Results 81 to 90 of about 4,591 (213)

Lysine Acetyltransferase 6 in Health and Disease

MedComm, Volume 6, Issue 12, December 2025.
KAT6A and its paralog KAT6B have emerged as druggable targets for the treatment of malignancies, especially for breast cancer. Recent progress in drug discovery has promoted the development of dual inhibitors targeting KAT6A and KTA6B, which shows potent antitumor efficacy and manageable toxicity.
Yujing Tan, Jiani Wang, Fei Ma
wiley   +1 more source

Genotyping analysis of the Pax9 Gene in patients with maxillary canine impaction [version 1; peer review: 2 approved]

F1000Research, 2019
Background: Paired-box gene 9 (PAX9) mutation is potentially associated with impaction in some patient populations. Here, we analyzed the relationship between PAX9 polymorphism and the occurrence of maxillary canine impaction.
Evy Eida Vitria, Iwan Tofani, Lindawati Kusdhany, Endang Winiati Bachtiar   +3 more
doaj   +1 more source

Retinoic acid signaling acts via Hox1 to establish the posterior limit of the pharynx in the chordate amphioxus [PDF]

, 2004
In the invertebrate chordate amphioxus, as in vertebrates, retinoic acid (RA) specifies position along the anterior/posterior axis with elevated RA signaling in the middle third of the endoderm setting the posterior limit of the pharynx.
Escriva, Hector, Holland, Linda Z., Holland, Nicholas D., Laudet, Vincent, Schubert, Michael, Yu, Jr-Kai   +5 more
core   +2 more sources

Harnessing Oxidized Alginate Microgels for Rapid and Self‐Assembling Dental Tissue Organogenesis In Vitro and In Vivo

Small Science, Volume 5, Issue 12, December 2025.
The system employs a high density human dental stem cells‐laden oxidized alginate‐based microgel with a "degrade‐to‐active" paradigm that mimics cellular condensation to enhance cell viability, achieve robust vascularization, and promote subsequent dental organogenesis, which is enabled by rapid degradation along with the elimination of residual ...
Chao Liang, Shuxuan Wu, Ziqi Huang, Zhenzhen Wu, Siyuan Chen, Feiming Li, Karrie Mei‐Yee Kiang, Gilberto Ka‐Kit Leung, Indong Jun, Hwan D. Kim, Ann‐Na Cho, Hee Jung Lee, Honghyun Park, Yiu Yan Leung, Seong Jun Kim, Seil Sohn, Haram Nah, Jae Seo Lee, Il Keun Kwon, Dong‐Nyoung Heo, Sang‐woo Lee, Zhaoming Wu, Sang Jin Lee   +22 more
wiley   +1 more source

Expression of interferon regulatory factor 6, muscle segment homeobox 1, paired box gene 9, homeo box B3, and related to tyrosine kinases in human cleft-affected tissue

Journal of Orofacial Sciences, 2016
Background and Aim: Recent studies demonstrate direct roles of different genes during formation of secondary palate, but there are no still data about local expression and distribution of gene products in cleft palate affected human tissue. Thus, the aim
Benita Krivicka-Uzkurele, Mara Pilmane
doaj   +1 more source

Research progress on pathogenic genes and molecular mechanisms of nonsyndromic tooth agenesis

口腔疾病防治, 2020
Tooth agenesis is a common tooth number deficiency that occurs in the tooth-forming process or earlier period of tooth germ development and has a serious impact on the maxillofacial development, aesthetics and masticatory function of patients.
XIE Weihong, YU Dongsheng, ZHAO Wei
doaj   +1 more source

Analyses of oligodontia phenotypes and genetic etiologies

International Journal of Oral Science, 2021
Oligodontia is the congenital absence of six or more teeth and comprises the more severe forms of tooth agenesis. Many genes have been implicated in the etiology of tooth agenesis, which is highly variable in its clinical presentation.
Mengqi Zhou, Hong Zhang, Heather Camhi, Figen Seymen, Mine Koruyucu, Yelda Kasimoglu, Jung-Wook Kim, Hera Kim-Berman, Ninna M. R. Yuson, Paul J. Benke, Yiqun Wu, Feng Wang, Yaqin Zhu, James P. Simmer, Jan C-C. Hu   +14 more
doaj   +1 more source

Evaluación de riesgo sobre la salud humana frente a la exposicion ocupacional a químicos de uso agrario en el Soberbio, Misiones. 16H332 [PDF]

, 2011
Se trata de las actividades efectivamente realizadas durante el período de referencia. Pueden ser las mismas que las incluidas en el Proyecto, pero también pueden aparecer nuevas actividades que no hayan sido previstas originalmente: Puesta a punto de ...
Achon, Marisol, Bravin, Carolina, Fernandez de la Puente, Graciela, Galeano Velazquez, Zulema, González, Carlos Oscar, codir., Marín, Cristina, dir., Padula, Diego, Quiroga, Ana María, Schneider, Sonia Alejandra, Schwieter, Horacio   +9 more
core  

Molecular profiling of the developing mouse axial skeleton: a role for Tgfbr2 in the development of the intervertebral disc [PDF]

, 2010
Background Very little is known about how intervertebral disc (IVD) is formed or maintained. Members of the TGF-β superfamily are secreted signaling proteins that regulate many aspects of development including cellular differentiation. We recently showed
Philip Sohn, Megan Cox, Dongquan Chen, Rosa Serra   +3 more
core   +2 more sources

Comparative Transcriptomics Reveals a Dual Role of the Epidermal Differentiation Complex in the Skin and the Oesophagus

Experimental Dermatology, Volume 34, Issue 12, December 2025.
ABSTRACT The epidermal differentiation complex (EDC) is a cluster of genes implicated in the control of the skin barrier. However, some EDC genes are also expressed at high levels in the human oesophagus. To determine whether the expression of EDC genes in the oesophagus is evolutionarily conserved, we performed comparative transcriptomic analyses of ...
Attila Placido Sachslehner, Julia Lachner, Veronika Mlitz, Bahar Golabi, Claudia Hess, Wolfgang Sipos, Leopold Eckhart   +6 more
wiley   +1 more source