Results 101 to 110 of about 4,591 (213)

Deconstructing the Thymic Microenvironment Through Genesis to Senescence

Immunological Reviews, Volume 332, Issue 1, July 2025.
ABSTRACT The thymus is essential for adaptive immunity, orchestrating the differentiation of hematopoietic progenitors into various T‐cell lineages. Thymic epithelial cells (TECs) impart this unique function by mediating the major checkpoints in T‐cell differentiation while also imposing stringent tolerance processes required to prevent autoimmunity ...
Michael D'Andrea, Kelin Zhao, Daniel H. D. Gray   +2 more
wiley   +1 more source

Functional Analyses of SATB2 Variants Reveal Pathogenicity Mechanisms Linked With SATB2‐Associated Syndrome

American Journal of Medical Genetics Part A, Volume 197, Issue 6, June 2025.
ABSTRACT SATB2‐associated syndrome (SAS) is characterized by intellectual disability, neurodevelopmental disorders, cleft palate, and dental abnormalities. SAS is caused by variants in the special AT‐rich sequence‐binding protein 2 (SATB2), which encodes a transcription factor containing two CUT domains and a homeobox (HOX) domain.
Nao Ukita, Takuya Ogawa, Mamiko Yamada, Chisen Takeuchi, Kenjiro Kosaki, Keiji Moriyama   +5 more
wiley   +1 more source

Expression of Odontogenic Genes in Human Bone Marrow Mesenchymal Stem Cells [PDF]

Cell Journal, 2013
Objective: Tooth loss is a common problem and since current tooth replacement methods cannot counter balance with biological tooth structures, regenerating natural tooth structures has become an ideal goal.
Seyedeh Sara Bagheri, Nazanin Mahdavi, Hamed Sichani Fallahi, Ahad Khoshzaban, Fatemeh Mashhadi Abbas   +4 more
doaj  

The role of PAX9 promoter gene polymorphisms in causing hypodontia: a study in the Jordanian population

The Application of Clinical Genetics, 2018
Ahmed Abu-Siniyeh,1 Omar F Khabour,1 Arwa I Owais2 1Department of Medical Laboratory Sciences, Faculty of Applied Medical Sciences, Jordan University of Science and Technology, Irbid, Jordan; 2Department of Applied Dental Sciences, Faculty of Applied ...
Abu-Siniyeh A, Khabour OF, Owais AI
doaj  

Associations of common breast cancer susceptibility alleles with risk of breast cancer subtypes in BRCA1 and BRCA2 mutation carriers [PDF]

, 2014
Peer reviewedPublisher ...
Andrulis, Irene L, Arun, Banu K, Barrowdale, Daniel, Benitez, Javier, Breast Cancer Family Registry, Buys, Saundra S, Cass, Ilana, Cunningham, Julie, Daly, Mary B, Dennis, Joe, Domchek, Susan M, Dorfling, Cecilia M, Duran, Mercedes, Ejlertsen, Bent, Engel, Christoph, Gerdes, Anne-Marie, Goldgar, David E, Hart, Steven, Healey, Sue, James, Paul, Janavicius, Ramunas, Karlan, Beth Y, Kuchenbaecker, Karoline B, Lee, Andrew, Lester, Jenny, McGuffog, Lesley, Miedzybrodzka, Zofia Helena, Mulligan, Anna Marie, Nathanson, Katherine L, Neuhausen, Susan L, Nevanlinna, Heli, Nielsen, Finn C, Nussbaum, Robert L, Osorio, Ana, Radice, Paolo, Ramus, Susan J, Rebbeck, Timothy R, Robson, Mark, Schmidt, Marjanka K, Schmutzler, Rita K, Slager, Susan, Southey, Melissa, Spurdle, Amanda B, Steele, Linda, Terry, Mary Beth, Thomassen, Mads, Tihomirova, Laima, Tung, Nadine, v O Hansen, Thomas, van Rensburg, Elizabeth J, Wappenschmidt, Barbara   +50 more
core   +3 more sources

Dental agenesis: review of the literature and report of two cases

Revista Facultad de Odontología Universidad de Antioquia, 2006
Tooth agenesis is the most common anomaly of craniofacial development. The purpose of this report is to present a brief review of literature about tooth agenesis, which includes: terminology, etiology, prevalence, associated syndromes and dental ...
Luz Ángela Arboleda-A. , Jacqueline Echeverri-E. , Luz Ángela Restrepo-P. , Martha Lucía Marín-B. , Gonzalo Vásquez-P. , July Catalina Gómez-M., Hugo Alexánder Manco-G. , Clara María Pérez-S. , Elizabeth Taborda-F.   +8 more
doaj  

The role of Msx1 and Pax9 in pathogenetic mechanisms of tooth agenesis

Dental Journal, 2009
Background: Tooth agenesis is one of the most common developmental anomalies in human, which one or a few teeth are absent because they have never formed, may cause cosmetic or occlusal harm, while severe agenesis which are relatively rare require ...
Yani Corvianindya Rahayu, dyah Setyorini
doaj   +1 more source

A novel 14q13.1–21.1 deletion identified by CNV-Seq in a patient with brain-lung-thyroid syndrome, tooth agenesis and immunodeficiency

Molecular Cytogenetics, 2019
Background Chromosome 14q11-q22 deletion syndrome (OMIM 613457) is a rare genomic disorder. The phenotype heterogeneity depends on the deletion size, breakpoints and genes deleted. Critical genes like FOXG1, NKX2–1, PAX9 were identified.
Xuyun Hu, Jun Liu, Ruolan Guo, Jun Guo, Zhipeng Zhao, Wei Li, Baoping Xu, Chanjuan Hao   +7 more
doaj   +1 more source

The presence and distribution of various genes in postnatal CLP-affected palatine tissue

Maxillofacial Plastic and Reconstructive Surgery
Background Worldwide cleft lip with or without a cleft palate (CL/P) is the most common craniofacial birth defect. Apart from changes in facial appearance, additionally affected individuals often suffer from various associated comorbidities requiring ...
Jana Goida, Mara Pilmane
doaj   +1 more source

Mechanisms and molecular regulation of mammalian tooth replacement [PDF]

, 2008
In most non-mammalian vertebrates, such as fish and reptiles, teeth are replaced continuously. However, tooth replacement in most mammals, including human, takes place only once and further renewal is apparently inhibited.
Järvinen, Elina
core