ABSTRACT Objectives To investigate the influence of non‐syndromic hypodontia on radiographic dental development and to estimate dental age in children with bilateral mandibular agenesis using a machine learning approach. Materials and Methods This retrospective cross‐sectional study included 626 children aged 6–15 years (311 with dental agenesis, 315 ...
Marine Crosnier, Pierre‐Hadrien Decaup, Frédéric Santos, Anaïs Cavare   +3 more
wiley   +1 more source